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Gestational diabetes and maternal obesity are associated with epigenome-wide methylation changes in children

Offspring of women with gestational diabetes mellitus (GDM) are at increased risk of developing metabolic disease, potentially mediated by epigenetic mechanisms. We recruited 608 GDM and 626 control offspring from the Danish National Birth Cohort, aged between 9 and 16 years. DNA methylation profiles were measured in peripheral blood of 93 GDM offspring and 95 controls using the Illumina HumanMeth

Photo-reactivity (apparent quantum yield) of dissolved organic carbon during the freshwater transit from land to sea

In spite of substantial greenhouse gas emissions from photo-degradation of dissolved organic carbon (DOC), little is known about the variability in DOC photo-reactivity. It has been suggested that photo-reactivity depends on the degree of DOC pigmentation. However, recent evidence suggests that also non-colored fractions can be photo-reactive. Furthermore photo-degradation processes interact with

In situ plankton community respiration measurements show low respiratory quotients in a eutrophic lake

Planktonic community respiration is an important carbon cycling process, typically quantified by converting measured values of dissolved oxygen consumption rates into carbondioxide production rates using a respiratory quotient of 1 (RQ = carbondioxide per oxygen by moles). However, the true variability in planktonic RQs between different aquatic ecosystems is poorly understood. We conducted in sit

Sustainability of an Enhanced Recovery Program for Pancreaticoduodenectomy with Pancreaticogastrostomy

Background: Enhanced recovery program for pancreaticoduodenectomy have become standard care. Little is known about adherence rates and sustainability of the program, especially when pancreaticogastrostomy is used in reconstruction. The aim of this study was, therefore, to evaluate adherence rates and continued outcome, after implementation of an enhanced recovery program. Methods: Consecutive pati

Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium

Macronutrient intake, the proportion of calories consumed from carbohydrate, fat, and protein, is an important risk factor for metabolic diseases with significant familial aggregation. Previous studies have identified two genetic loci for macronutrient intake, but incomplete coverage of genetic variation and modest sample sizes have hindered the discovery of additional loci. Here, we expanded the

Impact of Harvest Date and Cutting Length of Grass Ley and Whole-Crop Cereals on Methane Yield and Economic Viability as Feedstock for Biogas Vehicle Fuel Production

Grass ley and whole-crop cereals used for biogas production are often finely chopped for subsequent ensiling and anaerobic digestion. Chopping can impact not only ensiling stability, digestibility and risk of process hick-ups in the digester but also harvesting capacity and fuel consumption. Based on field experiment data, the aim of this study was to investigate how three different nominal cuttin

The cultural citizenship values of political comedy engagement

The freedom to express oneself as a citizen is paramount to contemporary democracy. However, this freedom is often questioned in relation to humour and the offence it might cause, especially in cases where humour is referred to as an excuse, as a defence to avoid criticism (Smith 2009). This article uses the concept of cultural citizenship (cf. Hermes 2005) to conceptualise citizen rights and resp

Precision medicine in Type 2 Diabetes

The Precision Medicine Initiative defines precision medicine as "an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person." This approach will facilitate more accurate treatment and prevention strategies in contrast to a one-size-fits-all approach, in which disease treatment and prevention strategi

From occupational therapy to environmental gerontology

Based on reflections on childhood experiences, my autobiography starts out from completing professional training as an occupational therapist. After academic studies in gerontology, I pursued PhD education in public health, with a specific interest in housing and health issues related to aging and disability. My early scientific work was concentrated to methodology development based on the notion

Time shift between net and gross CO2 uptake and growth derived from tree rings in pine and spruce

Key message: A 6–9 month backward time shift of the carbon uptake gave the highest correlation between annual biomass increment and carbon uptake in this old even aged forest. Abstract: Plants’ carbon uptake and allocation to different biomass compartments is an important process for both wood production and climate mitigation. Measurements of the net ecosystem carbon dioxide exchange between ecos

Improving cyanobacteria and cyanotoxin monitoring in surface waters for drinking water supply

Cyanobacteria in fresh water can cause serious threats to drinking water supplies. Managing cyanobacterial blooms particularly at small drinking water treatment plants is challenging. Because large amount of cyanobacteria may cause clogging in the treatment process and various cyanotoxins are hard to remove, while they may cause severe health problems. There is lack of instructions of what cyanoba

Group leader and participant perceptions of Balancing Everyday Life, a group-based lifestyle intervention for mental health service users

Background: There exist few recovery and occupation-based interventions for mental health service users. Balancing Everyday Life (BEL) is a new occupation-based lifestyle intervention that was created to fill this need. Aim: To gain group leaders’ and participants’ perspectives of the BEL intervention content and format, including factors that helped, hindered, and could be improved. Methods: A co

The genetic architecture of type 2 diabetes

The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of the heritability of this disease. Here, to test the hypothesis that