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Genome-wide association studies have identified several risk loci for multiple myeloma (MM); however, the mechanisms by which they influence MM are unknown. Here by using genetic association data and functional characterization, we demonstrate that rs4487645 G>T, the most highly associated variant (P = 5.30 × 10-25), resides in an enhancer element 47 kb upstream of the transcription start site of

Orchid species are critically dependent on mycorrhizal fungi for completion of their life cycle, particularly during the early stages of their development when nutritional resources are scarce. As such, orchid mycorrhizal fungi play an important role in the population dynamics, abundance, and spatial distribution of orchid species. However, less is known about the ecology and distribution of orchi

Abstract: We demonstrate an all-optical Raman spin echo technique, using electromagneticallyinduced transparency (EIT) to create the pulses required for a spin echo sequence:initialization, pi-rotation, and readout. The first pulse of the sequence inducescoherence directly from a mixed state, and the technique is used to measure the nuclearspin coherence of an inhomogeneously broadened ensemble of

We present the PalCom Object Notation, a textual data representation format for communication between internet of things which support binary and textual data. The format does not require parsing of user data (or the “payload”) and is thus efficient to use also for large binary values such as digital images, audio and video as well as for short textual values. These can be mixed in the same messag

Purpose - The purpose of this paper is to present numerical investigation of the gas/vapor bubble dynamics under the influence of an ultrasonic field to give a more comprehensive understanding of the phenomenon and present new results Design/methodology/approach - In order to formulate the mathematical model, a set of governing equations for the gas inside the bubble and the liquid surrounding it

There are few studies on how social workers deal with cases regarding transnational surrogacy. Our study intends to contribute to filling this gap. In Sweden, surrogacy as an assisted reproductive technology method is not permitted. As a result, many prospective parents have turned abroad, mainly to India, for surrogacy. There are no laws regulating surrogacy in Sweden, and difficulties have arise

Purpose: It has been proposed that biological/chemical substances in the intestine might play a role in the occurrence and deterioration of perianal fistulas. Elimination of such unidentified factors from the lower gastrointestinal tract might offer a new strategy for the management of anal fistulas. The aim of this study was to evaluate the clinical effects on non-Crohn’s disease perianal fistula

The Fano line shape arises from the interference of two excitation pathways to reach a continuum. Its generality has resulted in a tremendous success in explaining the line shapes of many one-dimensional spectroscopies - absorption, emission, scattering, conductance, photofragmentation - applied to very varied systems - atoms, molecules, semiconductors, and metals. Unraveling a spectroscopy into a

Homelessness as a political and social dominion has a number of features that make it particularly difficult to tackle. In addition to being a wicked problem, homelessness offers several analytical avenues. How do these characteristics affect the evaluation of programmes and projects aspiring to combat homelessness? Dissimilar pictures and solutions regarding homelessness in the US and in European

Part of the justification for an integrated view of speech and gestures ( (( is their temporal coordination. Gestures generally coincide with or precede, but rarely follow lexical affiliate (McNeill, 1992). How synchrony impacts listeners remains less explored, despite potential relevance for video communication and virtual conversational agents. ERP studies suggest that temporal alignment affects

Background: Environmental lead exposure is a possible causative factor for increased blood pressure and hypertension, but large studies at low-level exposure are scarce, and results inconsistent. Objective: We aimed to examine the effects of environmental exposure to lead in a large population-based sample. Methods: We assessed associations between blood lead and systolic/diastolic blood pressure

Traditional chromatographic methods for the analysis of lignin-derived phenolic compounds in environmental samples are generally time consuming. In this work, an ultra-high performance supercritical fluid chromatography method with a diode array detector for the analysis of major lignin-derived phenolic compounds produced by alkaline cupric oxide oxidation was developed. In an analysis of a collec

We demonstrate crack-free ZnO/GaN distributed Bragg reflectors (DBRs) grown by hybrid plasma-assisted molecular beam epitaxy using the same growth chamber for continuous growth of both ZnO and GaN without exposure to air. This is the first time these ZnO/GaN DBRs have been demonstrated. The Bragg reflectors consisted up to 20 periods as shown with cross-sectional transmission electron microscopy.

On-line supported liquid membrane (SLM) extraction and microporous membrane liquid-liquid extraction (MMLLE) techniques for sample preparation of natural water samples have been developed for the determination of thiophanate-methyl (TM), carbendazim (MBC) and 2-aminobenzimidazole (2-AB) using reversed-phase HPLC. The combination of SLM extraction and MMLLE offers extraction conditions that makes i

An automated system with microporous membrane liquid-liquid extraction (MMLLE) combined with HPLC has been designed for the determination of Vinclozolin in aqueous matrices. In MMLLE a porous hydrophobic membrane separates an aqueous phase from an organic phase. The pores are filled with the organic solvent. In this work, MMLLE was performed in a flow system and coupled on-line to normal phase HPL

The decline of the two fungicides vinclozolin (formulation Ronilan FL) and triadimefon (formulation Bayleton Special) was studied in greenhouses. The decline of vinclozolin was also studied in climate chambers. In greenhouse experiments the fungicides were applied with either a low-volume sprayer or a high-volume sprayer, while in the climate chamber experiments the fungicide was applied with a pi

A new analysis procedure for fungicides has been developed gearing toward estimation of worker exposure in greenhouses. The procedure includes sampling on leaves, glass, and polymers using vinclozolin and triadimefon as model substances and starts with solvation of the fungicides with ethanol from the surface. It proceeds by collection of the solution on disks of cloth, disk extraction with excess