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Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q < 0.05). Loci influencing fasting insulin concentration showed association with lipid levels a

Measurement of the charm and beauty structure functions using the H1 vertex detector at HERA

Inclusive charm and beauty cross sections are measured in e (-) p and e (+) p neutral current collisions at HERA in the kinematic region of photon virtuality 5a parts per thousand currency signQ (2)a parts per thousand currency sign2000 GeV2 and Bjorken scaling variable 0.0002a parts per thousand currency signxa parts per thousand currency sign0.05. The data were collected with the H1 detector in

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.

We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and 57,574 controls of European ancestry. We identified 49 distinct association signals at these loci, including five mapping in or near KCNQ1. 'Credible sets' of the variants most likely to drive each distinct signal mapped predominantly to noncoding sequence, implying that association with T2D is mediated thro

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.

The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 commo

Diffractive electroproduction of rho and phi mesons at HERA

Diffractive electroproduction of rho and phi mesons is measured at HERA with the H1 detector in the elastic and proton dissociative channels. The data correspond to an integrated luminosity of 51 pb(-1). About 10500 rho and 2000 phi events are analysed in the kinematic range of squared photon virtuality 2.5 <= Q(2) <= 60 GeV2, photon-proton centre of mass energy 35 <= W <= 180 GeV and squared four

Biological, clinical and population relevance of 95 loci for blood lipids

Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic intervention. We screened the genome for common variants associated with plasma lipids in >100,000 individuals of European ancestry. Here we report 95 signi

Radiation-hard semiconductor detectors for SuperLHC

An option of increasing the luminosity of the Large Hadron Collider (LHC) at CERN to 1035 cm-2 s-1 has been envisaged to extend the physics reach of the machine. An efficient tracking down to a few centimetres from the interaction point will be required to exploit the physics potential of the upgraded LHC. As a consequence, the semiconductor detectors close to the interaction region will receive s

Introduction

Introduction 1 PLEASURE, PREFERENCE, AND HAPPINESS: VARIATIONS ON THEMES FROM MILL Johan Brännmark Department of Philosophy, Lund University johan.brannmark@fil.lu.se ABSTRACT: Mill’s qualitative hedonism has been subject to much debate. It was formulated to strike a balance between classical hedonism and perfectionist conceptions of happiness and many have thought that either it is an abandonment

https://www.fil.lu.se/hommageawlodek/site/papper/BrannmarkJohan.pdf - 2026-05-08

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A Z A H A R M O N G E Partitioned m ethods for tim e-dependent therm al fluid-structure interaction 2018 Doctoral Theses in Mathematical Sciences 2018:5 ISBN 978-91-7753-775-5 ISSN 1404-0034 Partitioned methods for time-dependent thermal fluid-structure interaction AZAHAR MONGE Lund University Faculty of Science Centre for Mathematical Sciences Numerical Analysis – CE N T R U M S C I E N T I A R U

https://www.maths.lu.se/fileadmin/maths/Azahar_Monge_WEBB.pdf - 2026-05-05

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Master’s Dissertation Engineering Acoustics ADAM CEDERQUIST Report TV BA -5056 A D A M C ED ERQ U IST EX PER IM EN TA L IN V ESTIG A TIO N O F STR U C TU R E-B O R N E N O ISE IN D U C ED B Y R A ILW A Y TR A FFIC IN A M U LTI-STO R EY B U ILD IN G EXPERIMENTAL INVESTIGATION OF STRUCTURE-BORNE NOISE INDUCED BY RAILWAY TRAFFIC IN A MULTI- STOREY BUILDING TVBA-5056HO.indd 1TVBA-5056HO.indd 1 2018-12

https://www.akustik.lth.se/fileadmin/tekniskakustik/publications/tvba5000/webTVBA5056.pdf - 2026-05-07

Fabian.doc

Fabian.doc The syntax and pragmatics of exclamations and other expressive/emotional utterances1,2 FABIAN BEIJER 1 Introduction In the linguistic literature we find discussions and descriptions of linguistic phenomena such as EXPRESSIVE UTTERANCES, EXCLAMATORY UTTERANCES, EXPRESSIVE SENTENCES, EXCLAMATIONS, EXCLAMATIVES, and EXPRESSIVE SPEECH ACTS. Linguists have thus observed that there are emotio

https://www.sol.lu.se/fileadmin/media/forskning/workingpapers/engelska/vol02/Fabian.pdf - 2026-05-07

This is the title of my paper

This is the title of my paper Syntactic autonomy and result clauses* JONATHAN R. WHITE, HÖGSKOLAN DALARNA Abstract In this paper I look at whether the syntactic properties of the result clause construction in English can be predicted from its semantic properties. I adopt the semantics of Meier (2000, 2003) which treats the construction as having a hidden conditional meaning. The structure she prop

https://www.sol.lu.se/fileadmin/media/forskning/workingpapers/engelska/vol04/white-wp-04.pdf - 2026-05-07

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a k t u el lt o m v e t ensk a p o ch h ä l sa • n ov 20 0 6 Nya vägar för cancer- behandling November 2006 Denna tidskrift ges ut av Medicinska fakulteten vid Lunds universitet och Universitetssjukhuset i Lund & Universitetssjukhuset MAS vid Region Skåne Aktuellt om Vetenskap & hälsa a k t u el lt o m v e t ensk a p o ch h ä l sa • n ov 20 0 6 in sig på egenskaper, signaler och mekanismer som b

https://www.vetenskaphalsa.se/wp-content/uploads/2010/08/Aktuellt-om-vet-o-h%C3%A4lsa-06.pdf - 2026-05-07

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i HUMAN RIGHTS CITIES AND SDGS IN ASIA Henri Sitorus Contributors: Shin Gyonggu, Francis Perez, Sylvia Yazid, Saiju Chacko, HS Tisnanta, Unang Mulkhan The Raoul Wallenberg Institute of Human Rights and Humanitarian Law 2022 REPORT HUMAN RIGHTS CITIES AND SDGS IN ASIA Henri Sitorus Contributors: Shin Gyonggu, Francis Perez, Sylvia Yazid, Saiju Chacko, HS Tisnanta, Unang Mulkhan The Raoul Wallenberg

https://rwi.lu.se/wp-content/uploads/2024/06/HR-Cities-and-SDGs-in-Asia.pdf - 2026-05-08

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Doctoral Thesis Structural Mechanics Report TV SM -1023 YA SM EEN TA LEB O BA ID A T STR U C TU R A L R ETR O FITTIN G O F C O N C R ETE B EA M S U SIN G FR P - D eb o n d in g Issu es YASMEEN TALEB OBAIDAT STRUCTURAL RETROFITTING OF CONCRETE BEAMS USING FRP - Debonding Issues Detta är en tom sida! Department of Construction Sciences Structural Mechanics Copyright © Yasmeen Taleb Obaidat, 2011. Pr

https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm1000/web1023.pdf - 2026-05-08

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

We analysed whole-genome sequences of 560 breast cancers to advance understanding of the driver mutations conferring clonal advantage and the mutational processes generating somatic mutations. We found that 93 protein-coding cancer genes carried probable driver mutations. Some non-coding regions exhibited high mutation frequencies, but most have distinctive structural features probably causing ele

Systematic investigation of projectile fragmentation using beams of unstable B and C isotopes

Background: Models describing nuclear fragmentation and fragmentation fission deliver important input for planning nuclear physics experiments and future radioactive ion beam facilities. These models are usually benchmarked against data from stable beam experiments. In the future, two-step fragmentation reactions with exotic nuclei as stepping stones are a promising tool for reaching the most neut

A reference panel of 64,976 haplotypes for genotype imputation

We describe a reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole-genome sequence data from 20 studies of predominantly European ancestry. Using this resource leads to accurate genotype imputation at minor allele frequencies as low as 0.1% and a large increase in the number of SNPs tested in association studies, and it can help to discover and refine causal loci.

Coulomb dissociation of N 20,21

Neutron-rich light nuclei and their reactions play an important role in the creation of chemical elements. Here, data from a Coulomb dissociation experiment on N20,21 are reported. Relativistic N20,21 ions impinged on a lead target and the Coulomb dissociation cross section was determined in a kinematically complete experiment. Using the detailed balance theorem, the N19(n,γ)N20 and N20(n,γ)N21 ex