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After many years of preclinical development, cell and gene therapies have advanced from research tools in the lab to clinical-grade products for patients, and today they constitute more than a quarter of all new Phase I clinical trials for Parkinson's disease. Whereas efficacy has been convincingly proven for many of these products in preclinical models, the field is now entering a new phase where

Under 1980-talet började flera svenska kommuner etablera en sekundär bostadsmarknad, där socialtjänsten hyrde ut lägenheter i andra hand till hemlösa klienter som var utestängda från den ordinarie bostadsmarknaden. Orsaken var en kombination av fastighetsägares ”höga trösklar”, socialtjänstens behov av boenden för hemlösa klienter och båda parters strävan efter kontroll. Möjligheten att tilldelas

Objectives: Christmas holidays have been associated with the highest incidence of myocardial infarction (MI). We wanted to assess possible triggers of MI during Christmas. Design: A nationwide, retrospective postal survey with case-control design. All individuals suffering an MI during the Christmas holidays 2018 and 2019 in Sweden were identified through the SWEDEHEART registry and a control grou

Denna studie är en bred genomlysning av socionomfältets dimensioneringsaspekter utifrån ett sammanhållet perspektiv där arbetsmarknadsutsikter, utbildningsfrågor och kompetensfrågor belyses dels var för sig men måste också relateras till varandra. Lärosätenas dimensionering av såväl grundutbildning som vidareutbildning måste ses i relation till arbetsmarknadens föränderliga behov av högskoleutbild

Background: Vaccine effectiveness against COVID-19 needs to be assessed in diverse real-world population settings. Methods: A cohort study of 805,741 residents in Skåne county, Southern Sweden, aged 18–64 years, of whom 26,587 received at least one dose of the BNT162b2 vaccine. Incidence rates of COVID-19 were estimated in sex- and age-adjusted analysis and stratified in two-week periods with subs

An apparently novel human plasma and urinary protein of low molecular weight was isolated from several highly purified preparations of protein HC by gel chromatography and high voltage electrophoresis with a yield of about 8 mg/g. The protein has a molecular weight of about 20,000, neutral electrophoretic mobility at pH 6.5 and a high content of half-cystine. It is associated with a yellow-brown c

gamma-Trace, a microprotein occurring in neuroendocrine cells, was demonstrated by immunohistochemical technique to be present in the calcitonin-producing C-cells of normal simian thyroid gland and of human medullary thyroid carcinoma. A comparatively high concentration of gamma-trace was demonstrated in tissue extract of neoplastic C-cells. The immunoreactive protein found in the extract had a mo

The complete amino acid sequence of the single polypeptide chain of human complex-forming glycoprotein heterogeneous in charge (protein HC) isolated from a single individual is reported with the supporting data. The primary structure was determined by automatic degradation of the intact chain and of fragments obtained by chemical and enzymatic degradations of the native or reduced and S-carboxymet

This paper investigates sustainability in retailing based on three different perspectives: i) the overall corporate management, ii) the development of an attractive product range, iii) the daily in-store management and activities. The purpose is to identify a set of main themes for each perspective, investigate contradictions and areas of conflict, and discuss how to bridge the perspectives. A qua

The cutting edge geometry has a significant influence on thermal-mechanical loads and the quality of machined surface in machining operations. In this study, a joint numerical and experimental investigation was conducted to study the effects of tool edge radius on process variables (tool temperatures, force components, stresses) and process dynamics in orthogonal machining Inconel 718. The numeric

Many research studies have been done to investigate different aspects of environmental challenges. In the product development context, there have been attempts to reduce the environmental impacts of associated activities including the production processes themselves. As a result, various technological improvements have been made and new production processes e.g. powder metallurgy technologies have

The automotive industry has striven for fuel economy and resource efficiency through the deployment of powder metallurgy (PM) manufacturing processes for few decades. However, PM technology for transmission gears is currently only used at a small scale within the automotive industry. This is mainly due to: its shortcomings in material properties and performance gaps for final parts; lack of advanc

Several parameters and variables affect the production cost and the company competitiveness. The manufacturing part cost is directly influenced by factors related to tools, workpiece materials, equipment, personnel, automation, etc. These factors also have a significant influence on the manufacturing efficiency and performance. The presented model determines the production performance with respectSeveral parameters and variables affect the production cost and the company competitiveness. The manufacturing part cost is directly influenced by factors related to tools, workpiece materials, equipment, personnel, automation, etc. These factors also have a significant influence on the manufacturing efficiency and performance. The presented model determines the production performance with respect

The aim of this work is to perform molecular dynamic simulations of nanometric cutting on single crystal copper with a diamond tool in orderto investigate the dependence of crystallographic orientation and cutting speeds on the cutting forces, machined surface and temperature. It wasfound that the temperature in the substrate, locally and globally, increased for increasing velocity. A higher degre

When small and hollow components are being manufactured, it is not uncommon that a majority of the workpiece material is removed by machining. A demand for parts made with lead-free brass alloys can potentially increase the manufacturing cost and therefore it is necessary to investigate ways to increase the material utilization. As part of a more resource efficient production, a method for reusing

Aims: To analyse dosimetric and clinical predictors for acute and late gastrointestinal toxicity following chemoradiotherapy of anal cancer. Materials and methods: Consecutive patients with locally advanced (T2 ≥4 cm – T4 or N+) anal cancer were selected from an institutional database (n = 114). All received intensity-modulated radiotherapy with concomitant 5-fluorouracil and mitomycin C. Gastroin

This paper investigates the differences of leaded and low-lead brasses in terms of mechanical and thermal properties, machinability and product strength using physical testing and simulations. The information can be used in companies for Design for Manufacturability (DFM) while designing processes for lead free brass. The novelty of this research is to combine data from different testing methods t