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BACKGROUND The nature and underlying mechanisms of an inverse association between adult height and the risk of coronary artery disease (CAD) are unclear. METHODS We used a genetic approach to investigate the association between height and CAD, using 180 height-associated genetic variants. We tested the association between a change in genetically determined height of 1 SD (6.5 cm) with the risk of

Waist circumference (WC) and waist-to-hip ratio (WHR) are surrogate measures of central adiposity that are associated with adverse cardiovascular events, type 2 diabetes and cancer independent of body mass index (BMI). WC and WHR are highly heritable with multiple susceptibility loci identified to date. We assessed the association between SNPs and BMI-adjusted WC and WHR and unadjusted WC in up to

Epidemiological studies suggest health-protective effects of flavan-3-ols and their derived compounds on chronic diseases. The present study aimed to estimate dietary flavan-3-ol, proanthocyanidin (PA) and theaflavin intakes, their food sources and potential determinants in the European Prospective Investigation into Cancer and Nutrition (EPIC) calibration cohort. Dietary data were collected using

We have previously identified Transcription Factor B1 Mitochondrial (TFB1M) as a Type 2 Diabetes (T2D) risk gene, using human and mouse genetics. To further understand the function of TFB1M and how it is associated with T2D we created a β-cell specific knockout of Tfb1 m, which gradually developed diabetes. Prior to the onset of diabetes, β-Tfb1 m(-/-) mice exhibited retarded glucose clearance due

Background: Most current knowledge on kidney concentrations of nephrotoxic metals like cadmium (Cd), mercury (Hg), or lead (Pb) comes from autopsy studies. Assessment of metal concentrations in kidney biopsies from living subjects can be combined with information about exposure sources like smoking, diet, and occupation supplied by the biopsied subjects themselves. Objectives: To determine kidney

Purpose: Cocaine-and amphetamine-regulated transcript (CART) peptide exerts several regulatory functions acting both as neurotransmitter and hormone. We recently showed that CART is expressed in various neuroendocrine tumors, including small bowel carcinoids. The main objective of the present study was to examine whether CART expression is associated with survival in patients with small bowel carc

Genome-wide association studies (GWASs) have identified many SNPs underlying variations in plasma-lipid levels. We explore whether additional loci associated with plasma-lipid phenotypes, such as high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TGs), can be identified by a dense gene-centric approach. Our meta-ana

Library 2.0 is a term which emerged a few years ago and is frequently discussed. There is no uniform definition of the term but the central aspect of the concept is to encourage increased participation from library users. The aim of this Master's thesis is to investigate if and if so, how the professional role of the librarian is affected by Library 2.0. To do that, we have conducted a case s

The purpose of this study has been to investigate how frequently, and in witch ways, theories concerning the "late-modern" society are being used in the contemporary research of social work. My thesis is that theories concerning the late-modern society could be useful in social work research, foremost to shed light on, and broaden the understanding of, dilemmas and problems that are spec

Title: The competent teacher-external and internal frameworks and their influence on educational praxis. This thesis is about what kind of approach a teacher (may) consider when he is facing parameters that he can not do anything about, in this case represented by political, educational och social frameworks. One of the things a teacher can do to adapt to the situation is to see what possibilities

The landfills located at the sea shore or below the ground water table are a severe cause of concern due to their close proximity to sensitive coastal ecosystems and pristine ground waters. Therefore, it is important to assess the long term environmental risks of coastal landfills before their final closure. In this context, the reactive transport models, by allowing us to study the complex interp

Sammanfattning Studien utredde orsaken till partnerval inom den egna etniska gruppen. Judiska universitetsstuderande (n=42) jämfördes med icke-judiska svenska universitetsstuderande (n=42) och deltagarna jämfördes på variablerna ingruppsidentitet, likhet, stöd från socialt nätverk, partnerval och kollektivism. Dessutom attraktivitetsskattades personer med och utan davidsstjärna. Bäst prediktor fö

Several of researches shows that youths seek other kinds of participatory channels for political engagements then the representative structure can give them. Citizens who participate in the political process develop an increased knowledge about the society and the more knowledge about the society the larger reason to participate. This thesis was done with the assumption that the experience of part

Title: Evaluating packaging logistics performance at IKEA for improvements in product and packaging development Authors: Håkan Dahlborg and Carina Johnsson Supervisors: Jenny Klevås ? Division of Packaging Logistics, Department of Design Sciences, Lund Institute of Technology, Lund Caroline Bramklev ? Division of Packaging Logistics, Department of Design Sciences, Lund Institute of Technolog