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Human adenoviruses (Ads) are broadly used in cancer gene therapy, vaccine development and gene delivery. The modified Ad5 or Ad2 viruses have been successfully used as oncolytic agents in pre-clinical studies. However they could not be translated into clinic utility due to a number of limitations including inefficient Ad spread among tumor cells. The cancer cell killing capacity of oncolytic Ad is
Denna uppsats undersöker hur formatet i en televiserad slutdebatt påverkar bilden av politik. Uppsatsen diskuterar moderatorns roll och på vilket sätt partiledarna har möjlighet att styra och sätta sin politik på dagordningen. Uppsatsen behandlar även hur partiledarna använder ethos, pathos och logos i sin argumentation får att stärka sin egen och partiets trovärdighet för att sätta sin politik på
In Sweden there are many people who take the food on our tables for granted, there is rarely anyone who reflects on the fact that it was hard work behind. The situation has not always been like that. During the late 1800s there were still many people living in rural areas and their livelihood was farming. Their jobs and mundane chore was to produce, if not the whole, but parts of the food that wou
Extreme heat and heatwaves constitute a growing challenge för municipal planning in relation to climate change. The aim of this study is to examine how risks related to extreme heat are addressed in the comprehensive planning of Malmö, Landskrona and Hässleholm, and also see how these approaches can be understood in relation to urban resilience and the PCCC framework created by Jabareen (2015) - P
This thesis focuses on molecular changes occuring during terminal B cell differentiation as well as on somatic hypermutation and the generation and maintenance of B cell memory. During T cell dependent immune responses the average affinity for the eliciting antigen increases with time. This affinity maturation is generated by somatic hypermutation and selection for B cells carrying a high-affinty
In plants, 14-3-3 proteins are key regulators of primary metabolism and membrane transport. It was previously thought that the 14-3-3 isoforms were not very specific with regard to target proteins, but more recent data suggest that the specificity may be high. Therefore, identification, localization, and characterization of all 14-3-3 isoforms in the model plant Arabidopsis are important. We ident
A gait re-education programme, combining physiotherapy with a psychologically conscious therapeutic approach, was applied to nine unilateral transfemoral amputees, whose amputation was caused by trauma or tumour. The participants trained once a week for a mean 10 months. The median age was 33 years (range 16– 51). They had worn a prosthesis for more than 18 months and had completed conventional re
The new generation of high resolution astronomical instruments such as the Hubble Space Telescope (HST) or the Very Large Telescope (VLT) has renewed the demand for accurate atomic parameters like wavelengths, oscillator strengths and line profiles accompanied by reliable uncertainty estimates. Fourier transform spectroscopy has proven to be a powerful tool when measuring these parameters. In this
Angiotensin II (Ang II) and endothelin-1 (ET-1) induce strong vasoconstriction via activation of receptors on vascular smooth muscle cells. In this thesis, the contractile Ang II and endothelin receptors were examined in endothelium-denuded human coronary arteries and in bypass grafts (the left internal mammary artery and the saphenous vein), with focus on receptor alterations in cardiovascular di
In this thesis, I have investigated conflicts of interest in the facultatively polygynous European starling (Sturnus vulgaris) with a focus on female reproductive strategies. The extent to which males provided parental care was a key issue in understanding the mating system of the starling. The amount of male parental care affected the quality of offspring. Polygynous males did not invest more in
Attosecond science refers to physical processes that occur on the natural timescale of electron motion in atomic and molecular systems. Attosecond time resolution can be obtained experimentally through a process called high-order harmonic generation where sharp attosecond pulses are formed in the time domain. Attosecond pulse trains contain many attosecond pulses with a constant pulse-to-pulse s
ABSTRACT Telomerase activity is a potential molecular marker for cancer and primitive cells in regenerative tissues. The most commonly used method to measure telomerase activity in cells is the telomerase reverse amplification protocol (TRAP) assay, where the protein extracts derived from homogenized cells are analysed. In this thesis we focused on developing a method where telomerase activity co
In this thesis, methods for automated analysis of myocardial perfusion single photon emission computer tomography (myocardial perfusion SPECT, MPS) images have been successfully developed and evaluated. MPS images show the perfusion of the myocardium and are used for diagnosing patients with suspected ischemic heart disease. The disease is characterized by reduced perfusion to a region of the myoc
Introduction/Background: Measurement of umbilical cord blood gasesat birth is the gold standard of capturing the metabolic state of the newborn. Dual sampling of umbilical cord vessels is mandatory, yet the longterm predictive value of venoarterial differences, ΔpH, remain undetermined. Previously, large ΔpH showed a protective effect against adverseneonatal outcomes.Objectives: To investigate the
