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Purpose: To study the phenotype in two families with genetically identified autosomal dominant retinitis pigmentosa (adRP) focusing on macular structure and function. Methods: Clinical data were collected at the Department of Ophthalmology, Lund University, Sweden, for affected and unaffected family members from two pedigrees with adRP. Examinations included optical coherence tomography (OCT), ful

Müllerian mimicry among Neotropical Heliconiini butterflies is an excellent example of natural selection, associated with the diversification of a large continental-scale radiation. Some of the processes driving the evolution of mimicry rings are likely to generate incongruent phylogenetic signals across the assemblage, and thus pose a challenge for systematics. We use a data set of 22 mitochondri

Background: GEOMAGIA50.v3 is a comprehensive online database providing access to published paleomagnetic, rock magnetic, and chronological data from a variety of materials that record Earth's magnetic field over the past 50 ka. Findings: Since its original release in 2006, the structure and function of the database have been updated and a significant number of data have been added. Notable modific

Popular Abstract in Swedish Denna studie har gått ut på att relatera litogeo- kemin (= kemin i bergarter) kring Stollbergs järn- och sulfidmalmsfält i Bergslagen till mineralogi och geologisk utveckling. Bergarterna kring Stollberg, liksom kring nästan alla andra järn- och sulfidmalmer (Cu, Pb, Zn) i Bergslagen, utgörs av vulkaniska bildningar. De vulkaniska bergarterna och tillhörande malmer bilThe Paleoproterozoic Fe-Pb-Zn-Mn(-Ag) Stollberg deposit is situated in the Bergslagen region of south-central Sweden. 6.65 Mt of sphalerite, galena and manganiferous skarn magnetite ore occur as disseminations and semi-massive to massive ore bodies hosted by volcanogenic sediments and carbonate rocks. Field relations, mineralogy and geochemistry suggest that the felsic volcanic rocks at Stoll- be

Home heating transitions influence sociocultural practices and bring about structural changes in daily life. To uncover the power dynamics underpinning these transformations, this paper applies a visionary framework for feminist energy systems designed to challenge hegemonic and unsustainable energy cultures in pursuit of a more just and equitable future. Drawing on the framework's political, econ

Current models for understanding the spatial diffusion of innovation exhibit significant limitations when it comes to explaining how transformative innovations in sectors of the foundational economy travel between cities and countries. Transformative innovations in infrastructure sectors like water, energy, or waste management are typically not reducible to single products or technologies but rely

Background: Genetic variants in SEC61A1 are associated with autosomal dominant tubulointerstitial kidney disease. SEC61A1 is a translocon in the endoplasmic reticulum membrane and variants affect biosynthesis of renin and uromodulin. Methods: A patient is described that presented at 1 year of age with failure-to-thrive, kidney failure (glomerular filtration rate, GFR, 18 ml/min/1.73m2), hyperkalem

In his dissertation Blomberg (2004) investigates into how the care manager reform is incorporated into organizational practice in the care of older people in Sweden. He shows that it is made through different lines of argumentations following one another. Through applying neo-institutional theory this can be understood as “solutions seeking problems to solve” rather than the other way around. In t

Performance audit has become increasingly common in the public administration and every western democracy has today an independent National Audit Office (NAO). However, although the external requirements may be met, the functioning of these agencies may be jeopardized by internal and more subtle cultural factors relating to the role of the performance auditor. In Sweden, a new NAO called Riksrevis

Since the rise of radical geography in the early 1970s, political economy has been crucial in examining the spatial dynamics of capital in economic geography. Marxist and non-Marxist (particularly institutionalist) economic geographers use political economy to challenge non-political economy approaches that ignore the relationship between microeconomic processes and their spatial manifestations an

This thesis contributes to the development of the proposed NNBAR experiment at theEuropean Spallation Source (ESS), which aims to search for free neutron-antineutron oscillations with unprecedented experimental sensitivity. Achieving this goal requires both an intense beam of cold neutrons and a detector capable of reconstructing the pionic final state expected from antineutron annihilation on a c

Oxidative stress has been implicated as an important factor in the progression of many diseases. An imbalance in the redox-system may cause oxidation of cells and molecules, which might subsequently lead to tissue damage. The research presented in this thesis has focused on elucidating a possible involvement of the human protein alpha-1-microglobulin in the defence against pathological oxidation.

The present thesis is aimed to examine the hypothesis that the degree of vascular inflammation correlates with the expression of vascular endothelin and angiotensin receptors. The receptor changes were studied in subcutaneous resistance arteries in patients with different degrees of ischemic heart disease (IHD). In addition, patients with giant cell arteritis (GCA) were also investigated because o

What conformations do protein molecules populate in solution? Crystallography provides a high-resolution description of protein structure in the crystal environment, while NMR describes structure in solution but using less data. NMR structures display more variability, but is this because crystal contacts are absent or because of fewer data constraints? Here we report unexpected insight into this

Tadpoles from two types of ponds, temporary and permanent, were raised in a common garden experiment. There was no clear effect of pond type on development rate (time for metamorphosis). From each sibship, one group was raised under a constant water regime (deep tanks) and one was subject to simulated pond drying (shallow tanks). The tadpoles exhibited a plastic response to pond drying: they metam

Popular Abstract in Swedish I denna avhandling har jag undersökt hur man kan utöka det dynamiska omfånget utan att öka noggrannheten i en analog-till-digital omvandlare med en flyttalsliknande lösning. Den valda lösningen går ut på att man förstärker en analog insignal med flera oberoende analoga förstärkare med skilda förstärkningar. Sedan väljs den förstärkare som ger den starkaste utsignalen s

The Department of English in Lund: Working Papers in Linguistics is an annual volume produced by the English Department at Lund University in Sweden. Its main aim is to publicize research being carried out by staff and post-graduate students in the department, but we are also pleased to include contributions from members of neighbouring departments and universities. The contributions in volume 3