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EU and Regulatory Autonomy on the Digital Trade Frontier

Amid the rapid expansion of the global digital economy, the European Union faces a fundamental tension between promoting digital trade liberalisation and safeguarding its regulatory autonomy. This thesis examines how policy space provisions within the EU's new, standalone Digital Trade Agreements (DTAs) with Singapore and South Korea relate to this strategic challenge. Using a legal doctri-nal

Whose risk counts? Climate risk frames in global green finance governance complex

In recent decades, global green finance governance institutions (GGFGIs) have developed diverse frames for understanding climate-related risks. Understanding these risk frames is crucial because they lead to distinctive “de-risking” policies, empowering different types of actors. This paper examines how GGFGIs produce different climate risk frames, and what the prevailing climate risk frame is and

Facilitators influencing participation in digitally-based high-intensity interval training among individuals with axial spondyloarthritis - a qualitative study

Background: Physical exercise is part of the recommended treatment for individuals with axial spondyloarthritis (axSpA). High-intensity interval training (HIIT) is an effective way to improve cardiovascular health without risk of increased disease activity. Nevertheless, there is a lack of knowledge regarding facilitating factors for digitally-based HIIT among individuals with axSpA. Objective: Th

Presentation of gastrointestinal bleeding in patients with antithrombotic therapy, results from a consecutive retrospective cohort

Background: Antithrombotic treatment might affect bleeding symptoms, identification of bleeding source and treatment for patients with acute gastrointestinal bleeding. This study aims to investigate possible differences in initial bleeding symptoms, identified bleeding site and treatment of patients with or without antithrombotic medication admitted for gastrointestinal bleeding. Methods: All cons

Polygenic scores in Familial breast cancer cases with and without pathogenic variants and the risk of contralateral breast cancer

Background: Polygenic risk scores (PRS) are not yet standard in clinical risk assessments for familial breast cancer in Sweden. This study evaluated the distribution and impact of an established PRS (PRS313) in women undergoing clinical sequencing for hereditary breast cancer. Findings: We integrated PRS313 into a hereditary breast cancer gene panel used in clinical practice and calculated scores

Comparisons of health-related factors in children with attention-deficit/hyperactivity disorder with and without sleep problems following a weighted blanket sleep intervention

Background: Adequate sleep is crucial for children’s health, especially for children with ADHD and concurrent sleep problems. There is a need for more studies focusing on sleep problems in children with ADHD as these problems may exacerbate ADHD symptoms and vice versa, impacting negatively on everyday life. The aim of this study was to investigate the differences in health-related factors between

Psychological health among livestock owners, the potential effect of large carnivores

Sustainable wildlife management should, amongst others, safeguard human health. This study concerns rural residents’ perceived quality of life and the potential effect of large carnivores (LCs) on psychological health outcomes (life satisfaction, anxiety symptoms, and exhaustion). One group of rural residents that appears to be especially vulnerable when the number and range of LCs increase is she

Prenatal exposure to a mixture of per- and polyfluoroalkyl substances (PFAS) and lung function and immune-related outcomes among males in childhood and young adulthood

Background: Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) may influence lung and immune system development, but previous epidemiological studies are inconclusive and have not extended into young adulthood. Objective: To examine associations between prenatal exposure to a mixture of PFAS and respiratory and immune-related outcomes in a cohort of males. Methods: We studied 866 male

Identification of Neuritin 1 as a local metabolic regulator of brown adipose tissue

Brown adipose tissue (BAT) plays a key role in metabolic homeostasis through its thermogenic effects and the secretion of regulatory molecules. Here we report that RAP250 haploinsufficiency stimulates BAT in mice, thus contributing to a decrease in fat accumulation. Local in vivo AAV-mediated RAP250 silencing in BAT reduces body weight and fat mass and enhances glucose oxidation, thereby indicatin

High resolution Ordovician (Floian-Sandbian) carbon isotope stratigraphy from the Jiangnan slope, South China : The first complete record of the MDICE in δ13Corg and its global significance

The Middle Darriwilian Isotopic Carbon Excursion (MDICE) is one of the globally recognized positive excursions in carbon isotope chemostratigraphy, but mainly documented by δ13Ccarb data in previous research. In this paper, new stable organic carbon isotope data (δ13Corg) are presented from the Hule-1 core from the southern Anhui Province of southern China. The core constitutes an Ordovician silic

The metabolic signature of salt intake : a cross-sectional analysis from the SCAPIS-study

Background: Untargeted metabolomic analysis provides novel insights into the relationship between sodium intake and cardiometabolic risk. This study examined cross-sectional associations between estimated sodium intake and plasma metabolite profiles in a large Swedish cohort. Methods: This cross-sectional analysis was conducted in the in the SCAPIS cohort (mean age 50–64 years, n = 8,957). Sodium

A data-driven early warning system for Escherichia coli in water based on microbial community analysis using flow cytometry 2D histograms

Traditional methods for microbial water quality testing take up to two days to produce results, putting humans in contact with this water risk during this period. Flow cytometry, including with online capacity, is a fast and efficient way to profile microbes in water. In this study, Escherichia coli concentrations determined by Colilert18 and flow cytometry profiles from the same water samples wer

Whole genome transcriptional analysis of intestinal biopsies and blood cells indicate genes involved in antioxidant defense systems, amino acid metabolism and antigen presentation in the pathogenesis of celiac disease

Background: Celiac disease is associated with HLA-risk haplotypes, but non-HLA genes and environmental factors are also linked to disease susceptibility. In this study, we explore the molecular pathways involved in celiac disease by analyzing the differential expression of genes in both the gut and peripheral blood across various celiac disease phenotypes. Methods: Whole genome RNA sequencing was