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The prognostic importance of tumor-specific nuclear insulin receptor (InsR) expression in breast cancer is unclear, while membrane and cytoplasmic localization of InsR is better characterized. The insulin signaling network is influenced by obesity and may interact with the estrogen receptor a (ERα) signaling. The purpose was to investigate the interplay between nuclear InsR, ER, body mass index (B
Background: Balancing Everyday Life (BEL), a new group-based intervention for mental health service users, was implemented in Sweden. Mental health service users often experience group interventions as meaningful, but knowledge of the process of meaning-making in a group is lacking. Aim: To explore participants’ perceptions of the group in the Balancing Everyday Life (BEL) lifestyle intervention;
Background: Reforms are changing pension systems in many European countries, in order to both restrict early retirement and force people to extend their working life. From occupational therapy and occupational science perspectives, studies focusing on aspects of working life that motivate the older worker is urgent. Aim: The aim was to describe incentives behind an extended working life among peop
Changes in chemical and physical properties resulting from water adsorption play an important role in the characterization and performance of device-relevant materials. Studies of model oxides with well-characterized surfaces can provide detailed information that is vital for a general understanding of water-oxide interactions. In this work, we study single crystals of indium oxide, the prototypic
Metal-liquid interfaces are of the utmost importance in a number of scientific areas, including electrochemistry and catalysis. However, complicated analytical methods and sample preparation are usually required to study the interfacial phenomena. We propose an infrared spectroscopic approach that enables investigating the molecular interactions at the interface, but needing only minimal or no sam
We have investigated whether alchemical free-energy perturbation calculations of relative binding energies can be sped up by simulating a truncated protein. Previous studies with spherical nonperiodic systems showed that the number of simulated atoms could be reduced by a factor of 26 without affecting the calculated binding free energies by more than 0.5 kJ/mol on average (Genheden, S.; Ryde, U.
Time-resolved photoluminescence (TRPL) measurements of nanowires (NWs) are often carried out on broken-off NWs in order to avoid the ensemble effects as well as substrate contribution. However, the development of NW-array solar cells could benefit from non-destructive optical characterization to allow faster feedback and further device processing. With this work, we show that different NW array an
In this paper, we propose a gridless method for estimating an unknown number of fundamental frequencies. Starting with a conventional dictionary matrix, containing sets of candidate fundamental frequencies and their corresponding harmonics, a non-convex log-sum cost function is formed such that it imposes the harmonic structure and treats every fundamental frequency in the dictionary as a paramete
The crowdedness of current cellular bands and the demand for higher transmission speed prompt the use of the millimeter-wave spectrum for the next-generation mobile communication. In the millimeter-wave frequencies, the dosimetric quantity for human exposure to electromagnetic fields changes from the specific absorption rate to incident power density. In this study, we used 28 GHz beam-steering pa
Shiga toxin is the main virulence factor of enterohemorrhagic Escherichia coli, a non-invasive pathogen that releases virulence factors in the intestine, causing hemorrhagic colitis and, in severe cases, hemolytic uremic syndrome (HUS). HUS manifests with acute renal failure, hemolytic anemia and thrombocytopenia. Shiga toxin induces endothelial cell damage leading to platelet deposition in thromb
The cross section of a top-quark pair produced in association with a photon is measured in proton-proton collisions at a centre-of-mass energy of s=8 TeV with 20.2 fb−1 of data collected by the ATLAS detector at the Large Hadron Collider in 2012. The measurement is performed by selecting events that contain a photon with transverse momentum pT > 15 GeV, an isolated lepton with large transverse mom
Observables sensitive to the anomalous production of events containing hadronic jets and missing momentum in the plane transverse to the proton beams at the Large Hadron Collider are presented. The observables are defined as a ratio of cross sections, for events containing jets and large missing transverse momentum to events containing jets and a pair of charged leptons from the decay of a Z/ γ∗bo
We use two-dimensional numerical simulations to study dense suspensions of non-Brownian hard particles using the Critical Load Model (CLM) under constant confining pressures. At constant packing fraction this simple model shows shear thickening as the tangential forces get activated upon increased shear stresses. By parameterizing a simple binary system of frictional and nonfrictional particles of
Aerosol-And propane bottles for consumers, including hairspray, lubricants, etc. were tested for exposure from fire. The tested bottles had a volume between 15- 400 ml of product mixed with propane and bottles with propane only containing 0.35, 0.45, 5 and 6 kg of propane. The aerosol-And propane bottles were exposed to a heptane pool fire, corresponding to properties of common available flammable
Conventionally, radiofrequency (RF) coils used for magnetic resonance imaging (MRI) are electrically small and designed for nearfield operation. Therefore, existing antenna design techniques are mostly irrelevant for RF coils. However, the use of higher frequencies in ultrahigh field (UHF) MRI allows for antenna design techniques to be adapted to RF coil designs. This study proposes the use of p
