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Background: Few studies have investigated the 24-hour symptom profile in patients with COPD or how symptoms during the 24-hour day are inter-related. This observational study assessed the prevalence, severity and relationship between night-time, early morning and daytime COPD symptoms and explored the relationship between 24-hour symptoms and other patient-reported outcomes. Methods: The study enr

The frictional behavior of a number of conventional tool materials used in the sheet forming industry has been studied by a recently developed tribotester based on flat-die strip drawing. The main objective was to study the frictional performance of the materials and correlate the tribological behavior mainly to the microstructure. Tooling materials tested ranged from powder metallurgical tool ste

The tensile and scaffolding properties of skin rely on the complex extracellular matrix (ECM) that surrounds cells, vasculature, nerves, and adnexus structures and supports the epidermis. In the skin, collagen I fibrils are the major structural component of the dermal ECM, decorated by proteoglycans and by fibril-associated collagens with interrupted triple helices such as collagens XII and XIV. H

The motivation of this study is the general lack of knowledge regarding the efficiency and the appropriate use of the adaptation strengths of Siemens automatic exposure control system CARE Dose 4D. The purpose was to evaluate the effect on radiation absorbed dose using different adaptation strengths of CARE Dose 4D in three routine pediatric CT protocols. A pediatric anthropomorphic whole body pha

A large ensemble of regional climate model projections was investigated regarding if and when they show an emergence of significant climate change signals in seasonal temperature and precipitation within Europe. The influence of the North Atlantic Oscillation (NAO), as simulated in the projections, was investigated. In most parts of Europe, the projections indicate robust emergence of temperature

We investigate the growth and the physical and optical properties of type-II heterostructured ZnTe/ZnSe colloidal nanocrystals, focusing on the role of the 7% lattice mismatch between the two materials in determining growth homogeneity and band structure. We find that the lattice mismatch between the two materials places limitations on the range of structures that can be grown, and for those in wh

It is known that overweight is associated with chronic knee pain (CKP) and chronic low back pain (CLBP). Several risk factors for these conditions have been postulated, including age, sex, overweight, occupation, and socioeconomic factors. In addition, physical environment has been studied as a potential risk factor in recent years. However, the associations of overweight and physical environment

PURPOSE OF REVIEW: Adaptive immune responses have been shown to play an important role in the atherosclerotic disease process and both pathogenic and protective immunity has been identified. Apolipoprotein (apo) B100 appears to be a key antigen and novel therapies modulating immune responses against apo B100 have shown promising results in experimental models. This review will discuss recent deve

The need to make consumption patterns more sustainable is widely acknowledged, yet effective policies for sustainable consumption are lacking. This article examines Nordic policy makers' views on why sustainable consumption research is difficult to apply in policy practice. We draw on the knowledge brokering literature to outline how the challenges of knowledge utilization in policy are connected

Current developments in genetics and genomics entail a number of changes and challenges for society as new knowledge and technology become common in the clinical setting and in society at large. The relationship between genetics and ethics has been much discussed during the last decade, while the relationship between genetics and the political arena-with terms such as rights, distribution, experti

The CD24 glycoprotein is a mediator of neuronal proliferation, differentiation and immune suppression in the normal CNS, and a proposed cancer biomarker in multiple peripheral tumor types. We performed a comparative analysis of CD24 gene expression in a large cohort of pediatric and adult brain tumors (n = 813), and further characterized protein expression in tissue sections (n = 39), primary brai

Single-beam side-scan sonar elements, to be fitted on a miniaturized submersible, are here simulated, manufactured, and evaluated. Finite element analysis simulations are compared with measurements, and an overall observation is that the agreement between simulations and measurements deviates from the measured values of 1.5 to 2 degrees, for the narrow lobe angle, by less than 10% for most models.

Most previous genetic epidemiology studies within the field of osteoporosis have focused on the genetics of the complex trait areal bone mineral density (aBMD), not being able to differentiate genetic determinants of cortical volumetric BMD (vBMD), trabecular vBMD, and bone microstructural traits. The objective of this study was to separately identify genetic determinants of these bone traits as a

Deoxyribonucleoside kinases phosphorylate deoxyribonucleosides into the corresponding 5'-monophosphate deoxyribonucleosides to supply the cell with nucleic acid precursors. In mitochondrial fractions of the model plant Arabidopsis thaliana, we detected deoxyadenosine and thymidine kinase activities, while the cytosol fraction contained six-fold lower activity and chloroplasts contained no measurab

Through the Clean Development Mechanism (CDM) of the Kyoto Protocol, a developed country actor with a binding emission reduction target can use emission reductions from a project implemented in a developing country to meet this target. At the same time, CDM projects are meant to contribute to sustainable development in the host country, as defined by this country. The CDM is often taken to illustr