The major histocompatibility complex (MHC) plays a central role in the vertebrate adaptive immune system and has been of long-term interest in evolutionary biology. While several protocols have been developed for MHC genotyping, there is a lack of transparent and standardized tools for downstream analysis of MHC data. Here, we present the r package mhctools and demonstrate the use of its functions

Lecanoraceae is one of the largest families of the Lecanoromycetes, with about 30 accepted genera, many of which, however, have uncertain status and/or circumscriptions. We assess the phylogenetic position of the genus Bryonora and its segregate Bryodina for the first time, using a six-locus phylogeny comprising the Lecanoraceae as well as closely related families. We find strong support for the p

Aims/hypothesis: Observational studies have found an increased risk of latent autoimmune diabetes in adults (LADA) associated with low birthweight and adult overweight/obese status. We aimed to investigate whether these associations are causal, using a two-sample Mendelian randomisation (MR) design. In addition, we compared results for LADA and type 2 diabetes. Methods: We identified 43 SNPs actin

Background: Endothelial and microvascular dysfunction are pivotal causes of major adverse cardiac events predicted by coronary flow reserve (CFR). Extracellular Vesicles (EVs) have been studied extensively in the pathophysiology of coronary artery disease. However, little is known on the impact of the non-coding RNA content of EVs with respect to CFR. Methods: We carried out a study among 120 pati

Background: Multimorbidity is a rising global phenomenon, placing strains on countries’ population health and finances. This systematic review provides insight into the costs of multimorbidity through addressing the following primary and secondary research questions: What evidence exists on the costs of multimorbidity? How do costs of specific disease combinations vary across countries? How do mul

Big Data analytics and Artificial Intelligence (AI) technologies have become the focus of recent research due to the large amount of data. Dimensionality reduction techniques are recognized as an important step in these analyses. The multidimensional nature of Quality of Experience (QoE) is based on a set of Influence Factors (IFs) whose dimensionality is preferable to be higher due to better QoE

The subject of the present thesis is children’s rights in the process of debt collection. The main focus of the thesis is article 3.1 of Convention on the Rights of the Child (CRC) and its legal relevance in proportionality tests prior to decisions on seizure and sales of houses and apartments in Swedish insolvency law. The thesis is based on two studies. One legal dogmatic study on Swedish enforc

Wetlands are an important carbon sink for greenhouse gases (GHGs), and embedding microbial fuel cell (MFC) into constructed wetland (CW) has become a new technology to control methane (CH4) emission. Rhizosphere anode CW–MFC was constructed by selecting rhizome-type wetland plants with strong hypoxia tolerance, which could provide photosynthetic organics as alternative fuel. Compared with non-plan

Background: Post-traumatic osteoarthritis (PTOA) does not currently have clinical prognostic biomarkers or disease-modifying drugs, though promising candidates such as dexamethasone (Dex) exist. Many challenges in studying and treating this disease stem from tissue interactions that complicate understanding of drug effects. We present an ex vivo human osteochondral model of PTOA to investigate dis

Background: In Sweden, core treatment for osteoarthritis is offered through a Supported Osteoarthritis Self-Management Programme (SOASP), combining education and exercise to provide patients with coping strategies in self-managing the disease. The aim was to study enablement and empowerment among patients with osteoarthritis in the hip and/or knee participating in a SOASP. An additional aim was to

Ammonia (NH3) has attracted significant attention as a promising hydrogen carrier and a carbon-free alternative fuel. Partial dissociation could convert part of ammonia to H2 and N2 before injecting the fuel into a combustor, thus overcoming the low reactivity and high NOx emission problems during the NH3 combustion. The pre-dissociated NH3 + air mixture has unburnt species NH3, H2, O2, and N2, th

Ki67 has potential clinical importance in breast cancer but has yet to see broad acceptance due to inter-laboratory variability. Here we tested an open source and calibrated automated digital image analysis (DIA) platform to: (i) investigate the comparability of Ki67 measurement across corresponding core biopsy and resection specimen cases, and (ii) assess section to section differences in Ki67 sc

This research investigated convective heat transfer and hydraulic resistance of smooth and corrugated double-tube heat exchangers at various flow rates from 60 L/h to 200 L/h. The inner tube with a thread structure is designed with three pitches, i.e., 4 mm, 6 mm and 8 mm. Nanofluids are used as tube-side fluids to analyze the enhancement of heat transfer on the inner tube side. Results show that

An experimental study to characterize properties controlling delamination of paperboard is presented. The normal and shear traction–separation laws are measured and evaluated using a double cantilever beam (DCB) and a split double cantilever beam (SCB) specimen. The DCB-experiments provides normal separation data in good agreement with results using alternative experimental techniques. From the me

Poland and polish courts have been the subject of much attention during recent years, because of alleged problems in relation to the organisation of justice in Poland. It has been claimed that new suggested legislation in Poland, and changes in the system for appointing judges, prevents courts in Poland from adjudicating justice in a fair and independent manner in accordance with the Rule of Law.

Ozonation of wastewater can reduce the release of organic micropollutants, but may result in the formation of undesirable by-products, such as bromate from bromide. Bromide is one of the most abundant ions in seawater, the primary precursor of bromate during ozonation, and the end product in microbial bromate reduction. Investigations were carried out to compare the concentration of bromide in was