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Real-world analysis of MET exon 14 mutations in non-small cell lung cancer : a retrospective study from two Swedish hospitals

Background: Real-World evidence on mesenchymal-epithelial transition exon 14 skipping mutations (METex14) in lung cancer remains limited. With an incidence of 3–4% across histological subtypes, METex14 is now an actionable target for MET inhibitors (METi) in advanced lung cancer, demonstrating response rates between 30–70%. Yet, its role in early stages and sensitivity to immune checkpoint inhibit

Prophylactic Treatment of Children with Hemophilia in Sweden

Hemophilia A/B are caused by deficiency or lack of coagulation factors VIII (FVIII) or factor IX (FIX), respectively, in plasma. A person with hemophilia develops bleeding in the joints and muscles at an early age, which, if left untreated, leads to early arthropathy. Preventive treatment can be achieved by regular (prophylactic) administration of FVIII/FIX. In 1958, this was implemented on a smal

EQ-5D utility, response and drug survival in rheumatoid arthritis patients on biologic monotherapy : A prospective observational study of patients registered in the south Swedish SSATG registry

Objectives Biologic agents have dramatically changed treatment of rheumatoid arthritis (RA). To date only scarce head-To-head data exist especially when the biological therapies are given as monotherapy without concomitant disease modifying drugs (DMARDs). Thus the objective of the current study is to evaluate treatment response of all available biological therapies with special focus on utility (

The weapon of a new generation?—Swedish Civil Society Organizations’ use of social media to influence politics

The article examines the extent of and factors behind Civil Society Organizations’ (CSOs’) use of social media to influence politics compared with nondigital political strategies, that is, using the traditional media and demonstrations. Taking stock of previous research on information and communication technologies, social media, and political influence, the relevance of four sets of factors is te

Acrylamide in Potato Crisps - A Three-year Study on Swedish-grown Potatoes

Acrylamide, a probable human carcinogen, has been found at mg/kg levels, in heat-treated carbohydrate-rich foods. Acrylamide is formed via the Maillard reaction as a result of the reaction between the amino acid asparagine and reducing sugars (glucose and fructose). Potatoes contain relatively high levels of both asparagine and reducing sugars and therefore potato products such as crisps, French f

The Forest and the Trees: Industrialization, Demographic Change, and the Ongoing Gender Revolution in Sweden and the United States, 1870-2010

This paper examines the major trends unravelling the long-term gender division of family support and care structure that reached its peak in the middle of the twentieth century, often called the “worker-carer” or the “separate spheres” model. The unraveling of the “separate spheres” began with the increase in the labor force participation of married women and continues with the increase in men’s i