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Summary. Severe haemophilia and reduced bone density can negatively influence perception of patient's health-related quality of life (HRQoL), especially considering future aspects, the risk of losing independence or pain suffering. The aim of this study was to assess levels of HRQoL in severe haemophilia patients and to compare HRQoL to those of the general population as well as to determine wheth

Abstract in UndeterminedIn many industries, a national accident investigation board conducts investigations following major accidents. For safety improvements to be achieved, however, it is essential that the recommendations presented in these investigations are followed by necessary actions. In this paper, challenges related to implementation of recommendations from accident investigations are st

Objective: This report examines the foundation of β-cell failure in type 2 diabetes and suggests areas for future research on the underlying mechanisms that may lead to improved prevention and treatment. Participants: A group of experts participated in a conference on October 14-16, 2013 cosponsored by The Endocrine Society and the American Diabetes Association. A writing group prepared this summa

Aims Alternative transcription and splicing of the allograft inflammatory factor-1 (AIF-1) gene results in the expression of two different proteins: AIF-1 and interferon responsive transcript-1 (IRT-1). Here we explore the impact of AIF-1 and IRT-1 on vascular smooth muscle cell (VSMC) activation and neointima formation, the mechanisms underlying their alternative splicing, and associations of AIF

Entrepreneurship education has grown rapidly and there is a steady increase in entrepreneurship courses and programs worldwide. For the past decade, research topics in entrepreneurship education have mainly been related to the entrepreneurial intentions, actions, and learning process of students. However, not much research related to entrepreneurship educators has been conducted. Specifically, the

This master’s thesis is about public libraries and how the work they do for children and youth in the summer holidays relates to public policy and reading research. Triangulation of methods is used with literature review, policy analysis, questionnaire survey and interviews. My primary theoretical framework is Carol Bacchi’s ’What’s the problem represented to be’ (WPR) approach, which is also us

Barnadråpsbestämmelsen medför en privilegiering för det fall en kvinna uppsåtligen dödar sitt nyfödda barn. Straffet för brottet är fängelse i högst sex år. Trots att dagens reglering sällan tillämpas i praxis, har dess föregångare –barnamordsbestämmelsen– en mörk och omfattande historia, som under 1700-talet utgjorde det dominerande straffrättsliga och kriminalpolitiska problemet i samhället. SamThe infanticide provision entails a privileging of the case when a woman intentionally kills her newborn child. The range of punishment for the crime is imprisonment for a maximum of six years. Despite its rare application today, the provision has a dark and extensive history and constituted a significant challenge for criminal law and criminal policy during the 18th century. The societal view of

Betesmarker kan rädda våra pollinatörer Pollinatörer gör att vi får mat i form av frukt, grönsaker, vilda växter och frön. Det senaste århundrandet har jordbruket blivit allt mer intensivt vilket gjort att pollinatörer minskat, framförallt de med specifika karaktärsdrag. Små pollinatörer, och de som har specialiserad diet och boplats har pekats ut som särskilt utsatta för intensivt jordbruk. En aIn the last century, agricultural intensification has led to loss of permanent pastures in the landscape which has been correlated with a loss in biodiversity. Specifically, small specialist species are more negatively affected. Often because they have a higher demand on suitable complementary habitats, larger home-range requirements of a high quality. Small species also have a lower mobility and

Detta examensarbete utfördes i samarbete med Patientnämnden Skåne, som är en av Region Skånes fristående förvaltningar. Patientnämnden ansvarar bland annat för hantering av patienters klagomål om hälso- och sjukvård som tillhör Region Skåne. Att sammanfatta klagomål är en av uppgifterna inom hanteringen av klagomål. Patientnämnden står inför två utmaningar med denna uppgift. För det första är uppgThis thesis was conducted in collaboration with the Patients’ Advisory Committee, which is one of the independent administrations of Region Skåne. Patients’ Advisory Committee is responsible, among other things, for handling patient complaints regarding healthcare services belonging to Region Skåne. Summarizing complaints is one of the tasks within the complaint handling process. The Patients’ Adv

In recent years, microwave applications in the food products have attracted increasing attention by the food packaging industry and the consumers due to their convenience, low energy and water usage and short processing time giving them a sustainable advantage over competing technologies. In-pack pasteurization represents one of the fastest developing technologies in preparing and delivering safe

I Sverige finns det ungefär 22 miljoner kycklingar och höns. Den miljöpåverkan som uppkommer genom deras liv kommer främst från deras mat. För att kunna minska miljöpåverkan från kycklingarna och hönsen är det därför nödvändigt att titta närmre på hönsfoder. Genom att studera produktionskedjan för deras foder kan man upptäcka var störst miljöpåverkan uppkommer och vad man kan göra för att minska d

BACKGROUND. Recombinant human PDGF-BB (rhPDGF-BB) reduces Parkinsonian symptoms and increases dopamine transporter (DAT) binding in several animal models of Parkinson's disease (PD). Effects of rhPDGF-BB are the result of proliferation of ventricular wall progenitor cells and reversed by blocking mitosis. Based on these restorative effects, we assessed the safety and tolerability of intracerebrove

Background and purpose The Scandinavian Sarcoma Group (SSG) XIV protocol is based on experience from previous SSG trials and other osteosarcoma intergroup trials, and has been considered the best standard of care for patients with extremity localized, non-metastatic osteosarcoma. We analyzed the outcome in 63 consecutive patients. Patients and methods From 2001 through 2005, 63 patients recruited

The function of alpha-cells in patients with type 2 diabetes is often disturbed; glucagon secretion is increased at hyperglycaemia, yet fails to respond to hypoglycaemia. A crucial mechanism behind the fine-tuned release of glucagon relies in the exocytotic machinery including SNARE proteins. Here, we aimed to investigate the temporal role of syntaxin 1A and SNAP-25 in mouse alpha-cell exocytosis.