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Understanding the microclimate in a given site influences the preconditions of sustainable development in many ways. Cold and strong winds in the winter will, for example, intensify the energy use in buildings depending on the air tightness of the building enclosure (Bagge et al., 2011), and in areas close to the seafront strong salty winds may also increase the wear and tear on building materials
Preparing travel time data can be a time-consuming process, which greatly limits the flexibility of transport simulation models. In the current paper, we present an approach to integrate a routing engine locally in an existing modeling framework, hence enabling to dynamically calculate travel times in the constructed emergency medical services (EMS) simulation models. This integration eliminates t
A large number of cities have created semantic 3D city models, but these models are rarely used as input data for simulations, such as noise and flooding, in the urban planning process. Reasons for this are that many simulations require detailed land cover (LC) and elevation data that are often not included in the 3D city models, and that there is no linkage between the elevation and land cover da
Lately information- and communication technology (ICT) has been seen as an important tool to vitalize democracy. What kind of democracy it generates is however debateable. The objective with this thesis is therefore to examine what democratic ideal that dominates the use of ICT in Region Skåne and Västra Götalandsregionen and what kind of citizenship it brings. The two case studies were chosen bec
The purpose of this study was to examine social workers apprehensions about institutional placement of youths and what determines when these proceedings are used. When research not always shows that institutional placements lead to positive changes for youngsters, we wondered how social workers act on their assessment to institutional placement. We wanted to find out if the social workers meet any
While emotional language and imagery in protest esthetics are nothing new, emotions have been repressed in modern political discourse at large, as being seen as irrational if not dangerous. As new media platforms, such as Twitter and Facebook, are becoming central media spaces for live online broadcasting of political protests, they have become an important site of discursive struggle for research
BACKGROUND: Mental health problems are the main cause of sick leave in today's working age population. Employers are responsible for their employees' work environment and preventing work-related illnesses, but their knowledge regarding mental health problems is lacking. Employer beliefs and support strategies need further exploration. OBJECTIVE: To explore employers' beliefs, knowledge and strateg
Heart failure (HF) is a major public health problem characterized by inability of the heart to maintain sufficient output of blood. The systematic characterization of circulating proteins across different stages of HF may provide pathophysiological insights and identify therapeutic targets. Here we report application of aptamer-based proteomics to identify proteins associated with prospective HF i
The transcription factor TCF7L2 remains the most important diabetes gene identified to date and genetic risk carriers exhibit lower insulin secretion. We show that Tcf7l2 regulates the auxiliary subunit of voltage-gated Ca2+ channels, Cacna2d1 gene/α2δ-1 protein levels. Furthermore, suppression of α2δ-1 decreased voltage-gated Ca2+ currents and high glucose/depolarization-evoked Ca2+ signaling whi
