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Genetic, molecular and functional analyses of factor I - an inhibitor of the complement system

Factor I (FI) is a serine protease that inhibits the complement system by cleaving activated C3 and C4 complement proteins, in the presence of cofactors. Mutations in the gene coding for FI have been identified in complete FI deficient- and atypical hemolytic uremic syndrome (aHUS) patients. The mutations were introduced in recombinantly expressed proteins, purified and analyzed in functional ass

Effects of substitutions in the CXXC active-site motif of the extracytoplasmic thioredoxin ResA

The thiol-disulfide oxidoreductase ResA from Bacillus subtilis fulfils a reductive role in cytochrome c maturation. The pK(a) values for the CEPC (one-letter code) active-site cysteine residues of Ill are unusual for thioredoxin-like proteins ill that they are both high (> 8) and within 0.5 unit of each other. To determine the contribution of the inter-cysteine dipeptide of ResA to its redox and a

Embedding Mono code in unmanaged applications on GNU/Linux

In today’s society more and more work is carried out with the help of dif- ferent computer systems. To benefit from the data, integration between the systems is needed. Saab has developed a solution to the problem, by the name WISE. With a modular design costs can be minimized, because a new integration does not necessarily require new software, but can be achieved with configuration of an existin

Blanket Retention of Electronic Communications Traffic Data and the Right to Respect for Private Life - Sweden in Focus

Detta examensarbete rör direktiv 2006/46/EG och dess överensstämmelse med den europeiska konventionen om skydd för de mänskliga rättigheterna och de grundläggande friheterna. Examensarbetet använder Sverige som ett exempel, och analyserar främst lagen (2003:389) om elektronisk kommunikation och dess tillkortakommanden vad gäller brottsbekämpande myndigheters tillgång till lagrade trafikuppgifter. This thesis concerns Directive 2006/46/EC and its compliance with the European Convention on Human Rights and Fundamental Freedoms. The thesis uses Sweden as an example, and mainly analyses the shortcomings in Swedish legislation on how traffic data may be accessed by law enforcement authorities, finding that the regulations under the Swedish Electronic Communications Act breaches Article 8 and 13

Prenatal diagnosis of congenital heart defects-a population based study.

Aim: The aim of this study was to describe the efficiency of routine prenatal ultrasound screening for the detection of cardiac defects in a Swedish region and to study the effect of prenatal diagnosis on the survival and outcome of the child. Methods: We identified all fetuses and infants with a diagnosed major cardiac defect born in 1999-2003 in a region of Sweden using a register of the regiona

Large eddy simulation of unsteady lean stratified premixed combustion

Premixed turbulent flame-based technologies are rapidly growing in importance, with applications to modern clean combustion devices for both power generation and aeropropulsion. However, the gain in decreasing harmful emissions might be canceled by rising combustion instabilities. Unwanted unsteady flame phenomena that might even destroy the whole device have been widely reported and are subject t

A clinically applicable method for determining the three major alleles at the Duffy (FY) blood group locus using polymerase chain reaction with allele-specific primers

BACKGROUND: The clinically significant antigens of the Duffy (Fy [FY]) blood group system are expressed on the red cell form of the FY glycoprotein, a promiscuous chemokine receptor and also a receptor for malarial parasites. After the cloning of cDNA coding for FY glycoprotein, the molecular basis of the three major alleles (Fya/Fyb/Fy) has been established. Because of the mistyping of the silent

Alport syndrome caused by inversion of a 21 Mb fragment of the long arm of the X-chromosome comprising exon 9 through 51 of the COL4A5 gene

The X-linked form of Alport syndrome (AS) is caused by mutation in the COL4A5 gene located at Xq22.3 and encoding the alpha 5-chain of type IV-collagen. More than 400 different mutations have so far been detected in the COL4A5 gene. Not all mutations, however, will be detected using an exon-by-exon mutation detection strategy such as SSCP analysis or direct sequencing. We have previously reported

Probing dark matter with disappearing tracks at the LHC

Models where dark matter is a part of an electroweak multiplet feature charged particles with macroscopic lifetimes due to the charged-neutral mass split of the order of pion mass. At the Large Hadron Collider, the ATLAS and CMS experiments will identify these charged particles as disappearing tracks, since they decay into a massive invisible dark matter candidate and a very soft charged Standard-

Improving human papillomavirus (HPV) testing in the cervical cancer elimination era : The 2021 HPV LabNet international proficiency study

Background: Proficient Human Papillomavirus (HPV) genotyping services are essential to support HPV and cervical cancer elimination strategies, in particular to support HPV vaccine research. Objectives: To perform a global HPV genotyping proficiency study, with evaluation in relation to previous proficiency studies. Study design: The proficiency panel contained 44 coded samples (40 samples containi

Psp 201014 nr7 protokoll

PROTOKOLL 7:2020 Dnr STYR 2020/1688 LUNDS UNIVERSITET Institutionen för psykologi ledningsgruppen för psykologprogrammet Sammanträdesdatum 2020-10-14 Närvarande ledamöter Jonas Bjärehed Kristian Almquist Bengt Brattgård Daiva Daukantaite Dariush Djamnezhad Tomas Jungert Tomas Kempe Jens Knutsson Erik Lundin Bertil Persson Elia Psouni Elinor Schad Margit Wångby Lundh Anita Lennerstedt Närvaro- och

https://www.psy.lu.se/sites/psy.lu.se/files/psp_201014_nr7_protokoll.pdf - 2026-05-20

Adaptive Tactics in Software Operations: How People Manage Complexity by Asking for Help

Society relies on the continued operation of software systems, from healthcare to social media platforms. These systems can be engineered to be highly reliable, but complexity assures surprise. People have the ability to manage this complexity, filling gaps in design by recognizing, diagnosing and correcting anomalies. Rarely can surprises be managed by individuals alone. When engaged in anomaly r

Modelling of Potential Swedish 2022 Forest Fire Areas

Forest fires are a danger both to society and to the climate. The forestry sector is an important and large element of Sweden’s economy, nature and landscape. Forest fires directly impact the economic viability of the forest industry and the people dependant on it. Forest fires also impact society, by necessitating measures to combat and prevent forest fires, and endangering human lives. A key par

Beyond Bloodshed Investigating Justice in Rape-Revenge Films

Victims of sexual violence face trauma and systemic hurdles in seeking rectification after the crime, leaving viable justice formations complex and scattered. Adressing the issue of sexual violence, the rape-revenge filmgenre provides a platform for justice and feminist discourse to flourish. Focusing on the the rape-revenge films Promising Young Woman, M.F.A., and Three Billboards Outside Ebbing,

Abstracts 25 4 1

Wednesday 25 April 2018 09:15 – 12:00 Pufendorf IAS seminar room, 2nd floor, Biskopsgatan 3, Lund 221 00 Abstracts and Presentations Title: Media Constructions of the Refugee Crisis Discourse The presentation will focus on media representations of the “refugee crisis”, particularly of Syrian re- fugees, in mainstream daily newspapers in Sweden, Jordan and Turkey. Focusing on 2015, the year in whic

https://www.pi.lu.se/sites/pi.lu.se/files/abstracts_25_4_1.pdf - 2026-05-20

Slutet för företagskontrollerade fabriksrevisioner? : En studie om fabriksrevisioners tänkta framtida utveckling utifrån tre aktörskategorier

Fabriksrevision används som ett verktyg för att kontrollera att leverantörer och underleverantörer uppfyller kraven i kontraktsvillkor och det är ett steg i uppföljningsprocessen. I decennier har det rapporterats om arbetsrättsliga- och människorättsliga kränkningar i globala leveranskedjor där fabriksrevision används som en mekanism för att säkerställa goda arbetsvillkor. Dock kritiseras fabriksrSocial audits are used as a tool for performing reviews on suppliers’ and sub-suppliers’ compliance towards contractual obligations and is a step in the review process. There have been reports of violation of labor- and human rights laws in the global supply chains where social audits are put in place to secure good working conditions. Business segments have been criticized to have failed on their

Fallenhet för media multitasking och prestation i episodiska minnesuppgifter: En experimentell kvantitativ studie

I denna studie undersökte vi korrelationen mellan fallenhet till multitasking och minnesprestation i episodiska minnesuppgifter för detaljer och associationer. Hypotesen var att personer med hög fallenhet till multitasking skulle prestera bättre i minnesuppgifter gällande minnen för associationer, och personer med låg fallenhet till multitasking skulle prestera bättre i minnesuppgifter gällande miIn this study we investigated the correlation between inclination to multitasking and memory performance in episodic memory tasks for details and associations. The hypothesis was that people with a high inclination to multitasking would perform better in memory tasks regarding memories for associations, and people with a low inclination to multitasking would perform better in memory tasks regardin

Kommunala miljöförvaltningars tillsyn av vård-/äldreboendes beredskap för värmeböljor

Att man blir trött och hängig av värme känner nog de flesta till, men de flesta av oss klarar det tack vare skugga, solskydd och vätska. Men under en intensiv och långvarig värmebölja kan det bli riktigt allvarligt om du är äldre och samtidigt har en i övrigt vacklande hälsa. Under senare år och inte minst under den senaste värmeböljan sommaren 2018 insåg många verksamhetsutövare för vård-/äldreboIn recent years, heat waves have begun to be perceived as one of the biggest problems due to climate change. The Public Health Agency, which is the national supervisory guidance regarding health effects, has therefore updated its guidelines to ensure that regions and municipalities have sufficient information to carry out inspections in accordance with the Environmental Code. This study focuses