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Differential Glucose-Regulation of MicroRNAs in Pancreatic Islets of Non-Obese Type 2 Diabetes Model Goto-Kakizaki Rat.

The Goto-Kakizaki (GK) rat is a well-studied non-obese spontaneous type 2 diabetes (T2D) animal model characterized by impaired glucose-stimulated insulin secretion (GSIS) in the pancreatic beta cells. MicroRNAs (miRNAs) are short regulatory RNAs involved in many fundamental biological processes. We aim to identify miRNAs that are differentially-expressed in the pancreatic islets of the GK rats an

Some results concerning design and decoding of turbo-codes

We consider the following problems related to the construction and analysis of turbo-codes: asymptotic behavior of interleavers (permutors), asymptotic behavior of the minimum distance, and also some examples of practical application of the developed methods to concrete turbo-codes.

Automation and the nature of driving - The effect of adaptive cruise control on drivers' tactical driving decisions

Advanced driving assistance systems that offer support by operating for example longitudinal control will have an effect on the transport system. Previous studies have also shown that drivers may be slower to respond in hazardous situations with systems like adaptive cruise control (ACC) engaged, if the system suddenly fails. Little understanding has, so far, emerged to explain why. In this thesis

Epidermal growth factor receptor and vascular endothelial growth factor receptor 2 are specific biomarkers in triple-negative breast cancer. Results from a controlled randomized trial with long-term follow-up.

Triple-negative breast cancer (TNB) has poor prognosis and moreover patients with TNB do not benefit from established targeted drugs with endocrine therapy or trastuzumab. The aim of the study was to analyze the prevalence of candidate biomarkers in tumors from patients with TNB. Tissue microarrays were prepared from primary tumors from premenopausal breast cancer patients (500/564) randomized to

Challenges of immediate newborn care in maternity units in Lagos, Nigeria: An observational study.

Substandard newborn care has been identified as a major contributor to the estimated annual 4 million neonatal deaths and 1 million fresh stillbirths. Low-income countries, including Nigeria account for more than 95% of all cases. A cross-sectional comparative study utilising non-participant observation methods was used to study perinatal care at two maternity centres in Lagos, Nigeria. Data on 63

Role of ERK/MAPK in endothelin receptor signaling in human aortic smooth muscle cells.

ABSTRACT: muscle cells (VSMCs) through activation of endothelin type A (ETA) and type B (ETB) receptors. The extracellular signal-regulated kinase 1 and 2 (ERK1/2) mitogen-activated protein kinases (MAPK) are involved in ET-1-induced VSMC contraction and proliferation. This study was designed to investigate the ETA and ETB receptor intracellular signaling in human VSMCs and used phosphorylation (a

Från skärva till kärl : ett bidrag till vardagslivets historia i Uppsala.

Popular Abstract in Swedish Från skärva till kärl fokuserar på ett arkeologiskt massmaterial, en materialkategori som är särskilt vanlig framför andra bland de arkeologiska fynden. Skärvor är fragment av keramiska kärl och analysen kommer att färdas från det lilla till det något större - från skärva till kärl. I centrum återfinns de kärl som varit i bruk i Uppsala från 1100-talets mitt till 1700-tAbstract From Sherd to Pot. A Contribution to the History of Everyday Life in Uppsala tackles the question: how is the culturally created reality produced, fixed, and changed, and how can this be related to the social structure as a whole? The hypothesis is that changes in society result in new cultural patterns which can be read in objects. The work consists of three main parts, an extensive summ

Uromodulin gene variant is associated with type 2 diabetic nephropathy.

AIMS/HYPOTHESIS: About 35% of individuals with type 2 diabetes develop persistent albuminuria, lose renal function, and are at increased risk for microvascular complications like diabetic nephropathy. Recent genome-wide association studies have identified the uromodulin locus (UMOD), encoding the most common protein in human urine to be associated with hypertension and also with chronic kidney dis