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Among the common complex diseases, hypertension has been particularly unlucky in the recent surge of positive results from genome-wide association studies. We summarize the evidence that would support continuing the effort in the hunt for a genetic basis for hypertension. The problems facing the genetic studies for hypertension are not unique, but phenotypic characterization, heterogeneity and hig

Smooth muscle is a slow and economical muscle with a large variability in contractile properties. This review describes results regarding the relation between expression of myosin isoforms and the contraction of smooth muscle. The focus of the review is on studies of the organised contractile system in the smooth muscle tissue. The role of the myosin heavy chain variants formed by alternative spli

The nonreceptor tyrosine kinase Src binds to and is activated by the beta-receptor for platelet-derived growth factor (PDGF). The interaction leads to Src phosphorylation of Tyr934 in the kinase domain of the receptor. In the course of the functional characterization of this phosphorylation, we noticed that components of 136 and 97 kDa bound to a peptide from this region of the receptor in a phosp

BACKGROUND Paroxysmal nocturnal haemoglobinuria (PNH) is a rare haematological disease characterised by chronic haemolysis, pancytopenia and venous thrombosis. The condition is attributable to a lack of control of complement attack on erythrocytes, thrombocytes and leukocytes, and can be diagnosed by means of flow cytometry. In this quality assurance study, we have reviewed information from the me

Cardiovascular disease is multidimensional and new ideas are needed to develop the conventional risk factor paradigm that has been based on the Framingham Heart Study since more than 30 years. Traditional risk factors such as hypertension, smoking, hyperlipidemia and diabetes can only explain about 50% of the distribution of coronary heart disease whereas the inclusion of new risk markers or prote

The focus of this project has been to find a method on how to do production improvements systematically in the case of manufacturing by means of metal cutting operations. Typically every company determines their cutting data with the help of previous experiences as well as recommendations made by the tool manufacturers. These chosen cutting data may be the optimal settings for the specific operati

Compressed sensing (CS) is a universal low-complexity data compression technique for signals that have a sparse representation in some domain. While CS data compression can be done both in the analog- and digital domain, digital implementations are often used on low-power sensor nodes, where an ultra-low-power (ULP) processor carries out the algorithm on Nyquist-rate sampled data. In such systems

The ECL cells in the stomach produce, store and secrete a variety of secretory products, such as histamine and chromogranin A-derived peptides (e.g. pancreastatin). The functional significance of the ECL cells can be expected to reflect the nature/bioactivity of the secreted products. Although the anticipated peptide hormone of the ECL cells remains unidentified, ECL-cell histamine is recognized a

Popular Abstract in Swedish Arbetet har bestått av att dels experimentellt samt dels med hjälp av matematiska modeller undersöka och kartlägga förloppen för nya samt "gamla" metoder att rena rökgaser från kol- och olje eldade kraftverk.

Popular Abstract in Swedish I slutet av 1800-talet gjordes upptäckten att atomer bara kan ta upp eller sända ut ljus med vissa våglängder. Denna egenskap beror på att elektronerna endast kan befinna sig i ett av flera diskreta energitillstånd. Man säger att elektronerna är kvantiserade. Kvantiseringen är en effekt av att elektronerna i en atom tvingas hålla sig inom en mycket liten volym. Ju mindr

Telomeric DNA generally comprises a repetitive, noncoding sequence which terminates in a single‑stranded extension, the 3' overhang. Although these species‑specific repeats show a large diversity in sequence and length, they comprise some specific characteristic conserved features. Therefore, analyses of the telomeric repeats of various organisms have delivered important insights concerning the or

The European project Nature-SDIplus has developed data and metadata specifications for three INSPIRE Annex III themes: Habitat and Biotopes, Bio-geographical regions and Species distributions. These serves as a foundation for the thematic groups developing the corresponding INSPIRE specifications. The aim of this study is to test a data harmonization approach to make Swedish environmental geodata