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Despite significant progress in oncology research, pancreatic cancer remains inherently difficult to treat, and the mechanisms underlying therapeutic resistance remain unresolved. Decorin (DCN), a member of the family of small leucine-rich proteoglycans, has emerged as a versatile actor in various malignant diseases. The aim of this study was to further explore the potential clinical significance
This paper addresses the path-tracking problem of time-optimal trajectories under model uncertainties, by proposing a real-time predictive scaling algorithm. The algorithm is formulated as a convex optimization problem, designed to balance the trade-off between improving feasibility and time optimality of a trajectory. The predicted trajectory is scaled based on the presence of path segments that
Dexterous in-hand manipulation offers significant potential to enhance robotic manipulator capabilities. This paper presents a sensori-motor architecture for in-hand slip-aware control, being embodied in a sensorized gripper. The gripper in our architecture features rapid closed-loop, low-level force control and is equipped with sensors capable of independently measuring contact forces and sliding
Arbetets syfte är att genom intervjuer ta reda på hur viktigt samverkan och företagsamhet är för alla musiker och kompositörer. Hur hör detta ihop med lyssnande och samverkan i repetitions- eller konsertsalen? Vad tycker dirigenten är viktigt för att driva en orkesterrepetition framåt? Vilken väg ska en kompositör gå för att komma i kontakt med konserthusen? Med intervjuer av kollegor och professoThe aim of the work is to find out through interviews how important collaboration and entrepreneurship are for all musicians and composers. How does this relate to listening and collaboration in the rehearsal or concert hall? What does the conductor think is important to drive an orchestral rehearsal forward? What route should a composer take to get in touch with concert halls? Through interviews
Background: The biodistribution of PSMA-ligands is of interest in radionuclide therapy planning. We investigated the variability of [18F]PSMA-1007 uptake in organs at risk and in relation to tumour burden in prostate cancer patients. Methods: A total of 1086 patients who underwent PSMA PET-CT for staging or recurrence of prostate cancer were included. Total lesion volume (TLV) and total lesion upt
Context. The nuclear stellar disc (NSD) is a rotating, disc-like structure in the Galactic centre; it is believed to have a distinct star formation history and a predominantly old stellar population. However, its formation history and evolutionary links to other structures in the Galactic centre remain uncertain. Studying the chemical evolution of the NSD could provide new insights into this regio
Background: Although Kirsten rat sarcoma virus (KRAS) mutations represent the most frequent oncogenic driver alterations in Caucasian lung adenocarcinoma (LADC) patients, their impact on immune phenotype and tumor morphology is largely unexplored. Here, we investigated the associations between KRAS mutation subtypes, immune landscape, and tumor heterogeneity in surgically treated LADC, with a part
Purpose: Cancer affects a great number of people during working life, and tailored interventions targeting this population are important. The present study, focused on the developmental phase of a work-oriented intervention, aimed to describe work-related experiences and needs among people undergoing curative cancer therapy. Methods: People (n = 22, age md 55 years, range 39–64, purposive sampling
Objectives: This work aims to present epidemiological data on penile cancer from the Nordic region (Denmark, Finland, Iceland, Norway, Sweden) and discuss the results in light of the present knowledge and possible future treatment strategies. Patients and Methods: All patients diagnosed with penile cancer in the Nordic countries between 2000 and 2022 were identified in the NORDCAN database. Data o
The goal of the VAST challenge 2019 Mini Challenge 2 was to visualize radioactive contaminations measured by mobile and static sensors and their changes over time, allowing city officials to determine the severity of the leakage at the city's nuclear power plant. We propose cpmViz, a web-based tool that allows for interactive data exploration of the sensor readings in both of the spatial and tempo
BACKGROUND: Clinical guidelines recommend different revascularization strategies for nonculprit lesions in patients with ST-segment-elevation myocardial infarction (STEMI) versus non-STEMI (NSTEMI). Whether the prevalence of untreated high-risk vulnerable plaques differs in STEMI and NSTEMI and affects their outcomes is unknown. METHODS: In PROSPECT II (Providing Regional Observations to Study Pre
Incidence of early-onset (< 40 years) type 2 diabetes (T2D) is increasing. While multiple risk factors have been identified, particularly obesity and low socioeconomic status, early-life factors are hypothesised to play a role via fetal programming. We investigated sociodemographic and early-life factors in relation to early-onset T2D using a family-based design that accounts for shared genetic an
Nomenclature for the disease widely known as Sjögren syndrome has proven unsatisfactory. Patients have perceived ‘syndrome’ as indicative of a vague collection of symptoms, prompting the Sjögren’s Foundation to abandon the term. Furthermore, the traditional distinction between ‘primary’ and ‘secondary’ forms fails to account for the complex interplay between overlapping autoimmune diseases. Follow
Background: Concern was raised within the International Contact Dermatitis Research Group (ICDRG) regarding the scoring of weak allergic versus doubtful patch test reactions. Objective: To investigate the degree of uniformity in patch test reading. Methods: Five series of fictive contact dermatitis cases were written up by the study organizer and presented to expert participants. Each series was s
Introduction: South Africa has one of the highest incidence rates of notified tuberculosis (TB) in the world. Achieving TB control requires strengthening treatment and support services. The implementation of differentiated delivery models can be used to improve service quality and enhance retention in care. This study aimed to identify treatment and support delivery preferences among people on TB
This paper examines the emerging concept of hybrid intelligence, the collaboration between humans and AI, and its growing importance in sensemaking processes across diverse organizational contexts. While hybrid intelligence offers significant potential for progress, the integration of responsibility into this collaborative framework remains a crucial challenge. Current research often explores huma
Hematopoietic stem and progenitor cells (HSPC) from mobilized blood are the preferred graft source for allogeneic and autologous stem cell transplantation. The efficiency of CD34+ cell mobilization with granulocyte colony-stimulating factor (G-CSF) varies significantly between individuals, but is reproducible across mobilization cycles within an individual, suggesting a genetic component, a hypoth
Background: Head and neck cancer patients often experience muscle wasting due to malnutrition and the hypermetabolism of cancer. For those undergoing total laryngectomy (TL), there is the potential for peri-operative complications. Sarcopenia has gained recognition as a prognostic factor in head and neck cancer. However, there is marked variability in the ways sarcopenia is defined and poor charac
Background: Preparing retrospective dose data for risk modeling using large study cohorts can be time consuming as it often requires patient-wise manual interventions. This is especially the case when considering organs at risk (OARs) not systematically delineated historically. Therefore, we aimed to develop and test a semi-automated workflow for cohort-wise preparation of radiotherapy data from t
