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Aim: Pseudomyxoma peritonei (PMP) is a rare disease characterized by the abundance of mucus in the abdomen without extra-peritoneal growth. Methods: Our patients with PMP have been treated with cytoreduction and hyperthermic intraperitoneal chemotherapy since 1996. The clinical and histopathological features of PMP and the relation of these features with disease-free interval and survival were ass

Aortic stenosis (AS) stands as the most common valvular heart disease in developed countries and is characterized by progressive narrowing of the aortic valve orifice resulting in elevated transvalvular flow resistance, left ventricular hypertrophy, and progressive increased risk of heart failure and sudden death. This narrative review explores clinical challenges and evolving perspectives in mode

The human brain performs tasks with an outstanding energy efficiency, i.e., with approximately 20 Watts. The state-of-the-art Artificial/Deep Neural Networks (ANN/DNN), on the other hand, have recently been shown to consume massive amounts of energy. The training of these ANNs/DNNs is done almost exclusively based on the back-propagation algorithm, which is known to be biologically implausible. Th

BackgroundTo improve future mobile health (mHealth) interventions in resource-limited settings, knowledge of participants’ adherence to interactive interventions is needed, but previous studies are limited. We aimed to investigate how women in prevention of mother-to-child transmission of HIV (PMTCT) care in Kenya used, adhered to, and evaluated an interactive text-messaging intervention.MethodsWeBackground: To improve future mobile health (mHealth) interventions in resource-limited settings, knowledge of participants’ adherence to interactive interventions is needed, but previous studies are limited. We aimed to investigate how women in prevention of mother-to-child transmission of HIV (PMTCT) care in Kenya used, adhered to, and evaluated an interactive text-messaging intervention. Method

Background: This study assessed the cost-effectiveness of proton beam therapy (PBT) compared to conventional radiotherapy (CRT) for treating patients with brain tumors in Sweden. Methods: Data from a longitudinal non-randomized study performed between 2015 and 2020 was used, and included adult patients with brain tumors, followed during treatment and through a one-year follow-up. Clinical and demo

OBJECTIVE: The late revelation of ovarian cancer ensures it as the leading cause of death among gynecologic cancers. Cytoreductive surgery (CRS) and intravenous (i.v.) chemotherapy have been the cornerstone for a long time to treat this disease. More recently, the modality of intraperitoneal administration of chemotherapy under hyperthermic conditions (HIPEC) has been added. This review surveys th

Introduction Simulation-based studies indicate that crisis checklist use improves management of patients with critical conditions in the emergency department (ED). An interview-based study suggests that use of an emergency manual (EM) - a collection of crisis checklists - improves management of clinical perioperative crises. There is a need for in-depth prospective studies of EM use during clinica

This paper investigates the aeroacoustic properties of dual-stream co-axial supersonic jets, focusing on sound generation at the engine nozzle exit, which significantly contributes to cabin noise in supersonic civil aviation. The study delves into three primary noise-generating mechanisms present in supersonic jets: broadband shock-associated noise, jet screech, and turbulent mixing noise. While s

Objective In patients with Crohn’s disease (CD) on combination therapy (infliximab and immunosuppressant) and stopping infliximab (cohort from the study of infliximab diSconTinuation in CrOhn’s disease patients in stable Remission on combined therapy with Immunosuppressors (STORI)), the risk of short-term (≤6 months) and mid/long-term relapse (>6 months) was associated with distinct blood protein

The complexity of the geometric and electronic structure of boron allotropes is associated with the multicentric bonding character and the consequent B polymorphism. When growth is limited to two-dimensions (2D), the structural and electronic confinement yields the borophenes family, where the interaction with the templating substrate actually determines the stability of inequivalent boron phases.

To clarify whether orthostatic blood pressure is affected by the type of diabetes, cardiac autonomic neuropathy, and the duration of diabetes, orthostatic blood pressure (passive 90°tilt) was evaluated in 102 patients with insulin dependent diabetes mellitus (IDDM), 51 patients with non-insulin dependent diabetes mellitus (NIDDM), and in 238 control subjects in a first study followed up after 8 to

Non-invasive characterization of brain structure has been made possible by the introduction of magnetic resonance imaging (MRI). Graph modeling of structural connectivity has been useful, but is often limited to defining nodes as regions from a brain atlas. Here, we propose two methods for encoding structural connectivity in a huge brain graph at the voxel-level resolution (i.e., 850'000 voxels) b

Bull fertility is an important trait in breeding as the semen of one bull can, potentially, be used to perform thousands of inseminations. The high number of inseminations needed to obtain reliable measures from Non-Return Rates to oestrus creates difficulties in assessing fertility accurately. Improving molecular knowledge of seminal properties may provide ways to facilitate selection of bulls wi

The efficacy and side effects of endocrine therapy in breast cancer (BC) depend largely on estrogen receptor alpha (ERα) expression, the specific drug administered, and treatment scheduling. Although the benefits of endocrine therapy outweigh any adverse effects in the initial stages of BC, later- or advanced-stage tumors acquire resistance to treatments. The mechanisms underlying tumor resistance

Plasmonic materials have optical cross sections that exceed by 10-fold their geometric sizes, making them uniquely suitable to convert light into electrical charges. Harvesting plasmon-generated hot carriers is of interest for the broad fields of photovoltaics and photocatalysis; however, their direct utilization is limited by their ultrafast thermalization in metals. To prolong the lifetime of ho

Climate change substantially affects plant phenology, resulting in earlier vegetation onset across temperate and boreal regions. Phenological shifts caused by warming may alter species interactions across trophic levels because of species-specific responses, and influence the reproductive success of dioecious species if the phenological sensitivity to warming (ST) differs between genders. We used

The aim of the present European Stroke Organisation guideline is to provide clinically useful evidence-basedrecommendations on the management of patients with intracranial atherosclerotic disease (ICAD). The guidelines wereprepared following the Standard Operational Procedure of the European Stroke Organisation guidelines and accordingto GRADE methodology. ICAD represents a major cause of ischemic

Renal cell carcinoma (RCC) is a tumour type with an indolent growth pattern and rather vague symptoms. The present study developed a platform for liquid biopsy of RCC based upon the isolation of circulating tumour cells (CTCs). Founded on the observation that RCC tumour cells are considerably larger than leucocytes, the present study employed a microfluidics-based system for isolation of RCC CTCs

Acute coronary syndrome (ACS), including acute myocardial infarction (AMI), are a leading cause ofmorbidity and mortality worldwide. Accurate risk evaluation in patients presenting with chest pain isessential for optimizing emergency department (ED) resource allocation and patient outcomes. Currentclinical decision support tools rely on structured risk scores and biomarker measurements, such as hi

Abstract in French:Le système éducatif suédois met, depuis des décennies, l’accent sur l’importance de l’évaluation critique de l’information. Néanmoins, les approches d’évaluation de l’information mises en œuvre demeurent insuffisamment développées d’un point de vue analytique. Cet article porte sur deux défis essentiels auxquels sont confrontés les établissements scolaires pour préparer les jeunTeachers are now encouraged to use generative artificial intelligence (GenAI) tools to complete various school-related administrative tasks, with the promise of saving considerable amounts of time and effort. Drawing on interviews from 57 teachers across eight schools in Sweden and Australia, this paper explores teachers’ experiences when working with GenAI. In particular, it focuses on the large