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Recent protein design experiments have demonstrated that proteins can migrate between folds through the accumulation of substitution mutations without visiting disordered or nonfunctional points in sequence space. To explore the biophysical mechanism underlying such transitions we use a three-letter continuous protein model with seven atoms per amino acid to provide realistic sequence-structure an
We have previously shown that SRp55 inhibits splicing from HIV-1 exon 3, thereby generating partially spliced mRNAs encoding HIV-1 vpr. Here we show that SRp55 also inhibits splicing from HIV-1 exon 5 to generate HIV-1 vpu/env mRNA, albeit with lower efficiency. We also show that inhibition of HIV-1 splicing by SRp55 causes the appearance of partially spliced vpu, env and vpr mRNAs in the cytoplas
In this special issue of the Journal of Environment and Development, we present results from the research project Globalisation Informed by Sustainable Development (GLOBIS), 2009-2014, funded by the European Union Framework Programme 7. Starting from and focusing on international policies on agriculture, energy, innovation, migration, and transport at both European Union and global levels, the dua
We measure elastomechanical spectra for a family of thin shells. We show that these spectra can be described by a "semiclassical'' trace formula comprising periodic orbits on geodesics, with the periods of these orbits consistent with those extracted from experiment. The influence of periodic orbits on spectra in the case of two-dimensional curved geometries is thereby demonstrated, where the para
Background Hemiarthroplasties are performed in great numbers worldwide but are seldom registered on a national basis. Our aim was to identify risk factors for reoperation after fracture-related hemiarthroplasty in Norway and Sweden. Material and methods A common dataset was created based on the Norwegian Hip Fracture Register and the Swedish Hip Arthroplasty Register. 33,205 hip fractures in indiv
Abstract in UndeterminedTheoretically, there are several reasons to expect education to have a positive effect on health. Empirical research suggests that education can be an important health determinant. However, it has not yet been established whether education and health are indeed causally related, and the effects found in previous studies may be partially attributable to methodological weakne
We present extensions to the agent-based agricultural policy simulator (AgriPoliS) model that make it possible to simulate the consequences of agricultural policy reform on farmers' land use decisions and concomitant impacts on landscape mosaic, biodiversity and ecosystem services in a real agricultural region. An observed population of farms is modelled as a multi-agent system where individual fa
Aims: Studies to show impairments in the pelvic floor extracellular matrix (ECM) associated with stress urinary incontinence (SUI) has earlier been performed, but the results are contradictory. Collagen I and III, the elastin associated proteins fibrillin-1 and fibulin-5 and the small leucine-rich repeat proteoglycans (SLRPs) decorin, lumican and fibromodulin are involved in giving the tissue its
The effects of a truly uncertain future are more far-reaching than what has traditionally been assumed in transaction cost economics. Uncertain governance choices require that agents exercise judgment in the absence of other means of estimating the payoffs associated with complex combinations of transaction attributes, contractual contingencies, and governance structures. Judgments are made on an
Socioeconomic status could potentially impact on which type of rheumatic diagnosis a patient receives. We determined whether different socioeconomic status is a risk factor for being diagnosed with spondyloarthritis (SpA) or chronic pain. In a nested case-control study, we identified two sets of adult cases diagnosed with (i) SpA (n = 1,194) and (ii) chronic pain (n = 3,730) during 2010-2012 in Sk
Scholars have argued that we have compelling reasons to combat climate change because it threatens human rights, referred to here as ‘climate rights’. The prospects of climate rights are analysed assuming two basic desiderata: its accuracy in capturing the normative dimension of climate change (reasons to prevent/mitigate/adapt to climate change); and its ability to generate political measures. In
The aim of this review is to describe imaging techniques for evaluation of non-osteochondral structures such as the synovium, menisci in the knee, labrum in the hip, ligaments and muscles and to review the literature from recent clinical and epidemiological studies of OA.
Measurement noise can generate undesired control activity resulting in wear of actuators and reduced performance. The effects of measurement noise can be alleviated by filtering the measurement signal.The design of the filter is then a trade-off; heavy filtering reduces the undesired control activity but performance is degraded. In this paper we discuss the trade-offs for PID control. Based on the
We study the light scattering properties of double layer gratings (DLGs) made from Au on SiO2 substrates. It is found that surface plasmon polaritons (SPPs) can be excited in the DLGs for a separation of up to 150 nm between the two Au grating layers and the collective reflectance spectra exhibit a strong resonant peak and a closely lying dip as a result of the surface plasmon polariton excitation
Social structures and socioeconomic patterns are the major determinants of population health. However, very few previous studies have simultaneously analysed the "social" and the "economic" indicators when addressing social determinants of health. We focus on the relevance of economic and social capital as health determinants by analysing various indicators. The aim of this paper was to analyse in
Primary objective: The aim of this study was to describe how persons with acquired brain injury experience an out-patient group rehabilitation programme and how the programme had contributed to their everyday lives. Design and method: Qualitative interviews with 11 men and women with an acquired brain injury who had participated in an out-patient group rehabilitation programme were performed. Data
It is commonly believed that higher order smoothness should be modeled using higher order interactions. For example, 2nd order derivatives for deformable (active) contours are represented by triple cliques. Similarly, the 2nd order regularization methods in stereo predominantly use MRF models with scalar (1D) disparity labels and triple clique interactions. In this paper we advocate a largely over
