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BACKGROUND: Long QT syndrome (LQTS) is a rare genetic disorder and a major preventable cause of sudden cardiac death in the young. A causal rare genetic variant with large effect size is identified in up to 80% of probands (genotype positive) and cascade family screening shows incomplete penetrance of genetic variants. Furthermore, a proportion of cases meeting diagnostic criteria for LQTS remain

Patients with insulin resistance have high risk of cardiovascular disease such as myocardial infarction (MI). However, it is not known whether MI can initiate or aggravate insulin resistance. We observed that patients with ST-elevation MI and mice with MI had de novo hyperglycemia and features of insulin resistance, respectively. In mouse models of both myocardial and skeletal muscle injury, we ob

Inclusive ψ(2S) production is measured in p-Pb collisions at the centre-of-mass energy per nucleon-nucleon pair sNN = 8.16 TeV, using the ALICE detector at the CERN LHC. The production of ψ(2S) is studied at forward (2.03 < ycms< 3.53) and backward (−4.46 < ycms< −2.96) centre-of-mass rapidity and for transverse momentum pT< 12 GeV/c via the decay to muon pairs. In this paper, we report the integr

Cross sections for the coherent photoproduction of ρ0 vector mesons in ultra-peripheral Pb-Pb collisions at sNN = 5.02 TeV are reported. The measurements, which rely on the π+π− decay channel, are presented in three regions of rapidity covering the range |y| < 0.8. For each rapidity interval, cross sections are shown for different nuclear-breakup classes defined according to the presence of neutro

Rituals are customarily muted into predictable routines aimed to stabilise social orders and limit conflict. As a result, their magic lure recedes into the background, and the unexpected and disruptive elements are downplayed. Our collaborative contribution counters this move by foregrounding rituals of world politics as social practices with notable disordering effects. We engage a series of ‘wor

A search for dijet resonances in events with at least one isolated charged lepon is performed using 139 fb−1 of s = 13 TeV proton-proton collision data recorded by the ATLAS detector at the LHC. The dijet invariant-mass (mjj) distribution constructed from events with at least one isolated electron or muon is searched in the region 0.22 < mjj< 6.3 TeV for excesses above a smoothly falling backgroun

It is often claimed that in Christian tradition trees and plants are reduced to passive material created for human exploitation, that the only important living creatures are Adam and Eve. But could such a view have less to do with Christianity as a religion and more to do with Cartesian notions in Western modernity? Earlier Christians undoubtedly exhibited a fascination with trees that exceeded a

Disease outbreaks and pandemics have long played a role in societal and economic change. However, the nature of such change is selective, meaning that it is sometimes minimal and, at other times, and change or transformation may be unexpected, potentially even reinforcing contemporary paradigms. A comprehensive overview of pandemics and their effects is provided. This is used to help contextualise

Ancient organic remains are essential for the reconstruction of past human lifeways and environments but are only preserved under particular conditions. Recent findings indicate that such conditions are becoming rarer and that archaeological sites with previously good preservation, are deteriorating. To investigate this, we returned to the well-known Swedish Mesolithic site Ageröd I. Here we prese

Biosynthesis of chlorophyll involves several enzymatic reactions of which many are shared with the heme biosynthesis pathway. Magnesium chelatase is the first specific enzyme in the chlorophyll pathway. It catalyzes the formation of Mg-protoporphyrin IX from the insertion of Mg2+ into protoporphyrin IX. The enzyme consists of three subunits encoded by three genes. The three genes are named Xantha-

In children with single ventricle physiology, increased pulmonary vascular resistance may impede surgical progression or result in failing single ventricle physiology. The use of pulmonary vasodilators has been suggested as a potential therapy. However, knowledge on indication, dosage, and effect is limited. A retrospective case notes review of all (n = 36) children with single ventricle physiolog

Most previous studies about fertility knowledge and attitudes among men have been based on quantitative methods using questionnaires with fixed-choice response options. The aims of this qualitative study were to explore childless young men’s reflections on fertility and infertility through semi-structured interviews. Danish (n = 17) and Swedish (n = 12) young childless men aged between 20 and 30 y