The aim of the study was to investigate, over time, the incidence of and mortality due to malignant diseases among persons with haemophilia, compared to matched controls. Persons with haemophilia A or B were enrolled via registries at each haemophilia centre, as well as from the National Patient Registry, and were compared to five sex and age-matched controls per patient. Data from the national Ca

Even more than in developing countries today, public health strategies to fight infectious disease in the past focused on the prevention of new infections by stopping their spread. These strategies were motivated by new insights into the causes of disease and the modes of transmission in the mid-nineteenth century. By combining longitudinal individual-level data on 17,000 children in a rural/semi-

OBJECTIVE: It has been proposed that remission should be maintained throughout the course of rheumatoid arthritis (RA); however, the evidence supporting this is limited. Physical function measured by the Health Assessment Questionnaire (HAQ) is a major outcome in RA, and HAQ is shown to be one of the strongest predictors of longterm outcomes. The purpose of this study was to investigate the physic

Critique of religion and its consequences is a topical theme. The attack on the satirical magazine Charlie Hebdo in Paris in January 2015 made the Western media establishment to rally in defence of freedom of expression, but it also raised the question of the limits of this freedom. There are always defined limits to freedom of expression, which change over time and are adapted to the political sy

Osteoarthritis (OA) is the most common form of arthritis and often causes pain and functional impairment. Despite its high burden on society, knowledge about the occurrence of OA and its associated mortality is sparse. The epidemiology of OA is difficult to determine due to the patients’ fluctuating symptoms and challenges in detecting and defining the radiographic disease. The specific aims of th

This paper deals with a number of aspects of intonation in spontaneous dialogues in a language technology perspective. The key topics to be addressed are: I) the analysis of global intonation and its interaction with textual structure, II) the implementation of global and textual aspects of discourse intonation in an analysis-by-synthesis environment. We present models for the analyses of intonati

OBJECTIVES: Health utilities derived from answers to generic health-related quality of life (HRQoL) questionnaires such as the EuroQol 5-Dimensions (EQ-5D) are often used in cost-utility analyses (CUAs) of new and expensive treatments. Different preference sets (tariffs) used in the computation of utility values and quality-adjusted life-years (QALYs) from questionnaire responses (health states) y

Labour management in the past has been the studied by researchers from various disciplines and perspectives. Among labour economists and economic historians, there is an emerging current that aims to test hypotheses derived from theories about internal labour markets. So far, most studies have focused on companies whose workforces have been stable or expanding over time. This paper analyzes the in

This paper studies family commitment among fast-track professionals and explores how continued childbearing and union stability vary among high-achieving men and women. The focus is on three particular fast-track professional groups (e.g., lawyers, medical doctors and Ph.D.s), that face quite different career structures and work environments that may affect family life. The determinants of having

This paper suggests an approach to conceptualize problems of unsustainability situations by embedding the Drivers-Pressure-State-Impact-Response (DPSIR) scheme within a system of jurisdictional levels represented by Torsten Hägerstrand’s system of nested domains. Taken together these frameworks offer one way to decipher complex situations at different levels by identifying specific problem areas,

This paper deals with socioeconomic differences in mortality among infants, children, adults, and elderly during the period of mortality decline in the nineteenth century. It uses multilevel Cox regression controlling for shared unobserved factors at the family level, and also compares the magnitude of the observed differences between socioeconomic groups with the impact of unobserved factors at f

Many aspects of present energy systems and the direction towards future energy systems are incompatible with sustainable development. Sustainable bioenergy systems contribute to combating climate change and improving energy security. Expanding bioenergy decreases carbon dioxide emissions if replacing fossil fuels, establishing energy crops, or integrating with carbon capture and storage, and incre