Sökresultat

Filtyp

Din sökning på "*" gav 548254 sökträffar

Sacred (re)collections : Culture, space and boundary negotiation in Turkish-Islamic memory politics

This article discusses how state-organized, memory-cultural production drawing on religious signifiers contributes to a sacralization of Turkish public memory institutions and public space. This reinforces an Islamic-nationalist imagination of contemporary Turkey. The article explores state-led, disciplinary interventions in museal space (the Sacred Trusts exhibition of relics at Topkapı Palace MuThis article discusses how state-organized, memory-cultural production drawing on religious signifiers contributes to a sacralization of Turkish public memory institutions and public space. This reinforces an Islamic-nationalist imagination of contemporary Turkey. The article explores state-led, disciplinary interventions in museal space (the Sacred Trusts exhibition of relics at Topkapı Palace Mu

Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity

The enzyme NUDT15 efficiently hydrolyses the active metabolites of thiopurine drugs, which are routinely used for treating cancer and inflammatory diseases. Loss-of-function variants in NUDT15 are strongly associated with thiopurine intolerance, such as leukopenia, and pre-emptive NUDT15 genotyping has been clinically implemented to personalize thiopurine dosing. However, understanding the molecul

Perinatal inflammation relates to early respiratory morbidity and lung function at 12 years of age in children born very preterm

Aim: Very preterm birth may be associated with lung function impairment later in life. It is not known if this is caused by prematurity per se or by associated perinatal events, such as maternal–foetal inflammation and severity of early neonatal lung disease. We assessed these factors in a prospective cohort of very preterm infants followed from birth to middle school age. Methods: In 71 infants w

Power Scaling Laws for Radio Receiver Front Ends

In this paper, we combine practically verified results from circuit theory with communication-theoretic laws. As a result, we obtain closed-form theoretical expressions linking fundamental system design and environment parameters with the power consumption of analog front ends (AFEs) for communication receivers. This collection of scaling laws and bounds is meant to serve as a theoretical referenc

Sleep duration is associated with protein biomarkers for cardiometabolic health : A large-scale population study

Sleep problems and short sleep duration have been linked to adverse health effects, such as cardiovascular disease and diabetes, but the mechanisms are not fully understood. Finding biomarkers could explain mechanistic pathways and help in understanding relationships between sleep and cardiometabolic health. The aim was to assess if sleep duration and sleep quality affect the cardiometabolic-relat

Detection of Non-Small Lung Cell Carcinoma-Associated Genetic Alterations Using a NanoString Gene Expression Platform Approach

In non-small cell lung cancer (NSCLC), mutation detection and fusion gene status are treatment predictive and, hence, key factors in clinical management. Lately, alternate splicing variants of MET have gained focus as NSCLC tumors harboring a MET exon 14 skipping event have proven sensitive toward targeted therapy. Reliable methods for detection of genetic alterations in NSCLC have proven to be of

Ultrasound Assisted Alkaline Pre‐treatment Efficiently Solubilises Hemicellulose from Oat Hulls

The establishment of sustainable bioeconomies requires the utilization of new renewable biomaterials. One such material currently seen as a waste product is oat hulls. Oat hulls exhibit a great potential for the production of dietary fibres due to their exceptionally large hemicellulose content (35%). Their recalcitrant structure however requires a suitable pre-treatment method to access and proce

Biotechnological production of the European corn borer sex pheromone in the yeast Yarrowia lipolytica

The European corn borer (ECB) Ostrinia nubilalis is a widespread pest of cereals, particularly maize. Mating disruption with the sex pheromone is a potentially attractive method for managing this pest; however, chemical synthesis of pheromones requires expensive starting materials and catalysts and generates hazardous waste. The goal of this study was to develop a biotechnological method for the p

New Kids on the Block : The Emerging Role of YAP/TAZ in Vascular Cell Mechanotransduction

YAP and TAZ are transcriptional coactivators controlled by the Hippo signaling pathway and by actin dynamics, and that are critical for cell growth and organ size control. YAP and TAZ are exquisitely sensitive to mechanical cues, such as substrate stiffness and shear stress, and the realization is growing that they play roles in arterial remodeling and aneurysm formation. This chapter discusses ho

Boronic Acid Functionalized Nanosilica for Binding Guest Molecules

Dendritic fibrous nanosilica (DFNS) has very high surface area and well-defined nanochannels; therefore, it is very useful as supporting material for numerous applications including catalysis, sensing, and bioseparation. Due to the highly restricted space, addition of molecular ligands to DFNS is very challenging. This work studies how ligand conjugation in nanoscale pores in DFNS can be achieved

Putative ligand binding sites of two functionally characterized bark beetle odorant receptors

Background: Bark beetles are major pests of conifer forests, and their behavior is primarily mediated via olfaction. Targeting the odorant receptors (ORs) may thus provide avenues towards improved pest control. Such an approach requires information on the function of ORs and their interactions with ligands, which is also essential for understanding the functional evolution of these receptors. Henc

Segregation dynamics of a Pd-Ag surface during CO oxidation investigated by NAP-XPS

The dynamic changes in composition in the near-surface region of a Pd75%Ag25%(100) single crystal were monitored using near-ambient pressure x-ray photoelectron spectroscopy (NAP-XPS) during CO oxidation under oxygen rich conditions at a total pressure of 1.1 mbar. Six CO oxidation temperature cycles were investigated at different heating rates and maximum temperatures of 450 °C or 600 °C. It was

Assessment of future EV charging infrastructure scenarios for long-distance transport in Sweden

Over the last two decades, electrification has gained importance as a means to decarbonise the transport sector. As the number of Electric Vehicles (EVs) increases, it is important to consider broader system aspects as well, especially when deciding the type, coverage, size and location of the charging infrastructure required. This article proposes a new approach using agent-based simulations to a

How to detect late-onset inborn errors of metabolism in patients with movement disorders - A modern diagnostic approach

We propose a modern approach to assist clinicians to recognize and diagnose inborn errors of metabolism (IEMs) in adolescents and adults that present with a movement disorder. IEMs presenting in adults are still largely unexplored. These disorders receive little attention in neurological training and daily practice, and are considered complicated by many neurologists. Adult-onset presentations of

The genus eriastichus la salle (Hymenoptera, eulophidae, tetrastichinae) in the neotropical region, introducing 48 new species

Our knowledge of the recently described genus Eriastichus La Salle is greatly enhanced with the addition of 48 new species: E. acribis sp. nov., E. aphritis sp. nov., E. cluridis sp. nov., E. coelotis sp. nov., E. co-lenis sp. nov., E. copalensis sp. nov., E. daptilis sp. nov., E. decoris sp. nov., E. denotatis sp. nov., E. derilis sp. nov., E. diadrys sp. nov., E. dotaensis sp. nov., E. drupis sp