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Objective: The aim of this study was the validation of the criteria defining a significant mucocutaneous-bleeding history in type 1 von Willebrand disease (VWD). Subjects and methods: To avoid selection bias, 42 obligatory carriers (OC) of type 1 VWD were identified from a panel of 42 families with type 1 VWD enrolled by 10 expert centers. OC were identified by the presence of an offspring and ano

Popular Abstract in Swedish Blodförgiftningen (sepsis) kan ge upphov till akut hjärtsvikt, vilken på cellulär nivå karakteriseras av minskad känslighet för kalciumjonen och de vanliga hjärtförstärkande medicinerna (inotropa farmaka). Avhandlingen handlar om tidig behandling av sepsis-associerad hjärtsvikt med den kalciumsensitiseraren levosimendan, ett nytt läkemedel som höjer hjärtats kontraktionSepsis-related cardiovascular dysfunction associated with fluid-unresponsive tissue hypoperfusion might require inotropic treatment. This cardiovascular dysfunction seems to involve calcium desensitization and adrenergic unresponsiveness. We investigated the effects of clinically relevant plasma concentrations of the calcium sensitizer levosimendan during the first 6 h of endotoxemia in a model of

Land cover and land management changes (LCLMCs) have a substantial impact on the global carbon budget and, consequently, on global climate via the biogeochemical (BGC) effects. The commonly considered BGC effects refer to the direct influence of LCLMCs on local carbon stocks (local BGC effects). However, LCLMCs also influence climate by altering the local surface energy balance due to changes in l

Long-term noninvasive respiratory support, comprising continuous positive airway pressure (CPAP) and noninvasive ventilation (NIV), in children is expanding worldwide, with increasing complexities of children being considered for this type of ventilator support and expanding indications such as palliative care. There have been improvements in equipment and interfaces. Despite growing experience, t

Arbetet behandlar uppsåtsbegreppet i svensk och dansk rätt. Arbetet fokuserar särskilt på den nedre gränsen för uppsåt i svensk och dansk rätt. Uppsåt kan sägas innebära att någon gör en kriminaliserad gärning med vett och vilja. Domstolar, juridiska praktiker och teoretiker behöver dock ha ett mer preciserat uppsåtsbegrepp. I svensk rätt skiljer man på direkt, indirekt och eventuellt uppsåt, där

Popular Abstract in Swedish Syftet med den här studien är att undersöka utvecklingen av språkfärdigheten i skriftlig produktion av franska som främmande språk. Vi har följt 5 inlärares produktion av franska i en 30 månader lång longitudinell studie. För att kunna utvärdera färdigheten har vi använt oss av parametrarna flyt, komplexitet och korrekthet. Flyt och komplexitet har utvärderats med hjälpThe aim of this study is to examine the development of linguistic proficiency in written production of second-language French. In a longitudinal study of 30 months, we follow the written production of 5 guided learners of French as a second language. In order to apprehend proficiency we use the conventional parameters fluency, complexity and accuracy. The fluency and complexity are apprehended by

SAMHD1 degrades deoxyribonucleoside triphosphates (dNTPs), the building blocks of DNA. Davenne et al. find that SAMHD1 protects cells against dNTP imbalances. Exposure of SAMHD1-deficient cells to deoxyguanosine (dG) results in increased intracellular dGTP levels and subsequent apoptosis. This can be exploited to selectively kill cancer cells that acquired SAMHD1 mutations.

Context: Obesity and cardiometabolic diseases are associated with higher long-term glucocorticoid levels, measured as scalp hair cortisol (HairF) and cortisone (HairE). Cardiometabolic diseases have also been associated with copeptin, a stable surrogate marker for the arginine-vasopressin (AVP) system. Since AVP is, together with corticotropin-releasing hormone (CRH) an important regulator of the

The formation of α-synuclein aggregates is a major pathological hallmark of Parkinson's disease. Copper promotes α-synuclein aggregation and toxicity in vitro. The level of copper and copper transporter 1, which is the only known high-affinity copper importer in the brain, decreases in the substantia nigra of Parkinson's disease patients. However, the relationship between copper, copper transporte

Background: To use the European Association of Urology Research Foundation (EAURF) registry data to determine the proportion of contemporary Lower Urinary Tract Symptoms associated with Benign Prostatic Enlargement (LUTS/BPE) patients prescribed phytotherapy, and to determine their subjective quality of life and clinical progression responses. Methods: This was a prospective multicenter multinatio

Purpose: Glioblastoma multiforme (GBM) is the most common and lethal of primary malignant brain tumors. Hypoxia constitutes a major determining factor for the poor prognosis of high-grade glioma patients, and is known to contribute to the development of treatment resistance. Therefore, new strategies to comprehensively profile and monitor the hypoxic status of gliomas are of high clinical relevanc

HIGHLIGHTS • The Anthropocene compels unlocking of ocean-related network capabilities. • Orchestration of local, regional, and global knowledge networks can augment transformative capacity. • Transdisciplinary network diagnostics are promising social learning tools. • Strategic advice for transformational research in ocean territories are provided. This paper dedicates to understanding of what is

Background: Non-alcoholic fatty liver disease has been associated with increased mRNA expression of FADS2 in the liver and estimated activity of delta-6 desaturase in serum, encoded by the FADS2 gene. Since DNA methylation in the FADS1/2/3 gene cluster has been previously linked with genetic variants and desaturase activities, we now aimed to discover factors regulating DNA methylation of the CpG

Tau neuronal and glial pathologies drive the clinical presentation of Alzheimer's disease and related human tauopathies. There is a growing body of evidence indicating that pathological tau species can travel from cell to cell and spread the pathology through the brain. Throughout the last decade, physiological and pathological tau have become attractive targets for AD therapies. Several therapeut

G protein-coupled receptor 30 (GPR30) is a G protein-coupled receptor (GPCR) that is attracting considerable attention in breast cancer and cardiometabolic regulation. Following reports that GPR30 is required for some rapid estrogen responses, e.g. increased cAMP production and ERK1/2 activity, in estrogen receptor (ER)-negative cells, GPR30 was renamed G protein-coupled estrogen receptor 1 (GPER1

Atopic dermatitis (AD) is a clinically defined, highly pruritic, chronic inflammatory skin disease of children and adults. The diagnosis is made using evaluated clinical criteria. Disease activity is best measured with a composite score assessing both objective signs and subjective symptoms, such as SCORAD. The management of AD must consider the clinical and pathogenic variabilities of the disease

GPR30, or G protein-coupled estrogen receptor (GPER), is a G protein-coupled receptor (GPCR) that is currently attracting considerable attention in breast cancer and cardiometabolic regulation. The receptor was reported to be a novel membrane estrogen receptor mediating rapid non-genomic responses. However, questions remain about both the cognate ligand and the subcellular localization of receptor

Beside its classical role as a serum effector system of innate immunity, evidence is accumulating that complement has an intracellular repertoire of components that provides not only immune defense, but also functions to maintain cellular homeostasis. While complement proteins, mainly the central component C3, have been detected in B cells, their exact function and source remain largely unexplored