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Background: Community-acquired pneumonia (CAP) was one of the most common causes of death in the European Union in 2017. Severity and mortality of CAP increase with age and an aging European population will require increased planning for prevention, control, and management of CAP. The purpose of this study was to provide an updated population-based estimate of the incidence of CAP requiring hospit

BACKGROUND: Mental health service users often experience difficulties interpreting and regulating sensory stimuli resulting in increased anxiety, decreased abilities to engage in activities and a hampered recovery process. However, there are limited studies on the implementation of such recovery-oriented interventions targeting sensory difficulties via sensory modulation techniques. Therefore, the

Parkinson's disease (PD) is characterized by dopaminergic neurodegeneration, α-Synuclein (α-Syn) pathology, and inflammation. Microglia in the substantia nigra pars compacta (SNpc) upregulate major histocompatibility complex class II (MHCII), and variants in genes encoding MHCII affect PD risk. Additionally, elevated TNF levels and α-Syn-reactive T cells in circulation suggest a strong link betwee

Low birthweight is a risk factor for type 2 diabetes. We hypothesised that differential associations between birthweight and clinical characteristics in persons with and without type 2 diabetes may provide novel insights into the role of birthweight in type 2 diabetes and its progression. We analysed UK Biobank data from 9,442 persons with and 254,446 without type 2 diabetes. Associations between

Introduction In type 2 diabetes (T2D), beta cell failure is often associated with islet inflammation driven by the innate immune response, with macrophages playing a significant role. However, the composition and phenotype of lymphoid immune cells in the islets of individuals with T2D have not been extensively studied. This study aims to characterize and compare the presence, phenotype, and freque

TAR DNA-binding protein 43 (TDP-43) pathology is linked to the neurodegenerative disorders amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Huntington disease (HD). Dysregulation of metabolism and emotion is shared across these disorders and may be caused by hypothalamic pathology. Inclusions with TDP-43 are present in the hypothalamus in clinical ALS, as well as selective lo

Description: Early interventions with PMDs can improve the independence and developmental outcomes of children with disabilities. Increasing awareness and interdisciplinary collaboration are essential to overcome barriers to access to PMDs. Expanding global partnerships and integrating PMDs into clinical and educational settings can increase children's access to mobility. ABSTRACT: Background The Description: Early interventions with PMDs can improve the independence and developmental outcomes of children with disabilities. Increasing awareness and interdisciplinary collaboration are essential to overcome barriers to access to PMDs. Expanding global partnerships and integrating PMDs into clinical and educational settings can increase children's access to mobility. ABSTRACT: Background The

Den 31 mars 2016 trädde Arbetsmiljöverkets föreskrifter (AFS 2015:4) om organisatorisk och social arbetsmiljö (OSA) i kraft och ersatte tre andra på området gällande föreskrifter. Genom OSA förstärks och försvagas olika regleringar som gynnar arbetstagarintresset av psykisk hälsa i arbetslivet respektive arbetsgivarintresset av arbetsledningsrätt på bekostnad av varandra. Undersökningen visar at

Vad är det som skapar en tolerant människa? Vilka berättelser motiverar oss att hjälpa varandra, att skydda varandra och att sträva efter en bättre värld? Undersökningar har visat att läsning av serien om Harry Potter främjar en mer tolerant inställning till marginaliserade grupper i samhället. Uppsatsens syfte var att ta reda på vad detta beror på, genom att undersöka vilka etiska teorier respektWhat makes a human tolerant? What stories motivate us to help each other, to protect each other, and to strive for a better world? A study has shown that reading the series about Harry Potter promotes a more tolerant attitude toward groups that are marginalized in society. The purpose of this essay was to find out why that is, by investigating the ethical theories and penal theories respectively t

Antalet företagsförvärv har de senaste åren ökat och det finns indikationer på att en sådan trend kommer att fortlöpa. En annan trend på marknaden för företagsförvärv är framväxten av AI- teknologin som på olika sätt kan få konsekvenser för förvärvsprocessen. Dessa två trender i kombination med riskfördelningen mellan parterna föranleder uppsatsens syfte som är att utreda köparens undersökningspliThe amount of mergers and acquisitions has during the past years increased and there are factors that speak for such a trend to proceed. Another trend on the market for mergers and acquisitions is the emergence of AI that could contain consequences for the acquisition-process in several ways. These two trends combined with the risk-sharing between the parties give rise to the purpose of the essay

Uppsatsen undersöker hur Dublinförordningen förhåller sig till Europakonventionen, med fokus på artikel 8 om rätten till respekt för privatliv, familjeliv, hem och korrespondens. Dublinförordningen är det instrument i EU:s gemensamma asylsystem som bestämmer vilken medlemsstat som ska ansvara för att pröva en inkommen asylansökan. På senare år har mycket kritik riktats mot Dublinförordningen p.g.aThe essay examines how the Dublin Regulation relates to the European Convention on human rights, focusing on Article 8 on the right to respect for privacy, family life, home and correspondence. The Dublin Regulation is the instrument of the EU's Common Asylum System, which determines which Member State will be responsible for examining an asylum application. In recent years, much criticism has

Som följd av klimatförändringar kommer klimatanpassningsåtgärder att bli nödvändiga för att skydda mot effekterna av det förändrade klimatet. Det förändrade klimatet kommer innebära att risken för översvämningar och erosion ökar längs med Sveriges kuster, sjöar och vattendrag. Vem det är som bär ansvaret för att se till att dessa klimatanpassningsåtgärder kommer till stånd råder det en osäkerhet k

The thesis uses hermeneutical analysis as well as reception and content analysis to interpret a current architectural debate. Within the architectural profession, there is a dogmatic style standard. Since the 1930s, modernism (also known as functionalism) has been the predominating style in architecture. This has led to an open resistance to architectural modernism brought before the public and to