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Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer lacking effective drugs and therefore new treatment targets are needed. In this study, we define the role of homeobox protein B6 (HOXB6) and HOXB8 in controlling pancreatic cancer tumorigenesis and immune response. Transcriptomic analysis comparing human embryonic and PDAC tissue identified a large overlap of expression profiles suggesting

With the shift toward de-escalating surgery in breast cancer, prediction models incorporating imaging can reassess the need for surgical axillary staging. This study employed advancements in deep learning to comprehensively evaluate routine mammograms for preoperative lymph node metastasis prediction. Mammograms and clinicopathological data from 1265 cN0 T1-T2 breast cancer patients (primary surge

Aims Cardiac telerehabilitation addresses common barriers for attendance at exercise-based cardiac rehabilitation (EBCR). Pragmatic real-world studies are however lacking, limiting generalizability of available evidence. We aimed to evaluate feasibility, safety, and patient perceptions of remotely delivered EBCR in a multicentre clinical practice setting after myocardial infarction (MI). Methods a

Biphasic insulin secretion, which fails in type 2 diabetes, can be provoked by various nutrient stimuli, glucose being the superior physiological one. To identify pathways that may play a role in β-cell stimulus-secretion coupling, we compared β-cell and islet functional, secretory, and metabolic responses to glucose and 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH), a leucine analog, tha

Oxidative stress and alterations in redox signalling have been implicated in the pathophysiology of myocardial infarction (MI). NADPH oxidase (Nox) is an important source of reactive oxygen species (ROS) in the infarcted myocardium. Alarmin S100A8/A9 amplifies acute myocardial inflammation in MI and has been shown to be a promising therapeutic target to improve cardiac function post-MI. We aimed t

Background: Internet-delivered cognitive behavioural therapy (ICBT) is an effective and accessible treatment for mild to moderate depression and anxiety disorders. However, up to 50% of patients do not achieve sufficient symptom relief. Identifying patient characteristics predictive of higher post-treatment symptom severity is crucial for devising personalized interventions to avoid treatment fail

Objective. Multicentre studies in molecular radiotherapy face challenges in ensuring the comparability of dosimetry results. The aim of this study was to develop a validation protocol to achieve equivalent 177Lu-SPECT quantification across centres, consisting of a test exercise in combination with an action level. Approach. 177Lu-SPECT/CT imaging of 3D-printed kidney phantoms with non-uniform acti

Background: Individualized cancer rehabilitation should be an integral part of cancer care. Contact nurses play a key role in identifying patient needs and coordinating evidence-based interventions to support rehabilitation. However, cancer rehabilitation remains marginal in current practice, as contact nurses face challenges due to the lack of systematic processes for assessment, intervention, an

Introduction: Tumor deposits are an important negative prognostic factor for long-term oncological outcomes in colorectal cancer patients, independent of lymph node status. Several novel models have been proposed to further integrate tumor deposits into the TNM-staging system, but their comparative performance remains unclear. The aim of this study was to identify, compare and validate novel progn

Background Increased vitamin B6 catabolism related to inflammation, as measured by the PAr index (the ratio of 4-pyridoxic acid over the sum of pyridoxal and pyridoxal-5'-phosphate), has been positively associated with lung cancer risk in two prospective European studies. However, the extent to which this association translates to more diverse populations is not known. Materials and methods For th

The use of per- and polyfluoroalkyl substances (PFAS)containing aqueous film forming foams (AFFF)at fire training facilities can have an adverse impact on the surrounding environment. The aim of the present study was to study the distribution and temporal trend of 26 PFAS in water and sediment cores for a lake and a pond affected by AFFF release from a fire training facility in Luleå, northern Sw

BACKGROUND Orthostatic hypotension (OH), defined as a sustained drop in systolic or diastolic blood pressure upon standing, is known to negatively affect survival in the general population. However, its impact on outcomes in patients with advanced coronary artery disease remains unclear. The aim of this study was to assess the prevalence and prognostic value of OH in patients undergoing isolated c

Populärvetenskaplig sammanfattning: Koldioxid är en viktig växthusgas. Växthusgaser fungerar som värmeisolerare i atmosfären och höjer temperaturen på jorden så att liv blir möjligt. Koldioxid utgör även en viktig del av fotosyntesen och respirationen hos jordens organismer. Sen början av den industriella revolutionen har halten koldioxid i atmosfären ökat exponentiellt. Utnyttjandet av fossila brCarbon dioxide in the atmosphere contributes to the greenhouse effect, which is essential to life on our planet. Furthermore, it plays an important part of the photosynthesis and respiration of the world’s organisms. Since the start of the industrial revolution the amount of carbon dioxide in the atmosphere has increased exponentially. The main source is the extensive burning of fossil fuels. If t

Populärvetenskaplig sammanfattning: Övergödningen av våra kustnära hav blev akut under 1980-talet, syrefria bottnar och giftiga algblomningar visade tydligt att något var mycket fel. Kväve, ett näringsämne, visade sig vara en av huvudorsakerna till dessa reaktioner i havet. De största kvävespridarna i Sverige var jordbruk och reningsverk. Avloppsvattenhanteringen behövde förändras och ett sätt att

Populärvetenskaplig sammanfattning: Flera olika klimatsimuleringar har visat på en sannolik förändring av jordens klimat, till största delen beroende på utsläpp orsakade av mänsklig aktivitet. Eftersom klimatet påverkar såväl ekosystem som livsmiljö är det av största intresse att kartlägga vilka konsekvenser en eventuell klimatförändring kan få. Även om människans vardag för det mesta påverkas av