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When parametrizing multi-Higgs potentials, it is desirable to express its coefficients via observables. This is routinely done for the 2HDM, but this approach often fails in more elaborate models. Here, we show that the scalar sector of the CP4 3HDM, an intriguing model based on an order-4 CP symmetry, can also be parametrized in an observable-driven manner. The key feature that makes it work is t
The question of discretion in law is often framed as a technical question – how can we ensure that the decisions produced in administrative processes are accurate, predictable, non-discriminatory, free from bias, etc. If we conceive of discretion with this framing, then replacing human discretion with machine discretion seems eminently sensible.In this article, I question that framing of discretio
The x-ray absorption spectrum of the O2+ molecular cation is measured. The ions are stored in a cryogenically cooled radiofrequency ion trap and probed by tunable synchrotron radiation. The spectrum exhibits several salient features: a three-state composite π∗ resonance at the low-energy side followed by a two-component exchange split, a highly dissociative, σ∗ resonance pulled down well below the
BACKGROUND AND OBJECTIVE: There is no standardized regimen for follow-up after radical cystectomy (RC) for bladder cancer (BC). To address this gap, we conducted a multicenter study involving urologist members from the European Association of Urology (EAU) bladder cancer guideline panels. Our objective was to identify consistent post-RC follow-up strategies and develop a practice-based framework b
We propose and analyze a novel scheme based on LDPC codes for quantitative group testing. The key underlying idea is to augment the bipartite graph by introducing hidden non-binary variables to strengthen the message-passing decoder. This is achieved by grouping items into bundles of size q within the test matrix, while keeping the testing procedure unaffected. The decoder, inspired by some works
Implicit bias interventions, qua attempts to decrease implicit bias measures, are often indirect prejudice interventions. As such, they face a number of potential problems. In particular, implicit bias interventions are more susceptible to generate unforeseen side-effects, are more prone to overcompensation, and less clearly decrease prejudicial behaviour, than at least some direct prejudice inter
The Chromosome-Centric Human Proteome Project (C-HPP) is an international initiative. It aims to create a protein list expressed in human cells by each chromosomal and mitochondrial DNA to enhance our understanding of disease mechanisms, akin to the gene list generated by the Human Genome Project. Transmembrane protein 160 (TMEM160) is a member of the transmembrane proteins (TMEM) family. TMEM pro
At a time of increasing environmental changes and geopolitical tensions, the need for collaboration in the Arctic is greater than ever. Top-down initiatives such as the Arctic Council have contributed to important increased collaboration and science diplomacy. Similarly, bottom-up initiatives have also played a major role in establishing diplomacy among researchers with spin-offs at government lev
Importance: The 2023 American College of Rheumatology and American Association of Hip and Knee Surgeons Clinical Practice Guideline concluded that obesity alone should not delay joint replacement. Therefore, a substantially increased utilization of joint replacement among patients with obesity could be expected. However, patients with obesity are at increased risk of revision, posing unique challe
We study supercooled first-order phase transitions above the QCD scale in a wide class of conformal Majoron-like U(1)′ models that explain the totality of active neutrino oscillation data and produce a detectable stochastic gravitational wave background (SGWB) at LIGO, LISA and ET. We place constraints on the U(1)′ breaking scale and gauge coupling using current LIGO-Virgo-Kagra data. We find that
We investigate the electronic structure of high-density layers of Sb dopants in a silicon host, so-called Si:Sb δ-layers. We show that, in spite of the known challenges in producing highly confined Sb δ-layers, sufficient confinement is created such that the lowest conduction band states (Γ states, studied in depth in other silicon δ-layers), become occupied and can be observed using angle-resolve
PURPOSE: Adding salt to foods, a novel indicator for studying habitual sodium intake, has been positively associated with multiple diseases and mortality. However, little is known about its association with liver-related disorders. This study aimed to investigate the associations of adding salt to foods with risks of metabolic dysfunction-associated steatotic liver disease (MASLD), cirrhosis, and
Despite the prevalence of slavery in world history, our understanding of its persistence remains limited. Most previous studies focus primarily on slavery as a labour contract, indistinguishable from other coercive arrangements such as serfdom. More recent literature on slavery in the United States shows that enslaved people also played an important role as financial instruments. In this article,
The Iran-Israel war, launched on June 13, 2025, marked a historic intelligence failure for the Islamic Republic. Israel’s surprise offensive devastated Iran’s military leadership and exposed deep systemic flaws in its counterintelligence apparatus. The strategic collapse of the regime now raises urgent questions about its survivability and the necessity of regime change.
This case explores the interplay between commerce and colonial expansion through the lens of the Dutch East India Company (VOC) in the 17th century. Tasked with securing profit while navigating geopolitical rivalries, the VOC’s decision-makers faced dilemmas that blurred the lines between trade and conquest. This case places students in the role of the Heeren XVII, the governing board of the VOC,
BACKGROUND: Falls are common among older persons and can have a major impact on their lives. Wearable sensors used in free-living conditions (moving naturally in one's daily living environment) can be used to predict falls and fall risks. To understand if using the wearable sensors is an acceptable way for older persons to be screened for fall risks, it is important to have knowledge of older pers
