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Complex surface reconstructions solved by ab initio molecular dynamics

Complex surface reconstructions and surface oxides, in particular, often exhibit complicated atomic arrangements, which are difficult to resolve with traditional experimental methods, such as low energy electron diffraction (LEED), surface X-ray diffraction (SXRD) or scanning tunnelling microscopy (STM) alone. Therefore, ab initio density functional calculations are used as a supplement to the exp

Dissection of the genetic complexity of arthritis using animal models.

Rheumatoid arthritis (RA) is a chronic inflammatory disease directed towards peripheral joints. As all common diseases it is associated with several genes and a multitude of environmental factors. In addition, in similarity with most other complex diseases, it is defined only on the basis of clinical signs and symptoms, it is therefore more properly classified as a syndrome rather than a distinct

Breast cancer-amplified sequence 3, a target of metastasis-associated protein 1, contributes to tamoxifen resistance in premenopausal patients with breast cancer

Lysine acetylation occurs in many protein targets, including core histones, transcription factors, and other proteins. Metastasis-associated protein 1 (MTA1) is implicated in the progression and metastasis of various epithelial tumors. Because MTA1 functions as a transcriptional coregulator, much of its role in cancer promoting processes are likely to involve its ability to regulate the transcript

Urmia Lake Watershed Restoration in Iran: Short- and Long-Term Perspectives

Urmia Lake (also known as Oroumieh Lake) is a shallow terminal lake located in northwest Iran and one of the largest permanent lakes in the Middle East. Due to its biodiversity it has been designated as a Biosphere Reserve by UNESCO and a National Park under the 1971 Ramsar Convention. At present, the entire lake’s watershed is threatened due to drought and abrupt decline of the lake’s water level

Negotiations on information-seeking expertise: A study of web-based tutorials for information literacy

Abstract: Purpose – The purpose of this paper is to show how different approaches to information literacy, such as are mediated through web-based tutorials, are used as tools in negotiating the information-seeking expertise of university librarians. Design/methodology/approach – A textual analysis of 31 web-based Scandinavian tutorials for information literacy has been conducted. The similarities

Organizational factors affecting product innovation capability: Findings from the Med-Tech industry

Research in innovation has resulted in much applicable knowledge in terms of tools, methods and processes. However, the challenge of allowing “space”, time and competence for innovation capability development is sparsely reported. The purpose of this research is to identify how organizational and behavioral factors affect product innovation capability and its development in organizations. The rese

Evaluation of heterogeneity of DNA ploidy in early gastric cancers

DNA ploidy has been shown to be a predictive parameter for prognosis in various solid tumours. The prognostic value of DNA-ploidy in gastric cancers is still a matter of controversy. A possible explanation for the discrepant results reported in the literature could be sampling error in tumours with multiple stemlines differing in DNA-ploidy. In order to determine whether or not such heterogeneity

Novel pyrazolate-based copper(II) [2 x 2] grid complexes: Synthesis, structure and properties

5-Acetyl-substituted pyrazole-3-carboxylic acid (H2L) forms [2 x 2] grid-like tetranuclear Cu(II) complexes with four five-coordinated copper(II) ions bridged by pyrazolate groups. Despite a significant dissociation of [Cu4L4(H2O)(4)]center dot 4H(2)O (1) in aqueous solution(1), it was possible to substitute the coordinated water molecules by pyridine ligands or azide anions. The resulting tetranu