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Spin and electronic structure of the topological insulator Bi1.5Sb0.5Te1.8Se1.2

Electronic and spin structure of the Dirac-cone-like topological surface and valence band states were studied experimentally and theoretically for topological insulator with fractional stoichiometry Bi1.5Sb0.5Te1.8Se1.2 which is considered as one of the best candidates for efficient spin-polarized current generation. By means of spin- and angle-resolved photoelectron spectroscopy we demonstrate th

Scots pine (Pinus sylvestris L.) based reconstruction of 130 years of water table fluctuations in a peatland and its relevance for moisture variability assessments

Continuous water-table (WT) measurements from peatlands are scarce and – if existing at all –very short. Consequently, proxy indicators are critically needed to simulate hydrological changes in peatlands over longer time periods. In this study, we demonstrate that tree-ring width (TRW) records of Scots pine (Pinus sylvestris L.) growing in the Čepkeliai peatland (southern Lithuania) can be used as

Amyloid pathology in the progression to mild cognitive impairment

The objective of this study was to determine the cognitive and functional decline and development of brain injury in individuals progressing from preclinical (β-amyloid positive cognitively normal) to prodromal Alzheimer's disease (AD) (β-amyloid positive mild cognitive impairment [MCI]), and compare this with individuals who progress to MCI in the absence of significant amyloid pathology. Seventy

Ovarian cancer early detection by circulating CA125 in the context of anti-CA125 autoantibody levels : Results from the EPIC cohort

CA125 is the best ovarian cancer early detection marker to date; however, sensitivity is limited and complementary markers are required to improve discrimination between ovarian cancer cases and non-cases. Anti-CA125 autoantibodies are observed in circulation. Our objective was to evaluate whether these antibodies (1) can serve as early detection markers, providing evidence of an immune response t

Cardiovascular disease in systemic lupus erythematosus is associated with increased levels of biomarkers reflecting receptor-activated apoptosis

Background and aims: There is convincing evidence that adaptive immune responses affect the development of atherosclerosis and thrombosis and several autoimmune diseases are associated with increased cardiovascular risk. However, our understanding of the underlying mechanisms remains limited. We investigated how biomarkers reflecting four aspects of autoimmunity: apoptosis, inflammation, tissue de

Increased hope following successful treatment for hepatitis C infection

Aims: To evaluate hope in hepatitis C patients 9 years after curative treatment with pegylated interferon and ribavirin. Background: Successful treatment of hepatitis C leads to improved quality of life in responders compared with non-responders. The long-term effect of successful treatment on hope in these patients is not known. Design: Cross-sectional follow-up study of patients who displayed a

Aberrant neural crest development causes craniofacial and other malformations in an animal model of Musculocontractural Ehlers-Danlos syndrome.

Musculocontractural Ehlers-Danlos syndrome (MC-EDS) is a rare recessive disorder that is characterized by connective tissue fragility, distinct craniofacial features and congenital malformations. MC-EDS patients have defects in the enzymes dermatan sulfate epimerase-1 and dermatan 4-O-sulfotransferase-1, which are involved in the biosynthesis of iduronic acid in the chondroitin sulfate/dermatan su

Synthesis of fluorescent molecularly imprinted nanoparticles for turn-on fluorescence assay using one-pot synthetic method and a preliminary microfluidic approach

Fluorescent molecularly imprinted polymers (MIPs) have received considerable attention for their promising applications in sensing, imaging and diagnostics. Different synthetic methods have been reported to prepare fluorescent MIPs. Here, one-pot polymerization method was developed to synthesize fluorescent MIP nanoparticles (NPs) bearing a suitable fluorescent label as the fluorescence acceptor.

Psychosocial behaviour management programme for home-dwelling people with dementia : A cluster-randomized controlled trial

Little is known about the effectiveness of a psychosocial behaviour management programme on home-dwelling people with dementia. We developed a Behaviour Analytics & Support Enhancement (BASE) programme for care managers and professional caregivers of home care services in Japan. We investigated the effects of BASE on challenging behaviour of home-dwelling people with dementia. Methods: A clust

Experimentally increased nest temperature affects body temperature, growth and apparent survival in blue tit nestlings

The thermal environment experienced by birds during early postembryonic development may be an important factor shaping growth and survival. However, few studies have directly manipulated nest temperature (T n) during the nestling phase, and none have measured the consequences of experimental heat stress on nestlings’ body temperature (T b). It is therefore not known to what extent any fitness consThe thermal environment experienced by birds during early postembryonic development may be an important factor shaping growth and survival. However, few studies have directly manipulated nest temperature (T n) during the nestling phase, and none have measured the consequences of experimental heat stress on nestlings’ body temperature (T b). It is therefore not known to what extent any fitness cons

Pilot Study of Cardiotocography

A major problem in CTG analysis is that detectionof a suspicious pattern in short intervals so that one can reducethe damage caused by a delay of an automatic monitoringsystem. In this paper, we aim for improving intrapartumsurveillance based on signal processing and machine learningtechniques. We evaluate a classification method on a real dataset.

LRN 2016 SPECIAL – high capacity vehicles and modal shift from rail to road : combining macro and micro analyses

This paper addresses a road transport policy of allowing high capacity vehicles (HCVs) on the roads. The purpose is to examine the effect reduced road transport costs from HCVs can have on a modal shift. Two studies of HCV implementation in Sweden were combined. A micro-based case study modelled the distribution network of a major retailer in scenarios based on actual cost and flow data. A macro a

Strong spin-orbit interaction and magnetotransport in semiconductor Bi2O2Se nanoplates

Semiconductor Bi2O2Se nanolayers of high crystal quality have been realized via epitaxial growth. These two-dimensional (2D) materials possess excellent electron transport properties with potential application in nanoelectronics. It is also strongly expected that the 2D Bi2O2Se nanolayers can be an excellent material platform for developing spintronic and topological quantum devices if the presenc

A theoretical and experimental benchmark study of core-excited states in nitrogen

The high resolution near edge X-ray absorption fine structure spectrum of nitrogen displays the vibrational structure of the core-excited states. This makes nitrogen well suited for assessing the accuracy of different electronic structure methods for core excitations. We report high resolution experimental measurements performed at the SOLEIL synchrotron facility. These are compared with theoretic

Pain sensitivity and pericranial tenderness in children with tension-type headache: A controlled study

Purpose: To compare tenderness and pain sensitivity in children (aged 7–17 years) with tension-type headache (TTH) and healthy controls using total tenderness score (TTS), pressure pain threshold (PPT), and pain perceived at suprapressure pain threshold (supraPPT). Patients and methods: Twenty-three children with frequent episodic TTH, 36 with chronic TTH, and 57 healthy controls were included. TT

Genetic predisposition to infection in a case of atypical hemolytic uremic syndrome

Most cases of hemolytic uremic syndrome (HUS) are caused by infection with enterohemorrhagic Escherichia coli (EHEC). Genetic defects causing uncontrolled complement activation are associated with the more severe atypical HUS (aHUS). Non-EHEC infections can trigger the disease, however, complement defects predisposing to such infections have not yet been studied. We describe a 2-month-old patient

Complement C4d-specific antibodies for the diagnosis of lung cancer

Development of molecular markers that help to identify high-risk individuals or diagnose indeterminate pulmonary nodules could have a major impact on lung cancer clinical management. In this study, we evaluated the diagnostic potential of a newly-developed ELISA that specifically detects complement C4d. We measured this marker in five independent cohorts of plasma and bronchoalveolar lavage sample

Higher burden of supraventricular ectopic complexes early after catheter ablation for atrial fibrillation is associated with increased risk of recurrent atrial fibrillation

Early identification of patients who could benefit from early re-intervention after catheter ablation is highly warranted. Our aim was to investigate the association between post-procedural burden of supraventricular ectopic complexes (SVEC) and the risk of long-term atrial fibrillation (AF) recurrence. A total of 125 patients undergoing catheter ablation for AF were included. Patients underwent 7