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Constraining N2O emissions since 1940 using firn air isotope measurements in both hemispheres

N2O is currently the third most important anthropogenic greenhouse gas in terms of radiative forcing and its atmospheric mole fraction is rising steadily. To quantify the growth rate and its causes over the past decades, we performed a multi-site reconstruction of the atmospheric N2O mole fraction and isotopic composition using new and previously published firn air data collected from Greenland an

Identification of opposites and intermediates by eye and by hand

In this eye-tracking and drawing study, we investigate the perceptual grounding of different types of spatial dimensions such as DENSE–SPARSE and TOP–BOTTOM, focusing both on the participants’ experiences of the opposite regions, e.g., O1: DENSE; O2: SPARSE, and the region that is experienced as intermediate, e.g., INT: NEITHER DENSE NOR SPARSE. Six spatial dimensions expected to have three differ

Outcome of peripheral T-cell lymphoma in first complete remission : a Danish-Swedish population-based study

In the present study, we investigate the outcome of 109 Danish and 123 Swedish patients with nodal PTCL in first complete remission (CR), and examine the impact of imaging-based follow-up (FU) strategies. The patients were selected by the following criteria: (a) newly diagnosed nodal PTCL from 2007 to 2012, (b) age ≥18 years, and (c) CR after CHOP or CHOEP therapy. FU guidelines in Sweden included

Actors, Institutions and Frames in Global Energy Politics

The global political economy of energy is marked by a fragmentation of actors, institutions and frames. The goal of this chapter is to map and critically interpret this fragmented landscape of energy governance. First, it provides a deconstruction of the global energy challenge, arguing that the world does not face a singular energy problem but in fact multiple energy-related challenges. Which ene

Multicomponent Moraxella catarrhalis outer membrane vesicles induce an inflammatory response and are internalized by human epithelial cells.

Moraxella catarrhalis is an emerging human respiratory pathogen in patients with chronic obstructive pulmonary disease (COPD) and in children with acute otitis media. The specific secretion machinery known as outer membrane vesicles (OMVs) is a mechanism by which Gram-negative pathogens interact with host cells during infection. We identified 57 proteins in M. catarrhalis OMVs using a proteomics a

Long-term kidney transplant outcomes in primary glomerulonephritis : Analysis from the ERA-EDTA registry

Background.We evaluated the 15-year kidney allograft survival in patients with primary glomerulonephritis and determined if the risk of graft loss varied with donor source within each glomerulonephritis group. Methods. Using data from the European Renal Association-European Dialysis and Transplant Association Registry, Kaplan-Meier, competing risk, and Cox regression analyses were performed on adu

Mirror, peephole and video - The role of contiguity in children's perception of reference in iconic signs

The present study looked at the extent to which 2-year-old children benefited from information conveyed by viewing a hiding event through an opening in a cardboard screen, seeing it as live video, as pre-recorded video, or by way of a mirror. Being encouraged to find the hidden object by selecting one out of two cups, the children successfully picked the baited cup significantly more often when th

Population of lead isotopes in binary reactions using a Rb 94 radioactive beam

We measured absolute cross sections for neutron transfer channels populated in the Rb94+Pb208 binary reaction. Cross sections have been extracted identifying directly the lead isotopes with the high efficiency MINIBALL γ-ray array coupled to a particle detector combined with a radioactive Rb94 beam delivered at Elab=6.2 MeV/nucleon by the HIE-ISOLDE facility. We observed sizable cross sections in

Exponential resolution lower bounds for weak pigeonhole principle and perfect matching formulas over sparse graphs

We show exponential lower bounds on resolution proof length for pigeonhole principle (PHP) formulas and perfect matching formulas over highly unbalanced, sparse expander graphs, thus answering the challenge to establish strong lower bounds in the regime between balanced constant-degree expanders as in [Ben-Sasson and Wigderson'01] and highly unbalanced, dense graphs as in [Raz'04] and [Razborov'03

Peptide YY (1–36) peptides from phylogenetically ancient fish targeting mammalian neuropeptide Y1 receptors demonstrate potent effects on pancreatic β-cell function, growth and survival

Aim: To investigate the antidiabetic efficacy of enzymatically stable Peptide YY (PYY) peptides from phylogenetically ancient fish. Materials and methods: N-terminally stabilized, PYY (1–36) sequences from Amia calva (bowfin), Oncorhynchus mykiss (trout), Petromyzon marinus (sea lamprey) and Scaphirhynchus albus (sturgeon), were synthesized, and both biological actions and antidiabetic therapeutic

Change in mitral regurgitation severity impacts survival after transcatheter aortic valve replacement

Background: The impact of a change in mitral regurgitation (MR) following TAVR is unknown. We studied the impact of baseline MR and early post-procedural change in MR on survival following TAVR. Methods: The SWEDEHEART registry included all TAVRs performed in Sweden. Patients were dichotomized into no/mild and moderate/severe MR groups. Vital status, echocardiographic data at baseline and within 7

Priors and Posteriors in Bayesian Timing of Divergence Analyses : The Age of Butterflies Revisited

The need for robust estimates of times of divergence is essential for downstream analyses, yet assessing this robustness is still rare. We generated a time-calibrated genus-level phylogeny of butterflies (Papilionoidea), including 994 taxa, up to 10 gene fragments and an unprecedented set of 12 fossils and 10 host-plant node calibration points. We compared marginal priors and posterior distributio

Time-space complexity and the opening hours of commerce : A study of four European cities

The aim of this article is to develop the concept of time-space complexity as a way of discussing how territorial time-space production affects urban life and use. The discussion is based on a comparative study of opening hours in four centrally located European retail areas: Angers, Lisbon, Malmö and Porto. Following a comparative study of these areas, we discuss tendencies of temporal and spatia

Simplicity at the cost of predictive accuracy in diffuse large B-cell lymphoma : A critical assessment of the R-IPI, IPI, and NCCN-IPI

The international prognostic index (IPI) and similar models form the cornerstone of clinical assessment in newly diagnosed diffuse large B-cell lymphoma (DLBCL). While being simple and convenient to use, their inadequate use of the available clinical data is a major weakness. In this study, we compared performance of the International Prognostic Index (IPI) and its variations (R-IPI and NCCN-IPI)