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Muscarinic acetylcholine receptors (mAChRs) play a central role in the mammalian nervous system. These receptors are G protein-coupled receptors (GPCRs), which are activated by the agonists acetylcholine and muscarine, and blocked by a variety of antagonists. Mammals have five mAChRs (m1-m5). In this study, we cloned two structurally related GPCRs from the fruit fly Drosophila melanogaster, which,
Eukaryotic cells have evolved quality control mechanisms to degrade aberrant mRNA molecules and prevent the synthesis of defective proteins that could be deleterious for the cell. The exosome, a protein complex with ribonuclease activity, is a key player in quality control. An early quality checkpoint takes place cotranscriptionally but little is known about the molecular mechanisms by which the e
Spectacular long-distance migration has evolved repeatedly in animals enabling exploration of resources separated in time and space. In birds, these patterns are largely driven by seasonality, cost of migration, and asymmetries in competition leading most often to leapfrog migration, where northern breeding populations winter furthest to the south. Here, we show that the highly aerial common swift
The Mediterranean Basin has experienced extensive change in geology and climate over the past six million years. Yet, the relative importance of key geological events for the distribution and genetic structure of the Mediterranean fauna remains poorly understood. Here, we use population genomic and phylogenomic analyses to establish the evolutionary history and genetic structure of common wall liz
Currently, little is known about the spatial distribution of white matter hyperintensities (WMH) in the brain of patients with Systemic Lupus erythematosus (SLE). Previous lesion markers, such as number and volume, ignore the strategic location of WMH. The goal of this work was to develop a fully-automated method to identify predominant patterns of WMH across WM tracts based on cluster analysis. A
BACKGROUND: We investigated the causality of IL-8 on carotid intima-media thickness (c-IMT), a measure of sub-clinical atherosclerosis.METHODS: The IMPROVE is a multicenter European study (n = 3,711). The association of plasma IL-8 with c-IMT (mm) was estimated by quantile regression. Genotyping was performed using the Illumina CardioMetabo and Immuno chips. Replication was attempted in three inde
Recent findings support the hypothesis that inhibition of SMYD3 methyltransferase may be a therapeutic avenue for some of the deadliest cancer types. Herein, active site-selective covalent SMYD3 inhibitors were designed by introducing an appropriate reactive cysteine trap into reversible first-generation SMYD3 inhibitors. The 4-aminopiperidine derivative EM127 (11C) bearing a 2-chloroethanoyl grou
The objective of this paper is to outline and discuss the key elements of an EU industrial development policy consistent with the Paris Agreement. We also assess the current EU Industrial Strategy proposal against these elements. The “well below 2 °C” target sets a clear limit for future global greenhouse gas emissions and thus strict boundaries for the development of future material demand, indus
Objectives: The aim of this study was to develop a model that can discriminate between different etiologies of abnormal uterine bleeding. Design: The International Endometrial Tumor Analysis 1 study is a multicenter observational diagnostic study in 18 bleeding clinics in 9 countries. Consecutive women with abnormal vaginal bleeding presenting for ultrasound examination (n = 2,417) were recruited.
Objective: Extended anticoagulation therapy should always be considered after standard treatment of an unprovoked episode of venous thromboembolism (VTE). It can also be considered for selected patients with provoked VTE. However, the evidence-based protocols suggested by some clinical guidelines and risk assessment tools to guide this practice are limited and ambiguous. The goal of the present su
BackgroundNon-coding genetic variants that influence gene transcription in pancreatic islets play a major role in the susceptibility to type 2 diabetes (T2D), and likely also contribute to type 1 diabetes (T1D) risk. For many loci, however, the mechanisms through which non-coding variants influence diabetes susceptibility are unknown.ResultsWe examine splicing QTLs (sQTLs) in pancreatic islets fro
Predicting Progression to Type 1 Diabetes from Ages 3 to 6 in Islet Autoantibody Positive TEDDY Children: Predicting Progression to T1D in TEDDY OR I G I N A L A R T I C L E Predicting progression to type 1 diabetes from ages 3 to 6 in islet autoantibody positive TEDDY children Laura M. Jacobsen1 | Helena E. Larsson2 | Roy N. Tamura3 | Kendra Vehik3 | Joanna Clasen3 | Jay Sosenko4 | William A. Hag
https://www.teddy.lu.se/sites/teddy.lu.se/files/05072019_679_102_mp62_jacobsen_peddiab_2019_0.pdf - 2026-05-16
Lärosäten Syd – Universities in South Sweden | Website larosatensyd.se/en Date: 2025-11-26 Author: Martin Jönsson, Trainee, Universities in South Sweden Brussels Representation, autumn semester 2025 The future of the European Common Agricultural Policy in the next Multiannual Financial Framework An analysis of the political, budgetary and governance tensions shaping the proposed post-2027 Common A
https://www.mgeo.lu.se/en/sites/mgeo.lu.se.en/files/2026-01/CAP_PolicyBriefing_2025_2.pdf - 2026-05-16
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https://www.folklivsarkivet.lu.se/fileadmin/user_upload/folklivsarkivet/upload/stadstrad/Kalmar.pdf - 2026-05-14
Wpss 85 WORKING PAPERS IN SCANDINAVIAN SYNTAX 85 Mayumi Hosono Scandinavian Object Shift as the Cause of Downstep 1–36 Jackie Nordström The Swedish så-construction, a new point of departure 37–63 Anton Karl Ingason Productivity of Non-Default Case 65–117 June 2010 Working Papers in Scandinavian Syntax ISSN: 1100-097x Christer Platzack ed. Centre for Languages and Literature Box 201 S-221 00 Lund,
https://projekt.ht.lu.se/fileadmin/_migrated/content_uploads/WPSS_06.pdf - 2026-05-14
Microsoft Word - AFRINT REPORT 21-09-03.doc A MICRO LEVEL ANALYSIS OF AGRICULTURAL INTENSIFICATION IN KENYA: THE CASE OF FOOD STAPLES Final Report Prepared by Joseph T. Karugia1 Department of Agricultural Economics University of Nairobi SEPTEMBER 2003 1. The research inputs by S. K. Wambugu, and Lucy W. Ngare and the field enumerators are highly appreciated. i Table of Contents 1. INTRODUCTION ...
https://www.keg.lu.se/en/sites/keg.lu.se.en/files/a12.pdf - 2026-05-16
Microsoft Word - Avfallshandbok för Biologicentrum-1.docx Avfallshandbok för Biologiska institutionen Dokumentets namn Gäller för Dnr Sida Avfallshandbok Lunds universitet V 2015 - 1404 2 (64) Utarbetad av Miljösamordare Godkänd av Miljöchef Utgåva 1 1 Datum 2015-10-08 INNEHÅLL 1. Inledning ............................................................................................................
https://www.biologi.lu.se/internt/sites/biologi.lu.se.internt/files/avfallbiologi.pdf - 2026-05-16
THESIS.PDF LUMES MASTER’S THESIS 1999/2000 TOWARDS SUSTAINABLE LANDUSE WITHIN ACID SULFATE SOIL LANDSCAPES: A Case Study on the Maria River, New South Wales Australia. By Thor Aasø Hebegatan 3 416 59 Göteborg 031 217922 thor.aaso.479@student.lu.se Supervisor: Christer Kalén Plant Ecology Lund University Sweden Telephone: 046-2223754 Fax: 046-2224423 Email: Christer.Kalen@planteco.lu.se Lund Univer
https://www.lumes.lu.se/sites/lumes.lu.se/files/aaso_thor.pdf - 2026-05-16
Lund University Master's Programme in Environmental Science Lund University Master of Science Thesis The Use of Hydrogen as an Energy Carrier for the Private and Public Transport Sector in Germany by Franc Grimm Höhenweg1a, 23617KleinFarin,Gennany supervised by Åhman , Max, 046-222 86 43 Department of Environmental and Energy Systems Studies Bytaregatan 20,22221 Lund, Max.Ahman@miljo.1th.se Grubel
https://www.lumes.lu.se/sites/lumes.lu.se/files/grimm_franc.pdf - 2026-05-16
LUMES 2001/2002 LLUUMMEESS 22000011//22000022 IInntteerrnnaattiioonnaall mmaasstteerr’’ss pprrooggrraamm iinn eennvviirroonnmmeennttaall sscciieennccee--LLUUMMEESS EEnnvviirroonnmmeennttaallllyy bbaasseedd ttrreeaattmmeenntt ooff ssoolliidd wwaassttee iinn uurrbbaann aanndd sseemmii uurrbbaann aarreeaass ooff CCaammeerroooonn BByy TTaappoonngg SSyyllvveesstteerr EEmmaaiill:: ttaappoonnggssyyllvvee
https://www.lumes.lu.se/sites/lumes.lu.se/files/tapong_sylvester.pdf - 2026-05-16
