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There is a need of problematizing taken for granted assumptions in the conceptualization of collaborative housing when attempting to link collaborative housing and social integration. What are the difficulties and opportunities that migrants and non-migrants face in accessing collaborative housing projects? Addressing such type of questions will help to capture exclusionary processes affecting old

Background: Emergency surgery for acute type A aortic dissection in patients with previous cardiac surgery is controversial. This study aimed to evaluate the association between previous cardiac surgery and outcomes after surgery for acute type A aortic dissection, to appreciate whether emergency surgery can be offered with acceptable risks. Methods: All patients operated on for acute type A aorti

AIMS: Cellular communication network factor 2 (CCN2) is a matricellular protein implicated in fibrotic diseases, with ongoing clinical trials evaluating anti-CCN2-based therapies. By uncovering CCN2 as abundantly expressed in non-diseased artery tissue, this study aimed to investigate the hypothesis that CCN2 plays a pivotal role in maintaining smooth muscle cell (SMC) phenotype and protection aga

There is no answer to the question “Are sustainability challenges solvable within capitalism?” which is not already taking sides in a debate about values, perceptions and motivations. There are several different approaches to sustainability, based on assumed feasibilities and expected agents of change. By disclosing one’s own stand in the debate while being aware and acknowledging other possible a

The cycle of waterborne methylmercury (meHg) in Little Rock Lake is characterized by a period of accumulation during summertime (when the lake is warm and open to the atmosphere) and a period of decline during winter (when the lake is scaled by ice). We followed this cycle for 16 yr. during which time the lake was acidified with H,SO., and then allowed to recover naturally as part of a long-term f

Popular Abstract in Swedish Cancer är en komplex och heterogen sjukdom där celler har börjat växa okontrollerat och denna sjukdom är idag ett stort hälsoproblem. På grund av diffusa symptom upptäcks cancern ofta i ett sent stadium. Otillräcklig kunskap om olika fenotyper hindrar utvecklingen av riktad behandling och patienter svarar därför väldigt olika på en given behandling. Denna avhandling ärCancer is a complex and heterogeneous disease where cells have started to grow uncontrolled and this disease remains a major health problem. Because of diffuse symptoms it often presents at a late stage. Insufficient understanding of the different phenotypes hinders the development of targeted therapeutics and consequently patients show a diverse range of responses to a given treatment. This thes

Behörighetsgivande högskolepedagogisk utbildning har nu blivit verklighet runt om i landet. Det finns från flera håll en stark förhoppning om att sådan utbildning ska bidra till att undervisningen utvecklas. Samtidigt kostar dessa kurser både pengar och tid, något som kanske går ut över andra utvecklingsinitiativ. Det är därför extra viktigt att ha ett utvecklingsperspektiv vid planering och genom

The aim of this thesis was to study the chemical communication involved in aggressive and reproductive behaviours in the European lobster (Homarus gammarus). Both male and female H. gammarus established and maintained dominance, but the sexes used different strategies for dominance maintenance. Male losers recognised individual fight opponents and avoided them but fought actively against unfamili

"It is not the eyes that fool you, it’s not the ears that can’t hear It’s the darling conceptions of your time that makes you feel this way" Detta sjunger 1600-talsastronomen Galileo Galilei i en av FRAMTIDSBOKENS artiklar, och alla sex ingående artiklar kretsar kring konceptuella problem knutna till vår tid och ett samhälle som är mer och mer uppkopplat. Dessa dilemman är såväl juridiska som tan

Kinins are potent pro-inflammatory peptides that act through two G protein-coupled receptor subtypes, B1 (B1R) and B2 (B2R). Kinin-stimulated B2R signaling is often transient, whereas B1R signaling is sustained. This was confirmed by monitoring agonist-stimulated intracellular Ca(2+) mobilization in A10 smooth muscle cells expressing human wild-type B2R and B1R. We further studied the role of rece

Essential hypertension is a multifactorial disorder and is the main risk factor for renal and cardiovascular complications. The research on the genetics of hypertension has been frustrated by the small predictive value of the discovered genetic variants. The HYPERGENES Project investigated associations between genetic variants and essential hypertension pursuing a 2-stage study by recruiting cases

The archaeological site of Fracción Mujular is composed of several small residential plaza groups and a monumental ballcourt located near the Pacific Coast of Chiapas, Mexico. Long known for the Central Mexican iconography found on its carved stelae (Navarrete 1976, 1986; García-Des Lauriers 2005, 2007, 2016; Taube 2000), the survey and excavations conducted during the course of this dissertation

Neurofibrillary tangle (NFT) pathology in the medial temporal lobe (MTL) is closely linked to neurodegeneration, and is the early pathological change associated with Alzheimer’s Disease (AD). In this work, we investigate the relationship between MTL morphometry features derived from high-resolution ex vivo imaging and histology-based measures of NFT pathology using a topological unfolding framewor

Normal differentiation and induced reprogramming require the activation of target cell programs and silencing of donor cell programs. In reprogramming, the same factors are often used to reprogram many different donor cell types. As most developmental repressors, such as RE1-silencing transcription factor (REST) and Groucho (also known as TLE), are considered lineage-specific repressors, it remain

The science of decision making is studied in many areas of science and engineering, for example within, computer science, automatic control theory, mathematics and neurophysiology. The aim of this text is to provide a very brief overview of some of the models and tools used within mathematical decision making. These models can be studied in terms of an agent that observes the world and takes decisThe science of decision making is studied in many areas of science and engineering, for example within, computer science, automatic control theory, mathematics and neurophysiology. The aim of this text is to provide a very brief overview of some of the models and tools used within mathematical decision making. These models can be studied in terms of an agent that observes the world and takes decis

Background: Most patients with Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies do not carry mutations in known disease-causing genes. The aim of this study was to identify a novel gene implicated in the development of these disorders. Methods: Our study was done in three stages. First, we did genome-wide linkage analysis of an Italian family with dominantly inherit

Background: Calcium overload is a major cause of reperfusion myocardial injury. Multidetector computed tomography (MDCT) has been previously used in visualizing coronary artery calcium, but not calcium deposits in reperfused infarction. Purpose: To assess the ability of MDCT to 1) noninvasively visualize and characterize calcium deposits in reperfused infarcts, and 2) monitor regional wall swellin