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Elucidating the nanostructure of small interfering RNA-loaded lipidoid-polymer hybrid nanoparticles

We analyzed the structural and material properties of small interfering RNA (siRNA)-loaded lipid-polymer hybrid nanoparticles (LPNs) containing ionizable lipidoid and poly(dl-lactic-co-glycolic acid) (PLGA) using small-angle X-ray scattering, cryogenic transmission electron microscopy, polarized light microscopy, the Langmuir monolayer methodology, differential scanning calorimetry, and attenuated

Ephemeral space sanctification and trespassing gender boundaries in a Muslim city

A distinct feature of Muslim cities is demarcated separation between zones of public economic and private domestic activities. Such spatial distinction has been the organic extension of a social structure with limited presence of women in public zones. However, separation of spaces in the Muslim city and the way it is utilized, shaped and reproduced by men and women is not a simple case of dividin

The water sensitive future of Lahijan

The emergence of the modern urban water system in Iran, albeit facilitated access to clean water and accelerated discharge of waste- and stormwater, it left some negative imprints on country’s urban and natural environment. Among which larger stress on natural water cycles and pollution of water resources are of great importance. More importantly, such impacts are occurring when cities are going t

Bidirectional association between physical activity and sleep in healthy Japanese super-seniors : the Japan Healthy Aging Study (J-HAS)

To address the challenges of an ageing population, it is important to promote health by identifying factors for healthy ageing. The aim of this study was to investigate the bidirectional association between physical activity (PA) and sleep in healthy Japanese super-seniors over the age of 80. For approximately 1 year, 124 participants wore wearable devices and answered daily lifestyle questionnair

"The Good, the Bad, or the Ugly? The Choice of Legal Basis in EU Digital Finance"

This article analyses the choice of legal basis for measures under the EU’s digital finance strategy. In this area, a new regulation has recently been introduced concerning markets in crypto-assets (MiCA). The package for a digital finance strategy also includes a Digital Operational Resilience Act (DORA) as well as a regulation on distributed ledger technology (DLT). All these measures are adopte

CyberROAD : a cybersecurity risk assessment ontology for automotive domain aligned with ISO/SAE 21434:2021

The automotive domain is becoming increasingly complex through the integration of new technologies. As a result, cybersecurity is recognized as a pressing issue. This study focuses on the ISO/SAE 21434:2021 standard for road vehicles cybersecurity engineering, evaluating the effectiveness of the standard’s risk assessment approach. The standard suggests a set of assessment steps, and previous rese

SGLT2 Inhibitors in Patients with Urogenital Malformations and Urinary Diversions : Risks, Benefits, and Clinical Considerations

Background: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are increasingly used in patients with type 2 diabetes, chronic kidney disease, and heart failure. However, their safety and efficacy in patients with congenital or surgically altered urogenital anatomy remains underexplored. Methods: We conducted a narrative review of current evidence regarding the use of SGLT2i in patients with urina

Experimental toolkit to study the oncogenic role of WNT signaling in colorectal cancer

Colorectal cancer (CRC) is linked to the WNT/β-catenin signaling as its primary driver. Aberrant activation of WNT/β-catenin signaling is closely correlated with increased incidence, malignancy, poorer prognosis, and even higher cancer-related death. Research over the years has postulated various experimental models that have facilitated an understanding of the complex mechanisms underlying WNT si

A human-centric approach to energy justice : embedding agency and capabilities in transitions discourse

This paper addresses the critical gap in understanding the justice implications of renewable energy transitions, particularly concerning the agency of different actor groups, including marginalised and local communities. Given the urgency of transitioning to renewables to mitigate climate risks, it highlights the need for more human centric approaches to ensure equitable outcomes. In this context,

Evaluation of long-term carbon dynamics in a drained forested peatland using the ForSAFE-Peat model

Management of drained forested peatlands has important implications for carbon budgets, but contrasting views exist on its effects on climate. This study utilised the dynamic ecosystem model ForSAFE-Peat to simulate biogeochemical dynamics over two complete forest rotations (1951–2088) in a nutrient-rich drained peatland afforested with Norway spruce (Picea abies) in southwestern Sweden. Model sim

Utilizing artificial intelligence and medical experts to identify predictors for common diagnoses in dyspneic adults: A cross-sectional study of consecutive emergency department patients from Southern Sweden

Objective Half of all adult emergency department (ED) visits with a complaint of dyspnea involve acute heart failure (AHF), exacerbation of chronic obstructive pulmonary disease (eCOPD), or pneumonia, which are often misdiagnosed. We aimed to create an artificial intelligence (AI) diagnostic decision support tool to detect patients with AHF, eCOPD, and pneumonia among dyspneic adults at the beginn