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Lack of Opsonic Antibody Responses to Invasive Infections With Streptococcus dysgalactiae

Introduction: Streptococcus dysgalactiae can cause severe recurrent infections. This study aimed to investigate antibody responses following S. dysgalactiae bacteraemia and possible development of protective immunity. Materials and Methods: Patients with S. dysgalactiae bacteraemia in the county of Skåne between 2017 and 2018 were prospectively included. Acute and convalescent sera were obtained.

The role of business angels in the new financial landscape

Both access to and use of external sources of finance by entrepreneurial ventures have transformed significantly over the past 10-15 years, which may have induced an important shift in the role of business angels (BAs). In this chapter we elaborate on this changing role of BAs, and in particular on the value creation provided by BAs in the new financial landscape. We propose to reframe the discuss

Comparisons of historical Dutch commons inform about the long-term dynamics of social-ecological systems

Human societies and natural ecosystems are under threat by growing populations, overexploitation of natural resources and climate change. This calls for more sustainable utilization of resources based on past experiences and insights from many different disciplines. Interdisciplinary approaches to studies of historical commons have potential to identify drivers of change and keys to success in the

Clinical records after asynchronous and synchronous e-learning courses : a multi-method randomised controlled trial on students' performance and experience

BACKGROUND: Clinical Record (CR) writing is a fundamental skill for healthcare professionals, but the best e-learning methods for teaching it remain unstudied. Therefore, we investigated speech therapy students' differences in the quality production of CR at the placement and their experience after following asynchronous or synchronous e-learning courses.METHODS: A multi-method randomised controll

Graphs with many edge-colorings such that complete graphs are rainbow

We consider a version of the Erdős–Rothschild problem for families of graph patterns. For any fixed k≥3, let r0(k) be the largest integer such that the following holds for all 2≤r≤r0(k) and all sufficiently large n: The Turán graph Tk−1(n) is the unique n-vertex graph G with the maximum number of r-edge-colorings such that the edge set of any copy of Kk in G is rainbow. We use the regularity lemma

The male bias can be attenuated in reading : on the resolution of anaphoric expressions following gender-fair forms

Despite the increased use of different types of gender-fair forms in French, studies investigating their interpretation in context remain few. To fill this gap, we conducted a pre-registered study using a timed sentence evaluation task to examine speakers' possibilities to establish an anaphoric relationship between a gendered anaphoric expression (women or men) and non-stereotyped role nouns as a

Opening Pandora's box : Reducing global circulation model uncertainty in Australian simulations of the carbon cycle

Climate projections from global circulation models (GCMs), part of the Coupled Model Intercomparison Project 6 (CMIP6), are often employed to study the impact of future climate on ecosystems. However, especially at regional scales, climate projections display large biases in key forcing variables such as temperature and precipitation. These biases have been identified as a major source of uncertai

Caring feminist states? Paternalistic feminist foreign policies and the silencing of Indigenous justice claims in Sweden and Canada

The self-identification of Sweden and Canada as exceptionally caring and ethical states committed to the goal of global gender justice has been reinforced through their adoption of feminist foreign policies (FFPs). However, despite the enthusiasm surrounding the potential of feminism as an ethical approach to foreign policy making, critics have drawn attention to the many failings of FFPs that ham

Continued Stabilization of a Cementless 3D-Printed Total Knee Arthroplasty : Five-Year Results of a Randomized Controlled Trial Using Radiostereometric Analysis

BACKGROUND: Three-dimensional (3D) printing of highly porous orthopaedic implants aims to promote better osseointegration, thus preventing aseptic loosening. However, short-term radiostereometric analysis (RSA) after total knee arthroplasty (TKA) has shown higher initial migration of cementless 3D-printed tibial components compared with their cemented counterparts. Therefore, critical evaluation o

Anorectal malformations

Anorectal malformations (ARM) are rare congenital anomalies with an overall prevalence of 3.32 per 10,000 pregnancies. ARM describe a spectrum of anomalies of the anus and rectum ranging from a minimally displaced anal canal to a complete fusion of the anorectum, vagina and urethra with hypoplastic sphincter and pelvic floor muscle. Aberrant septation of the hindgut with anomalous cloacal membrane

Crystallization of sodium sulfate in two-dimensional interconnected pore system : Insights into localized, transient, and anisotropic stress generation and material deterioration

Crystallization-induced stress within confined spaces of porous materials presents significant challenges across various disciplines, including conservation science, geomorphology, geotechnical engineering, and concrete durability. Despite its significance, understanding how localized, transient, and anisotropic stress is generated in pores due to salt crystallization, along with its mechanisms of

Timing and type of breast reconstruction in SweBRO 3 : long-term outcomes

Background: Breast reconstruction after mastectomy helps women with breast cancer feel better about their bodies and lives. There is debate about the best time and type of reconstruction (immediate versus delayed, and using own tissue versus implants). Long-term studies are rare. Aim: This study looked at long-term results of different breast reconstruction methods and timings in Swedish women who

A clinically annotated post-mortem approach to study multi-organ somatic mutational clonality in normal tissues

Recent research on normal human tissues identified omnipresent clones of cells, driven by somatic mutations known to be responsible for carcinogenesis (e.g., in TP53 or NOTCH1). These new insights are fundamentally changing current tumor evolution models, with broad oncological implications. Most studies are based on surgical remnant tissues, which are not available for many organs and rarely in a

Proteoglycans from chick limb bud chondrocyte cultures. Keratan sulfate and oligosaccharides which contain mannose and sialic acid

The precursors, [ 35S]sulfate and [2- 3H]mannose, were used to study the biosynthesis of keratan sulfate and other oligosaccharides on proteoglycans isolated from Day 8 cultures of chick limb bud chondrocytes. After alkaline borohydride treatment, three fractions with sialic acid were separated by molecular sieve chromatography. The first contained keratan sulfate which was purified by digestion w

Simulating surface soil moisture on sandy beaches

A model that simulates surface moisture content on sandy beaches for aeolian transport applications is developed and integrated into the aeolian transport model AeoLiS. The moisture content of a thin surface layer (≈2 mm thickness) is computed as a function of wave runup, precipitation, evaporation, percolation, and capillary rise from the groundwater table. The groundwater table is simulated usin

Cs3Cu4In2Cl13 Nanocrystals : A Perovskite-Related Structure with Inorganic Clusters at A Sites

An effort to synthesize the Cu(I) variant of a lead-free double perovskite isostructural with Cs2AgInCl6 resulted in the formation of Cs3Cu4In2Cl13 nanocrystals with an unusual structure, as revealed by single-nanocrystal three-dimensional electron diffraction. These nanocrystals adopt a A2BX6 structure (K2PtCl6 type, termed vacancy ordered perovskite) with tetrahedrally coordinated Cu(I) ions. In

Evacuation behaviors and emergency communications : An analysis of real-world incident videos

Emergencies such as fires and terrorist attacks pose risks of injuries and fatalities, which can be exacerbated by delayed, ill-informed, or unmanaged responses. Effective emergency communication strategies could be used to better inform people and reduce these risks. This research analyzes videos of real-world emergencies to: (a) identify people's observed behaviors that increase risk during evac