Background: There is an urgent need for effective treatments against glioblastoma (GBM). In this trial, we investigated the efficacy and safety of an adoptive cell-based immunotherapy. Methods: Patients with newly diagnosed GBM were recruited at 4 study sites in Sweden. The patients were randomized 1:2 to receive either radiotherapy (RT), 60 Gy/30 fractions, with concomitant and adjuvant temozolom

Background: Targeted therapeutic mild hypercapnia may attenuate brain injury in comatose adults resuscitated from out-of-hospital cardiac arrest. Objective: To describe the study protocol and statistical analysis plan for the Targeted Therapeutic Mild Hypercapnia after Resuscitated Cardiac Arrest (TAME) trial. Design, setting, participants and interventions: TAME is a phase 3, multicentre, paralle

Based on the critical velocity model, impact and capture efficiencies in an AGTB turbine cascade are investigated numerically under various inlet angles of mainstream, blowing ratios, particle sizes, and particle densities. The effect of hole configuration on deposition is analyzed based on comparisons of results from combined hole and cylindrical hole. The impact efficiency increases with the inc

This paper presents a detailed sedimentologic data set of minor moraines (heights ≤2.0 m, widths ≤14 m, lengths ≤108 m) that formed beginning near the end of the Little Ice Age by Schwarzensteinkees, a valley glacier in Austria. Sorted sediment and stratified diamict dominate five exposures, and compact massive diamict exists in one exposure. This sediment is interpreted as proglacial outwash and

Gender, being an identity contingency as coined by Claude M. Steele in his book Whistling Vivaldi, is not self-chosen, is virtually impossible to escape, and comes with expectations, prejudice and – most importantly – uneven pre-conditions for our choices in life. Gender inequality is a wide-spread problem, causing much harm on theindividual and societal levels, and the academic world is no exempt

It is commonly accepted that exoplanets with orbital periods shorter than one day, also known as ultra-short-period (USP) planets, formed further out within their natal protoplanetary disks before migrating to their current-day orbits via dynamical interactions. One of the most accepted theories suggests a violent scenario involving high-eccentricity migration followed by tidal circularization. He

En betydande del av Europas byggnadsbestånd behöver renoveras. De vanligaste anledningarna till att man genomför renoveringar är akuta tekniska problem eller en byggnads eller dess komponenters utgående livslängd. Andra vanliga skäl för byggherrar att genomföra renoveringar i sitt byggnadsbestånd är höga kostnader för underhåll och drift samt ett högt energibehov. Dessutom har bygg- och fastighetsA considerable amount of Europe’s building stock needs to be renovated. The most common reasons for carrying out renovations are acute technical issues or the expiring life span of a building or its components. Other common reason for building owners to carry out renovations in their building stock are high costs for maintenance and operation, and a high energy demand. Furthermore, the constructio

Introduction: This retrospective study investigated a cortical microvascular formation, termed a ‘raspberry’ due to its appearance under a bright-field microscope. We examined whether there is support for the hypothesis that raspberry formation is an angiogenic process induced by cerebral hypoperfusion. Materials and Methods: Raspberries were manually quantified in haematoxylin and eosin-stained c

Background: Rectal cancer treatment has improved through important incremental surgical and oncological developments over the past decades. Localized disease is highly treatable with multimodal surgical and oncological therapy. Prognosis is dependent on several factors with tumour stage at diagnosis being the most important. Furthermore, curative treatment is highly dependent on radical surgical r

Some plants use food bodies to attract ants that then provide protection from herbivory. A brief report from 1898 describes the myrmecophilic plant Leea aculeata Bl. as bearing food bodies on its young shoots, which accumulate when they are not harvested by ants. However, ant efficacy in deterring herbivores and consequences for herbivory rates remain unknown. Here we investigate (1) which ant tax

A hybrid combining T-matrix method and electric field integral equation is used to formulate fundamental bounds on radiation efficiency of an implanted antenna. Resulting quadratic optimization problem is solved using a dual formulation. The results present the versatility of the described computational scheme and show the optimal current densities that are the least impaired by dissipation in the

An algebraic link between transition matrix and impedance matrix is utilized in this work to unify characteristic mode decomposition originally proposed by Garbacz with a framework proposed later on by Harrington and Mautz. The resulting formulation is unique to all method of moments formulations, valid for all linear and lossless materials, and has many favorable properties. The unified prescript

A reflective metasurface with reconfigurable beam is proposed for indoor wireless communications. It consists of 8 × 8 unit cells with tunable capacitors. By varying the capacitances, the reflective phase across the metasurface can be designed to facilitate different reflective angles for an incident wave. The simulation results show that the proposed reflective metasurface can deflect the incomin

Massive multiple-input multiple-out (MIMO) technology and mm wave are important technologies in 5G/6G to enhance the spectrum efficiency and system capacity. However, it has a lot of challenges in mm wave range, such as high hardware cost and power consumption in such systems. Hybrid beamforming is an interesting solution with less number of RF transvers than antennas. In this paper, we will prese

This study investigates a missing value imputation approach for longitudinal growth data in pediatric studies from multiple countries. We analyzed a combined cohort from five natural history studies of type 1 diabetes (T1D) in the US and EU with longitudinal growth measurements for 23,201 subjects. We developed a multiple imputation methodology using LMS parameters of CDC reference data. We measur

The recent years have witnessed science taking gigantic strides and achieving milestones in the areas which were previously rendered to be difficult. Advancements such as the culmination of the Human Genome Project and the successful use of gene therapy have shown how science can be used to alleviate human diseases and benefit society. While basic scientific knowledge is increasing at a remarkable

Atmospheric new-particle formation (NPF) affects climate by contributing to a large fraction of the cloud condensation nuclei (CCN). Highly oxygenated organic molecules (HOMs) drive the early particle growth and therefore substantially influence the survival of newly formed particles to CCN. Nitrogen oxide (NOx) is known to suppress the NPF driven by HOMs, but the underlying mechanism remains larg

The role of biotechnology as a forerunner in the pathway of revolution of human lives has been promising in the recent past. The achievements of biotechnology in the bio-medical front encompass various products like novel vaccines, diagnostic devices, and novel therapeutic strategies. This chapter deals with the principles and processes involved in the attainment of therapeutic tools and treatment