INTRODUCTION: Ascertainment of the pattern and temporal change of biomarkers in preclinical (asymptomatic) sporadic Alzheimer's disease (AD) will increase knowledge about early pathogenesis and facilitate interventional therapeutic trials.METHODS: In this prospective longitudinal study, repeated cerebrospinal fluid (CSF) collections and cognitive evaluations were performed in cognitively healthy e

INTRODUCTION: Matrix metalloproteinases (MMP) are believed to be involved in the pathologic processes behind Alzheimer's disease (AD). In this study, we aimed to examine the cerebrospinal fluid (CSF) levels of MMPs and tissue inhibitors of metalloproteinase-1 (TIMP-1) in individuals with AD dementia and cognitively healthy elderly individuals, and to investigate their relationship with established

BACKGROUND: Breast cancer (BC) is the most common type of cancer in women worldwide. Post-treatment, patients suffer from side effects and have various rehabilitation needs, which means that individualization is fundamental for optimal rehabilitation. This systematic review (SR) of SRs aims to evaluate the current evidence on rehabilitation interventions in female patients following BC treatment.M

Vår sol är endast en av hundra miljardtals stjärnor i vår Galax. Den är en levande stjärna som ändras från dag till dag. Astronomer studerar solenss yta och dess inne med dedikerade solteleskop.Andra stjärnor därute sitter ofattbart långt från oss, men vi studerar dem ändå. I denna visning upptäcker vi hur stjärnhimlen ändras från en säsong till en annan och vi ser hur stjärnornas rörelse kan hjälOur sun is only one of hundreds of billions in our galaxy. It is a living star and it changes from one day to the next. Astronomers study the solar surface and its interior with dedicated solar telescopes.Other stars are more distant, but we study them also. In this planetarium show we discover how the night sky changes from one season to another and we see how the movement of the stars can lead u

Asteroiden 3122 Florence flög förbi Jorden i början av September 2017 och astronomer lyckades fånga bilder av asteroiden som visar att den har två månar kretsande runt om sig. I denna visning diskuterar vi vad vi vet om asteroiderna i vårt solsystem, hur stora de är, hur många och vad vi skulle kunna göra om en asteroid var på väg mot Jorden.The asteroid 3122 Florence flew past the Earth in early September 2017 and astronomers managed to capture images showing that it had two moons in orbit around it.In this planetarium show we discuss the asteroids in our Solar System, what we know about them, how large they are, how many there are and what we could do if we discovered one on a collision course with Earth.

Purpose: The platelet-derived growth factor (PDGF) signalling pathway is often dysregulated in cancer and PDGF-receptor expression has been linked to unfavourable prognostic factors in breast cancer (e.g. ER negativity, high Ki67 and high grade). This study aimed to evaluate the expression of PDGFRα, PDGFRβ and ligand PDGF-CC in breast cancer in relation to molecular subtypes and prognosis. Method

Vad kan du se när du tittar upp nattetid? Stjärnor, planeter, månen, kanske även stjärnfall? Känner du igen några stjärnbilder?I denna interaktiva planetariumföreställning bjuder vi våra yngsta besökare på en upptäcktsfärd bland natthimlens stjärnor innan vi lämnar Jorden och flyger ut i rymden för att tillsammans besöka solsystemets olika planeter.What can you see when you look up at night? Stars, planets, the Moon, maybe even a shooting star? Do you know any of the constellations?In this interactive planetarium show we invite your youngest visitors to explore the night sky and to fly out into the Solar System to visit the planets.

Studies on the acquisition of French liaison have primarily focused on monolingual children or adult second language (L2) learners in a university context. To bridge the gap between these two populations, the present article focuses on child L2 (cL2) learners – a particularly interesting group, since they are L2 learners who, unlike adults, do not have access to writing. How does liaison develop i

Mycket forskning inom olika vetenskapsområden har länge haft fokus på social­tjänstens insatser för barn i olika avseenden och även på privatiseringen av verkstäligheten av vården. Det saknas däremot studier som fokuserar på förekomsten av privata konsulter som genomför barnavårdsutredningar. Det innebär också att det idag är oklart vilka konsekvenser en sådan förändring innebär för socialtjänsten

This chapter explores the initial development of VOT in three Swedish-speaking learners of French (age of onset: 3;0-3;5). Swedish uses long lag and short lag/lead to differentiate voiceless and voiced stops word-initially (Helgasson & Ringen 2008; Sundberg & Lacerda 1999). In French this distinction is made using short lag and lead (Kessinger och Blumstein 1997). Through a memory game wor

Otitis media is a common disease in childhood. In adults, the disease is relatively rare, but more frequently associated with complications. Possible reasons for this discrepancy are age-related differences in pathogen exposure, anatomy of the Eustachian tube and immune system. The objective of this study was to analyze the relationship between age and the mucosal immune system in the middle ear.

Background: It has been established that patients with chronic rhinosinusitis with nasal polyps (CRSwNP) often have co-existing asthma. Objective: We aimed to test two hypotheses: (i) upper and lower airway inflammation in CRSwNP is uniform in agreement with the united airways concept; and (ii) bronchial inflammation exists in all CRSwNP patients irrespective of clinical asthma status. Methods: We

Hypothesis: A number of bone-related genes may be responsible for the unique suppression of perilabyrinthine bone remodeling. Background: Bone remodeling is highly inhibited around the inner ear space most likely because of osteoprotegerin (OPG), which is a well-known potent inhibitor of osteoclast formation and function. However, other signaling molecules may also be responsible for the inhibitio

Conclusion: The endolymphatic sac is part of the membranous inner ear and is thought to play a role in the fluid homeostasis and immune defense of the inner ear; however, the exact function of the endolymphatic sac is not fully known. Many of the detected mRNAs in this study suggest that the endolymphatic sac has multiple and diverse functions in the inner ear. Objectives:The objective of this stu