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Background: A previously discovered mutant of Saccharomyces cerevisiae alcohol dehydrogenase 1 (Adh1p) was shown to enable a unique NADH-dependent reduction of 5-hydroxymethylfurfural (HMF), a well-known inhibitor of yeast fermentation. In the present study, site-directed mutagenesis of both native and mutated ADH1 genes was performed in order to identify the key amino acids involved in this subst

The present study describes the anthropometrics of the Swedish workforce, aged 18-65, and compares the measurements with data collected four decades earlier. This anthropometric information is based on measurements of a total of 367 subjects, 105 males and 262 females. Of the 367 subjects, 268 responded to advertisements (Study A) and 99 were randomly selected from a community register (Study B).

This 10-week study assessed the efficacy of atomoxetine in combination with psychoeducation compared to placebo and psychoeducation in the improvement of Quality of Life in Swedish stimulant-naive children and adolescents with attention deficit/hyperactivity disorder. A total of 99 patients were treated with atomoxetine (49 patients) or placebo (50 patients) for 10 weeks and assessed regarding bro

Popular Abstract in Swedish I vår kropp genereras konstant ett stort antal nya blodceller för att ersätta de som går förlorade. Olika sorters blodceller är ansvariga för att transportera syre till alla våra vävnader, hjälpa till med blodets koagulering vid skador och att slåss mot infektioner orsakade av bakterier och virus. All blodceller härstammar från en liten population med blodstamceller somHematopoiesis is the process of blood formation from a limited pool of hematopoietic stem cells (HSCs). These rare stem cells can both self-renew to maintain the HSC pool, and differentiate to continuously replenish lost blood cells. The mechanisms of HSC regulation are not fully known. The aim of this thesis was to study the role of the Hippo signaling pathway in HSCs. The Hippo pathway is a newl

This thesis focuses on the development and testing of electrocardiographic (ECG) methods to diagnose and characterize myocardial ischemia, infarction and fibrosis (scar). The goal is to provide improved decision support to physicians regarding the optimal selection of patients for two costly, invasive therapies – percutaneous coronary intervention (PCI) for patients with acute myocardial infarctio

Many animals search for potential mates or prey using a perch-and-sally strategy. The success of such a strategy will depend on factors that affect the observer's ability to detect a passing resource item. Intrinsic factors (e.g., eye structure and physiology) have received much recent attention, but less is known about effects on object detection in nature and extrinsic factors such as size, colo

Objectives The study investigated the noise exposure in a group of Danish school teachers. The aims were to investigate if noise posed a risk of impairment of hearing and to study the association between classroom acoustical conditions, noise exposure, vocal symptoms, and cognitive fatigue. Methods Background noise levels, vocal load and speaking time were measured on 35 teachers during actual cla

Popular Abstract in Swedish När vi äter ökar nivån av blodsocker (blodglukos) i blodet. Glukos forslas i blodet till målvävnader, såsom fett och skelettmuskel, där det används som energi. Men för att glukos ska kunna tas upp av målvävnaden krävs insulin. Insulin är ett hormon som produceras av beta-celler i bukspottkörtelns Langerhanska öar, vars sekretion ut i blodet regleras av blodglukos. Då deType 2 diabetes (T2D) is a condition of high blood glucose levels due to insulin resistance and defective insulin secretion. Impaired insulin secretion plays a major role in the pathophysiology of T2D, it is mainly attributed to beta cell function i.e. failure to secrete insulin or reduced beta cell mass. The exocytotic process is crucial for beta cell function and its dysregulation leads to impai

In neurophysiology, investigating brain connectivity within and between different brain structures is of fundamental importance for understanding nervous system function and its relation to behavior. Yet, parallel recordings in multiple brain structures is highly challenging, especially in rodents, which are most commonly employed in neurophysiological research but rather small in size. In this st

In public international law, EU law, and national law there are numerous rules and principles stipulating the recognition of foreign administrative decisions. The article explores duties to recognise foreign administrative decisions, the possible limitations of such duties and the handling of cases involving recognition. Recognition of a foreign administrative decision means a form of transfer of

A single antenna based virtual antenna array at the receiver can be used to find direction of different incoming radio signals impinging at the receiver. In this paper, we investigate the performance of random 3D virtual antenna arrays for DoA estimation. We have computed a Cramer-Rao Lower Bound (CRLB) for DoA estimation if the true antenna positions are not known, but these are estimated with an

The azimuthal anisotropy coefficients v2 and v4 of p 0 and. mesons are measured in Au + Au collisions at root s(NN) = 200 GeV as a function of transverse momentum p(T) (1-14 GeV/c) and centrality. The extracted v(2) coefficients are found to be consistent between the two meson species over the measured p(T) range. The ratio of v(4)/v(2)(2) for pi(0) mesons is found to be independent of p(T) for 1-

In Kenya, the government is promoting high-value and drought resistant crop varieties in an effort to reduce poverty in rural areas. Sugar beet is one such crop. This study was conducted with two objectives: 1) to assess the opportunities and challenges for sugar beet cultivation and adoption in the Nyandarua district of Kenya and 2) to assess whether sugar beet adoption can offer an opportunity f

Background: Assessing left ventricular (LV) dysfunction by echocardiography in ICU patients is common. The aim of this study was to investigate mitral annular plane systolic excursion (MAPSE) in critically ill patients with shock and its relation to LV systolic and diastolic function, myocardial injury and to outcome. Methods: In a prospective, observational, cohort study we enrolled 50 patients w

Accurately reconstructing the rate of movement and extent of eolian dunes over thousands of years is a challenging endeavor. In this paper, we refine the methodology for utilizing lakes and bogs downwind of dune fields as precise recorders of past eolian activity. Sediment cores from two Allegan County lakes and one bog associated with dunes were studied to evaluate the importance of the various s

The aim of the present study was to explore the ability of personality to predict academic performance in a longitudinal study of a Swedish upper secondary school sample. Academic performance was assessed throughout a three-year period via final grades from the compulsory school and upper secondary school. The Big Five personality factors (Costa & McCrae, 1992) - particularly Conscientiousness

The use of performance enhancing drugs, especially anabolic androgenic steroids (AAS) has emerged as a social problem outside competitive sports, linked to substance abuse and crime. The purpose of this article is to analyze the use of doping and attitudes to doping outside the competitive sports context in relation to age, gender, ethnicity, so¬cio-economic status, and branch of sport. The articl