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Algebraic dependence of commuting elements in algebras

The aim of this paper to draw attention to several aspects of the algebraic dependence in algebras. The article starts with discussions of the algebraic dependence problem in commutative algebras. Then the Burchnall-Chaundy construction for proving algebraic dependence and obtaining the corresponding algebraic curves for commuting differential operators in the Heisenberg algebra is reviewed. Next

Automation and the nature of driving - The effect of adaptive cruise control on drivers' tactical driving decisions

Advanced driving assistance systems that offer support by operating for example longitudinal control will have an effect on the transport system. Previous studies have also shown that drivers may be slower to respond in hazardous situations with systems like adaptive cruise control (ACC) engaged, if the system suddenly fails. Little understanding has, so far, emerged to explain why. In this thesis

Simultaneous release of hydrophobic and cationic solutes from thin-film "plum-pudding" gels: A multifunctional platform for surface drug delivery?

The release of two compositionally different solutes from a composite gel composed of two different populations of microgel particles embedded in a single bulk gel matrix is described, showing the potential of the "plum-pudding gel" as a multifunctional platform for controlled surface release. One hydrophobic solute (pyrene) and one hydrophobic and charged solute (rhodamine 123) were chosen as the

Abnormal vascular network complexity: a new phenotypic marker in hereditary non-polyposis colorectal cancer syndrome

BACKGROUND: Hereditary non-polyposis colorectal cancer (HNPCC) (Lynch cancer family syndrome I (LCFS1) and II (LCFS2)) is one of the most common hereditary cancer disorders. HNPCC results from dominantly inherited germline mutations in mismatch repair (MMR) genes, leading to genomic instability and cancer. No predictive physical signs of HNPCC are available to date. AIMS: Increased complexity in t

Algebraic curves for commuting elements in the q-deformed Heisenberg algebra

In this paper we extend the eliminant construction of Burchnall and Chaundy for commuting differential operators in the Heisenberg algebra to the q-deformed Heisenberg algebra and show that it again provides annihilating curves for commuting elements, provided q satisfies a natural condition. As a side result we obtain estimates on the dimensions of the eigenspaces of elements of this algebra in i

Differentiation induced by physiological and pharmacological stimuli leads to increased antigenicity of human neuroblastoma cells

Sympathetic neuronal differentiation is associated with favorable prognosis of neuroblastoma (NB), the most common extra-cranial solid tumor of early childhood. Differentiation agents have proved useful in clinical protocols of NB treatment, but using them as a sole treatment is not sufficient to induce tumor elimination in patients. Therefore, complementary approaches, such as immunotherapy, are

ID2 expression in neuroblastoma does not correlate to MYCN levels and lacks prognostic value

The MYCN proto-oncogene is frequently amplified in a subgroup of highly aggressive neuroblastomas. The molecular mechanism(s) by which the overexpressed MYCN contributes to an aggressive tumor cell behavior is not well understood. Recently, it was reported that the ID2 gene is a direct target for the MYCN and MYC transcription factors, and that ID2 expression and MYCN amplification correlate posit

Removal of the fermentation by-product succinyl L-tyrosine from the beta-lactamase inhibitor clavulanic acid using a molecularly imprinted polymer

Clavulanic acid is a beta-lactamase inhibitor used in therapeutic combinations with the penicillin-type antibiotics. During the fermentation leading to clavulanic acid, a succinyl L-tyrosine by-product is unavoidably formed. Occasionally, the amount of this by-product is found to be as high as 2% of the product even after standard purification operations. To further remove this impurity, we prepar

Laser produced X-ray source in the 10-60 keV range at 1 kHz. Modified irradiation schemes in order to reach medical imaging quality

By tightly focusing ultra-short pulses from a Ti:sapphire terawatt laser onto a high-Z metallic target, hard x-ray pulses of short duration are produced. In most of our previous work concerning x-rays, a 150 mJ laser pulse with a 110 A duration has been used. Using mostly tin and tantalum targets, hard x-rays in the 10-60 keV range have been produced and used in differential absorption imaging aro

Nutrients and micronutrients at risk during renal replacement therapy : a scoping review

PURPOSE OF REVIEW: Malnutrition is frequent in patients with acute kidney injury. Nutrient clearance during renal replacement therapy (RRT) potentially contributes to this complication. Although losses of amino acid, trace elements and vitamins have been described, there is no clear guidance regarding the role of micronutrient supplementation. RECENT FINDINGS: A scoping review was conducted with t

Nullstellensatz Size-Degree Trade-offs from Reversible Pebbling

We establish an exactly tight relation between reversiblepebblings of graphs and Nullstellensatz refutations of pebbling formulas,showing that a graph G can be reversibly pebbled in time t and space s if and only if there is a Nullstellensatz refutation of the pebbling formulaover G in size t + 1 and degree s (independently of the field in whichthe Nullstellensatz refutation is made). We use this

Rif2 protects Rap1-depleted telomeres from MRX-mediated degradation in Saccharomyces cerevisiae

Rap1 is the main protein that binds double-stranded telomeric DNA in Saccharomyces cerevisiae. Examination of the telomere functions of Rap1 is complicated by the fact that it also acts as a transcriptional regulator of hundreds of genes and is encoded by an essential gene. In this study, we disrupt Rap1 telomere association by expressing a mutant telomerase RNA subunit (tlc1-tm) that introduces m

Late stabilization after initial migration in patients undergoing cemented total knee arthroplasty : a 5-year followup of 2 randomized controlled trials using radiostereometric analysis

BACKGROUND AND PURPOSE: In total knee arthroplasty (TKA), metal-backed (MBT) and all-polyethylene (APT) designs have shown comparable implant migration up to 2 years postoperatively using radiostereometric analysis (RSA). However, studies comparing mid-term migration of both designs are lacking. Furthermore, continuously migrating TKAs up to 2 years may continue to migrate or stabilize thereafter.

The entrepreneurial orientation in the transformation of universities

Universities are a relevant and little-explored context to the study of strategic action, considering their need to adapt to environmental dynamics and establish a closer relationship with society. This study contributes to shedding light on how the changing process from a traditional university model to a more entrepreneurial model takes place. Thus, this study aims to analyze the role played by

The Story of How Estebanico Became Mustafa in Laila Lalami’s The Moor’s Account: Retelling Stories in a Post-Colonial Light

Both post-colonialism and historical novels are highly topical research themes in today’s literary field, but storytelling as a genre has lost its status. This essay aims to look at the importance of storytelling in the 2014 published novel The Moor’s Account, and how storytelling can be connected to post-colonial rewritings of history. This is achieved through looking at the emphasis on storytell

Den yttre och inre ordningen : En analys av Gustaf Wingrens syn på kallelsen

Abstract Denna uppsats fokuserar på Gustaf Wingrens lära om kallelsen vilken har sin grund i Wingrens avhandling Luthers lära om kallelsen från 1942. Det är ett textstudium där den övergripande frågeställnigen handlar om Wingrens syn på Guds handlande med människan i den yttre ordningen och i det inre samvetet. Det jag kommer fram till är på vilket sätt Guds rike, det jordiska och himmelska riket,

Unlocking cultural heritage : a case study of metadata management at Europeana

This MA thesis introduces Europeana and information science principles to the field of museology. Its aim is to identify challenges in digital cultural heritage metadata management within an international context. To do this, this thesis focuses on specific aspects: the European Data Model, international cooperation, and the metadata management process specific to Europeana. The study is designed

A framework for implementing customer-service chatbots: The case for LUZ shopping centre in Jerez, Spain

With the advancement of artificial intelligence, customers and users in general have been more used to having a virtual assistance method for service-related tasks. However, in the shopping centre industry, the self-help solutions mostly follow the traditional pattern of having a conciérge or a totem where you can look for the location of a particular store. This thesis aims to look at this with a