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Background Brain metastases are a common complication in cancer, particularly in patients with breast cancer, lung cancer, and melanoma, and are associated with poor prognosis. Understanding the spatial organization of tumor and immune cells is critical for uncovering the mechanisms of metastasis. Spatial transcriptomics technologies now allow gene expression profiling while preserving tissue arch
Glioblastoma (GBM) remains one of the most aggressive and treatment-resistant brain tumors, with limited systemic therapeutic options and high recurrence rates. New treatment modalities in oncology, including antibody-drug conjugates and CAR-T cells, target the tumor cell surfaceome. However, despite extensive genomic and transcriptomic profiling, actionable surface antigens for targeted immunothe
Alzheimer’s disease (AD) is characterized by amyloid-β (Aβ) plaque deposition, tau pathology, and neuroinflammation, with genetic variants in the apolipoprotein E (APOE) gene representing the strongest risk factor for late-onset AD. Microglia, the brain’s resident immune cells, are increasingly recognized as central to disease progression through their roles in neuroinflammation and Aβ clearance.
Adeno-associated viruses (AAVs) are among the most promising vectors for safe and effective gene delivery in therapeutic applications. However, engineering functional AAV capsids remains a major challenge due to the vast sequence space, unpredictable biological performance, and limited translational success of many variants. Machine learning offers a powerful strategy to address these limitations
A high-throughput method for the fabrication of ordered arrays of Au nanoparticles is presented. It is based on pulsed electrodeposition into porous anodic alumina templates. In contrast to many synthesis routes, it is cyanide-free, prior separation of the alumina template from the aluminium substrate is not required, and the use of contaminating surfactants/capping agents often found in colloidal
Post-heroic perspectives on leadership, which approach leadership as process, practice and a relational phenomenon, have shifted the theoretical understanding from individual characteristics to significant so-called moments of leadership, where direction emerges, and actions are re-oriented and organized. However, despite considerable theoretical development, research struggles to explore these pr
This book was conceived in the context of a workshop at the Lund University Malmö Theatre Academy, where we used our bodies to create patterns based on prompts such as if the work we do imagines sustainability more in terms of harmony or more in terms of conflict, or how we orient ourselves on a continuum of past, [present] and future. Important to note is that the patterns were ever-changing, not
Purpose: The virtualization of work has been high on the agenda during the new millennium, increasingly so after the pandemic. In this transition, co-working spaces (CWS) are often proposed to be the future-proof solution. The purpose of this paper is to explore how hybrid and virtual solutions are portrayed in co-working literature and whether they are shaping CWS in practice. Design/methodology/
Biogas production from a mix of easily fermentable and fibrous energy crops was evaluated and compared for two different process types. The processes were a batch two-stage leach bed combined with an upflow anaerobic sludge blanket (UASB) process and a semi-continuous one-stage continuously stirred tank reactor (CSTR) process The specific methane yields after a processing time of 29-30 days were 2
A report of the Sweden new government on the future for bioenergy is presented. The report state that the agriculture sector supplies 1.5 TWh of biomass energy to the Swedish energy system in the form of wheat, rapeseed, and some willows. A report discloses the fact that agriculture can play an important role in the development of Swedish energy system in the future. The most profitable crops for
While leadership is generally understood as an agentic process, there are divergent positions in the literature regarding the extent to which agency is to be understood as centralized in individuals and individual actions or distributed among actors and located in the collaborative process itself. In this study, we align with post-heroic studies of the realization of moments of leadership through
Akademiska utbildningar i främmande språk är på många sätt ovanliga utbildningar i högre utbildning. Utbildningarna har krav på sig att vara vetenskapligt breda samtidigt som det finns stora behov av och förväntningar på grundläggande språkfärdighetsträning. Främmande språk studeras med flera olika syften, både för bredd och djup, och av studenter i olika skeden av livet och med heterogen bakgrund
This chapter aims to establish a conceptual framework for analyzing the EU legal space and its core-periphery dynamics, notably the extension of EU legal frameworks and policies beyond the territorial borders of the Union. It investigates how the EU legal space is defined, how its cores and peripheries are structured, and how they interact, evolve, and influence each other. The chapter argues that
Om Bayeuxtapeten
In 2015 the Rockefeller Foundation-Lancet Commission defined the concept of planetary health as built on an ecological model that integrates the material, biological, social, and cultural aspects of public health and accepts the complexity and non-linearity of the dynamics of natural systems. The zoonotic COVID-19 pandemic hastened this awaking to the symbiotic nature of planetary health politics
Denna avhandling undersöker hur Halle-pietismen blev en central plats för framväxten av pastoralt biomaktutövande, där själavård och hälsostyrning systematiskt vävdes samman. Med fokus på August Hermann Franckes och Christian Friedrich Richters rationliteter samt den institutionella ordningen i Die Franckeschen Anstalten (1698–1759) utmanar studien den dominerande berättelsen om att biomakt och fo
