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Emotion regulation individual therapy for adolescents with nonsuicidal self-injury disorder : A feasibility study

Background: Nonsuicidal self-injury (NSSI) is a serious health risk behavior that forms the basis of a tentative diagnosis in DSM-5, NSSI Disorder (NSSID). To date, established treatments specific to NSSI or NSSID are scarce. As a first step in evaluating the feasibility, acceptability, and utility of a novel treatment for adolescents with NSSID, we conducted an open trial of emotion regulation in

Composite biomaterial as a carrier for bone-Active substances for metaphyseal tibial bone defect reconstruction in rats

Restoring lost bone is a major challenge in orthopedic surgery. Currently available treatment strategies have shortcomings, such as risk of infection, nonunion, and excessive resorption. Our primary aim was to study if a commercially available gentamicin-containing composite calcium sulfate/hydroxyapatite biomaterial (GBM) could serve as a carrier for local delivery of bone morphogenic protein-2 (

Assessing the GeneRead SNP panel for analysis of low-template and PCR-inhibitory samples

Massive parallel sequencing (MPS) is increasingly used for human identification purposes in forensic DNA laboratories. Forensic DNA samples are by nature heterogeneous and of varying quality, both concerning DNA integrity and matrices, creating a need for assays that can handle low amounts of DNA as well as impurities. Commercial short tandem repeat (STR) analysis kits for capillary electrophoresi

Real-life clinical outcomes with everolimus eluting platinum chromium stent with an abluminal biodegradable polymer in patients from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR)

Background: No previous studies have evaluated the performance of the Synergy stent in a large real-life population. Objectives: To describe the initial real-life experience with a novel everolimus eluting platinum chromium stent with abluminal biodegradable polymer (SYNERGY) in unselected patients from a nationwide registry. Methods: All implanted Synergy stents were compared with other new gener

Political Power of Photography: The Materiality of 14 and 6 October

This paper presents a study of the role that photography of 14 October 1973 and 6 October 1976 has played in political mobilization around the two events. It is well known that in official archives limited versions of the events can be found. We must turn to alternative repositories (private homes, non­states organisations, but also universities and libraries outside of Thailand) to find the antic

Europe's lost forests : A pollen-based synthesis for the last 11,000 years

8000 years ago, prior to Neolithic agriculture, Europe was mostly a wooded continent. Since then, its forest cover has been progressively fragmented, so that today it covers less than half of Europe's land area, in many cases having been cleared to make way for fields and pasture-land. Establishing the origin of Europe's current, more open land-cover mosaic requires a long-term perspective, for wh

Astrocytic and neuronal oxidative metabolism are coupled to the rate of glutamate–glutamine cycle in the tree shrew visual cortex

Astrocytes play an important role in glutamatergic neurotransmission, namely by clearing synaptic glutamate and converting it into glutamine that is transferred back to neurons. The rate of this glutamate–glutamine cycle (VNT) has been proposed to couple to that of glucose utilization and of neuronal tricarboxylic acid (TCA) cycle. In this study, we tested the hypothesis that glutamatergic neurotr

A field guide for cancer diagnostics using cell-free DNA : From principles to practice and clinical applications

Recently, many genome-wide profiling studies provided insights into the molecular make-up of major cancer types. The deeper understanding of these genetic alterations and their functional consequences led to the discovery of novel therapeutic opportunities improving clinical management of cancer patients. While tissue-based molecular patient stratification is the gold standard for precision medici

A multi-level model correlation approach for low-frequency vibration transmission in wood structures

The main challenge in predicting structure-borne sound in wood buildings is to accurately model the vibration transmission between the source and the receiving room. Large variations in model parameters make it difficult to predict absolute vibration levels and to make conclusions regarding the relative effects of different designs. A step towards establishing reliable models is to investigate the

Constraining the magnitude of the Chiral Magnetic Effect with Event Shape Engineering in Pb–Pb collisions at sNN=2.76 TeV

In ultrarelativistic heavy-ion collisions, the event-by-event variation of the elliptic flow v2 reflects fluctuations in the shape of the initial state of the system. This allows to select events with the same centrality but different initial geometry. This selection technique, Event Shape Engineering, has been used in the analysis of charge-dependent two- and three-particle correlations in Pb–Pb

Refined control of cell stemness allowed animal evolution in the oxic realm

Animal diversification on Earth has long been presumed to be associated with the increasing extent of oxic niches. Here, we challenge that view. We start with the fact that hypoxia (<1-3% O2) maintains cellular immaturity (stemness), whereas adult stem cells continuously - and paradoxically - regenerate animal tissue in oxygenated settings. Novel insights from tumour biology illuminate how cell st

Degradation of Ge subcells by thermal load during the growth of multijunction solar cells

Germanium solar cells are used as bottom subcells in many multijunction solar cell designs. The question remains whether the thermal load originated by the growth of the upper layers of the multijunction solar cell structure affects the Ge subcell performance. Here, we report and analyze the performance degradation of the Ge subcell due to such thermal load in lattice-matched GaInP/Ga(In)As/Ge tri

A gradient-enhanced damage model coupled to plasticity—multi-surface formulation and algorithmic concepts

A non-local gradient-enhanced damage-plasticity formulation is proposed, which prevents the loss of well-posedness of the governing field equations in the post-critical damage regime. The non-locality of the formulation then manifests itself in terms of a non-local free energy contribution that penalizes the occurrence of damage gradients. A second penalty term is introduced to force the global da