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Background/Aim: The TGF-β pathway can influence breast cancer progression and therapy efficacy, exhibiting both pro- and anti-tumoral effects. This study examined the impact of active TGF-β signaling on recurrence and radiotherapy (RT) benefit in early-stage breast cancer, using nuclear phosphorylated Smad2 (pSMAD2) as a marker for pathway activation. Methods: Tissue-microarrays from 1178 stage I-
The article analyses strategies developed by Ukrainians who arrived in France since 2022 and who have to deal with the difficult real estate market trying to find a place to live. Going beyond the structuralist framework, the authors investigate subjective motivations and attitudes that combine with structural factors to produce different strategies of adaptation to the French housing market. Thes
Background: Management of severe aortic stenosis (AS) has evolved over the past decade, driven by the widespread adoption of transcatheter aortic valve implantation (TAVI). This study aims to assess trends in procedural volumes, patient characteristics, and outcomes for patients undergoing TAVI or surgical aortic valve replacement (SAVR) in Sweden. Methods: This was a descriptive, non-comparative,
The 2024 Lund University Conference on Teaching and Learning, hosted by MedCUL and the Division for Higher Education Development (AHU), took place in the newly inaugurated Forum Medicum – an environment purposefully designed to inspire connection, collaboration, and exchange. The venue’s open architecture mirrored the conference theme, Connecting teachers – changing from within, underscoring the r
A major reason for the great interest in regional industrial path development (RIPD) is the associated hopes for positive regional development outcomes. However, up to now we know surprisingly little about the often mixed economic, social and ecological effects of RIPD for regions. Existing studies on RIPD tend not to link to these outcomes. This special collection aims to improve our understandin
The chapter discusses the theoretical reorientation in economic geography over the last twenty years from a focus on structures, represented by regional innovation systems, to addressing the role of human agency in regional economic development, and reflects on what the two approaches can contribute to achieving sustainable regional restructuring. We are doing this by focusing on two articles – pu
The many challenges of our time call for changes in regional economies, increasingly motivating scholars to dive deep into the mechanisms and possibilities for delivering such change. However, the link between regional change and people’s well-being has often been neglected, assuming that new job opportunities, green industrial path development, or higher-value economic activities are inherently g
This article presents and discusses results from an exercise in comparative content analysis of news articles about issues of conflict produced by Afghan journalists before and after participating in an internationally sponsored training and mentorship programme in Peace Journalism. The programme was part of a Preventing Violent Extremism (PVE) project, intended to create community resources for r
This study investigates how national policies in nine Western Pacific countries—China, Japan, South Korea, Australia, New Zealand, Singapore, Malaysia, Vietnam, and Cambodia—promote healthy ageing through multi-sector collaboration. The objective is to identify common patterns and country-specific features in the governance and organization of collaborative efforts. Using comparative case study an
Some get lost in translation; Barbara Czarniawska was at home in it. Early in my career, she helped me translate my vague sense that organizational performances were stories into the more precise concept of narratives which, allowed me to connect organizational studies with literary theory. Through her teaching, notably her course <em>From Field to Desk</em>, she guided
Corrosion of cables can result in brittle and unexpected failures and represents a critical concern for prestressed concrete bridges with post-tensioned (PT) tendons. In these structures, corrosion is typically facilitated by inadequate grout injection and/or the use of poor-quality mortar during construction. Such deficiencies create favorable conditions for corrosion initiation and propagation.
This paper reflects on the challenges and opportunities of academic freedom monitoring from an advocacy perspective. Based on the review of two existing academic freedom indexes and the author's experience building scientific freedom indicators, the paper discusses three challenges: conceptual, methodological, and political. The conceptual challenges are of four kinds: undertheorization, complexit
In the Swedish context, ‘intergenerational Collaborative Housing’ and ‘Collaborative Housing for the second half of life’ (CH2L), based on the self-work model, were developed in the 1980s and 1990s. The chapter examines how ageing individuals developed caring practices and mutual support strategies in these collective housing forms and how such practices were adapted during the COVID-19 pandemic.
A search for heavy right-handed Majorana neutrinos is performed with the ATLAS detector at the CERN Large Hadron Collider, using the (Formula Presented) of proton-proton collision data at (Formula Presented) collected during Run 2. This search targets (Formula Presented) production, in which both top quarks decay into a bottom quark and a (Formula Presented) boson, where one of the (Formula Presen
High-energy nuclear collisions create a quark-gluon plasma, whose initial condition and subsequent expansion vary from event to event, impacting the distribution of the eventwise average transverse momentum [(Formula presented)]. Disentangling the contributions from fluctuations in the nuclear overlap size (geometrical component) and other sources at a fixed size (intrinsic component) remains a ch
Measurements of (anti)deuteron and (anti)He3 production in the rapidity range |y|
Current and projected environmental changes are complex and unprecedented in the context of modern societies. Effective adaptation strategies must consider constraining and enabling factors from both physical and societal aspects, as well as associated uncertainties at different points in time. Here we present a multidisciplinary method to quantify the solution space for individual adaptation meas
