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Characterisation of Grains and Flour Fractions from Field Grown Transgenic Oil-Accumulating Wheat Expressing Oat WRI1

Wheat (Triticum aestivum L.) is one of the major staple crops in the world and is used to prepare a range of foods. The development of new varieties with wider variation in grain composition could broaden their use. We characterized grains and flours from oil-accumulating transgenic wheat expressing the oat (Avena sativa L.) endosperm WRINKLED1 (AsWRI1) grown under field conditions. Lipid and star

Sex differences in neuropsychiatric symptoms in Alzheimer’s disease dementia : a meta-analysis

Background: Neuropsychiatric symptoms (NPS) are common in individuals with Alzheimer’s disease (AD) dementia, but substantial heterogeneity exists in the manifestation of NPS. Sex differences may explain this clinical variability. We aimed to investigate the sex differences in the prevalence and severity of NPS in AD dementia. Methods: Literature searches were conducted in Embase, MEDLINE/PubMed,

Chasing PtOx species in ceria supported platinum during CO oxidation extinction with correlative operando spectroscopic techniques

Industrially relevant, highly dispersed, Pt/ceria and reference Pt/alumina catalysts with narrow Pt particle size distributions have been prepared, characterised ex situ and studied for CO oxidation by operando infrared and X-ray absorption spectroscopy. At high CO conversions, spectator CO ad-species on ionic platinum are observed while the CO oxidation proceeds on Pt particles in a high oxidatio

Radon metrology for use in climate change observation and radiation protection at the environmental level

Radon (222Rn) gas is the largest source of public exposure to naturally occurring radioactivity and the identification of radon priority areas is required by the Council Directive 2013/59/Euratom. Radon is also used as a tracer to improve atmospheric transport models and to indirectly estimate greenhouse gas (GHG) fluxes using the Radon Tracer Method (RTM). This method is based on the correlation

Lipid bilayer composition as a determinant of cancer cell sensitivity to tumoricidal protein-lipid complexes

Complexes formed by the alpha1 N-terminal peptide of alpha-lactalbumin and oleic acid (alpha1-oleate) interact with lipid bilayers. Plasma membrane perturbations trigger tumor cell death but normal differentiated cells are more resistant, and their plasma membranes are less strongly affected. This study examined membrane lipid composition as a determinant of tumor cell reactivity. Bladder cancer t

Importance of resting heart rate

Resting heart rate is a determinant of cardiac output and physiological homeostasis. Although a simple, but critical, parameter, this vital sign predicts adverse outcomes, including mortality, and development of diseases in otherwise normal and healthy individuals. Temporal changes in heart rate can have valuable predictive capabilities. Heart rate can reflect disease severity in patients with var

Relationship between somatostatin receptor expressing tumour volume and health-related quality of life in patients with metastatic GEP-NET

For patients with gastroenteropancreatic neuroendocrine tumours (GEP-NET), health-related quality of life (HRQoL) is important. Meanwhile, whether tumour volume is associated with HRQoL is unknown. Hence, the aim of this study was to assess if total somatostatin receptor expressing tumour volume is correlated with HRQoL in patients with metastatic GEP-NET. Some 71 patients were included in the stu

Phase II trial demonstrates the efficacy and safety of individualized, dosimetry-based 177Lu-DOTATATE treatment of NET patients

Purpose: Radionuclide therapy with 177Lu-DOTATATE is well established for patients with advanced somatostatin receptor–positive neuroendocrine tumors with a standard schedule of 7.4 GBq at four occasions. However, this approach does not consider individual variability affecting the tumor radiation dose or dose to organs at risk. Therefore, it is important to assess more personalized strategies. Th

Linking innovations and patents - a machine learning assisted method

This paper describes the methodology behind the matching of patents and a literature-based innovation output indicator (LBIO) collected from trade journals covering the manufacturing and ICT service sectors in Sweden 1970-2015. A combination of manual processing and simple machine learning tools has enabled the identification, classification and linking of patents that otherwise would have been ve

Performance and wear mechanisms of different PcBN tools when machining superalloy AD730

Nickel-based superalloys are known to be difficult to machine. These alloys are generally machined with cemented carbide tools under low productivity process conditions. Superhard polycrystalline cubic boron nitride (PcBN) tooling offers the possibility of increased production rates, however, a thorough understanding of the material performance and degradation is required before a transition from

Multicomponent binders for PcBN performance enhancement in cutting tool applications

This study proposes a novel design of binders for polycrystalline cubic boron nitride (PcBN) cutting tool materials. Well-known binder phases TiC and TiN were combined with transitional metal nitrides ZrN, VN, and HfN. Performance screenings of longitudinal turning Inconel 718 and AISI 316 L highlighted the superior performance of PcBN materials with mixed TiC-ZrN and TiC-VN binders. These two sys

European Stroke Organisation guidelines on treatment of patients with intracranial atherosclerotic disease

The aim of the present European Stroke Organisation guideline is to provide clinically useful evidence-basedrecommendations on the management of patients with intracranial atherosclerotic disease (ICAD). The guidelines wereprepared following the Standard Operational Procedure of the European Stroke Organisation guidelines and accordingto GRADE methodology. ICAD represents a major cause of ischemic

Geometry-Based Clustering Characteristics for Outdoor Measurements at 28-30 GHz

This paper presents an analysis of channel characteristics for an outdoor scenario at the frequency band of 28-30 GHz. A geometry-based clustering algorithm is proposed to group the measured multipath components (MPCs) based on the interaction points on the surrounding walls or objects obtained from Ray Tracing 3-D simulations, which is more physically interpretable than the traditional clustering

Harmonic structure, a promising microstructure design

The harmonic structure is a recently introduced concept paving the way for engineering metallic materials to achieve excellent mechanical performance. They consist of soft coarse-grained regions (Core) that are three-dimensionally surrounded by a connected network of hard ultra-fine grained regions (Shell). The interaction in these Core–Shell regions produces a synergistic effect, during plastic d

A Study Protocol for Validation and Implementation of Whole-Genome and -Transcriptome Sequencing as a Comprehensive Precision Diagnostic Test in Acute Leukemias

Background: Whole-genome sequencing (WGS) and whole-transcriptome sequencing (WTS), with the ability to provide comprehensive genomic information, have become the focal point of research interest as novel techniques that can support precision diagnostics in routine clinical care of patients with various cancer types, including hematological malignancies. This national multi-center study, led by Ge

Introduction to Preschool During the Covid-19-Pandemic: Impacts of Social Restrictions on Staff-Family Relational Establishment

The social restrictions during the covid-19 pandemic have challenged many aspects of preschool everyday life. Particularly vulnerable to these restrictions is the aspect of introducing new children to preschool, since preschool introduction constitutes a natural arena for establishment of preschool staff’s relationships with children and their parents. Organizing the preschool introduction to enab

School Psychologists’ Assessment of the Use of Psychological Knowledge in Schools: Development of the Use of Psychological Constructs in Schools

Teaching and learning could be guided by psychological knowledge to a larger extent. The aims of this study were to examine school psychologists’ (N = 117) assessments of how psychological constructs related to learning are being used by teachers in Swedish schools. In addition, we aimed to evaluate school psychologists’ awareness of teachers’ implementation of psychological knowledge. A theoretic