Individuals with rapidly progressing atherosclerotic plaques are at higher risk of experiencing acute complications. Currently, we lack knowledge regarding factors in human plaque that cause rapid progression. Using the 14C bomb-pulse dating method, we assessed the physical age of atherosclerotic plaques and which biological processes were associated with rapidly progressing plaques. Interestingly

Objectives: Type I interferons (IFNs) are central and reflective of disease activity in systemic lupus erythematosus (SLE). However, IFN-α levels are notoriously difficult to measure and the type I IFN gene signature (IGS) is not yet available in clinical routine. This study evaluates galectin-9 and an array of chemokines/cytokines in their potential as surrogate markers of type I IFN and/or SLE d

Autoantigen discovery is a critical challenge for the understanding and diagnosis of autoimmune diseases. While autoantibody markers in current clinical use have been identified through studies focused on individual disorders, we postulated that a reverse approach starting with a putative autoantigen to explore multiple disorders might hold promise. We here targeted the epidermal protein transglut

Cities across the world are increasingly labelling themselves as smart in one way or another. At the same time, this smartness appears amorphous or invisible in its built urban environment. Critical researchers writing on the smart city regularly express confusion or exasperation about precisely the difficulty to locate the smart in the city. Visibility of the smart city is not a given. This artic

This review presents the status and outlook for shared energy systems (SES) and fifth-generation district heating and cooling (5GDHC). It provides an overview of the technical and functional knowledge encompassing design and development, operational and system architecture, and control and decision support systems of these technologies. The review also presents different tools and models found in

BACKGROUND: Costs and a low total number of cases may be obstacles to the successful implementation of a paediatric robotic surgery programme. The aim of this study was to evaluate a decade of paediatric robotic surgery and to reflect upon factors for success and to consider obstacles.MATERIALS AND METHODS: All children operated on with robotic-assisted laparoscopic surgery between 2006 and 2016 w

Superantigens (SAgs) are bacterial enterotoxins produced by Staphylococcus aureus. Staphylococcal enterotoxin type A (SEA), a staphylococcal superantigen, has been shown to bind to the cytokine signalling receptor glycoprotein 130 (gp130). The structural details, as well as the exact physiological role of this interaction, remain unclear. Here, we describe the structural details of the SEA–gp130 c

Residential energy consumption is a consequence of household members’ activities in their homes. Analysing and understanding energy consumption in households therefore needs to start from household activities and everyday life. From household members’ time diaries, we can analyse and learn about when, where and what energy-related activities occur in the household, involving what household members

The effects of diversity in management teams on firm innovation have become an important topic in strategic management. With a few exceptions, however, the literature has focused on diversity in top management teams (TMTs), while the role of diversity in lower management levels, particularly middle management teams (MMTs), has usually been neglected. In this paper, we intend to fill this gap by ex

Instruments play an essential role in creating research data. Given the importance of instruments and associated metadata to the assessment of data quality and data reuse, globally unique, persistent and resolvable identification of instruments is crucial. The Research Data Alliance Working Group Persistent Identification of Instruments (PIDINST) developed a community-driven solution for persisten

Lignin is the second most abundant biopolymer in nature and a promising renewable resource for aromatic chemicals. For the understanding of different lignin isolation and conversion processes, the identification of phenolic compounds is of importance. However, due to the vast number of possible chemical transformations, the prediction of produced phenolic structures is challenging, and a non-targe

Wild geese are increasing in agricultural and urban settings across Europe, leading to widespread human–geese interactions. This study examined how the public’s acceptance of geese (attitude and acceptance capacity) varied depending on place dimensions, interactions with geese in different settings (place-based experience), and psychological factors, including wildlife value orientations, beliefs