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Factor I (FI) is a serine protease that inhibits the complement system by cleaving activated C3 and C4 complement proteins, in the presence of cofactors. Mutations in the gene coding for FI have been identified in complete FI deficient- and atypical hemolytic uremic syndrome (aHUS) patients. The mutations were introduced in recombinantly expressed proteins, purified and analyzed in functional ass
Background. T-cell lymphoblastic lymphoma (T-LBL) is a rare neoplasm of precursor lymphoblast origin, for which there is no standard treatment for adults. Results of current treatment strategies in selected populations do exist but are largely unreported for unselected series. Here, we aimed to investigate treatment outcome in a population-based cohort. Material and methods. Patients were identifi
The thiol-disulfide oxidoreductase ResA from Bacillus subtilis fulfils a reductive role in cytochrome c maturation. The pK(a) values for the CEPC (one-letter code) active-site cysteine residues of Ill are unusual for thioredoxin-like proteins ill that they are both high (> 8) and within 0.5 unit of each other. To determine the contribution of the inter-cysteine dipeptide of ResA to its redox and a
In today’s society more and more work is carried out with the help of dif- ferent computer systems. To benefit from the data, integration between the systems is needed. Saab has developed a solution to the problem, by the name WISE. With a modular design costs can be minimized, because a new integration does not necessarily require new software, but can be achieved with configuration of an existin
Detta examensarbete rör direktiv 2006/46/EG och dess överensstämmelse med den europeiska konventionen om skydd för de mänskliga rättigheterna och de grundläggande friheterna. Examensarbetet använder Sverige som ett exempel, och analyserar främst lagen (2003:389) om elektronisk kommunikation och dess tillkortakommanden vad gäller brottsbekämpande myndigheters tillgång till lagrade trafikuppgifter. This thesis concerns Directive 2006/46/EC and its compliance with the European Convention on Human Rights and Fundamental Freedoms. The thesis uses Sweden as an example, and mainly analyses the shortcomings in Swedish legislation on how traffic data may be accessed by law enforcement authorities, finding that the regulations under the Swedish Electronic Communications Act breaches Article 8 and 13
Aim: The aim of this study was to describe the efficiency of routine prenatal ultrasound screening for the detection of cardiac defects in a Swedish region and to study the effect of prenatal diagnosis on the survival and outcome of the child. Methods: We identified all fetuses and infants with a diagnosed major cardiac defect born in 1999-2003 in a region of Sweden using a register of the regiona
Premixed turbulent flame-based technologies are rapidly growing in importance, with applications to modern clean combustion devices for both power generation and aeropropulsion. However, the gain in decreasing harmful emissions might be canceled by rising combustion instabilities. Unwanted unsteady flame phenomena that might even destroy the whole device have been widely reported and are subject t
BACKGROUND: The clinically significant antigens of the Duffy (Fy [FY]) blood group system are expressed on the red cell form of the FY glycoprotein, a promiscuous chemokine receptor and also a receptor for malarial parasites. After the cloning of cDNA coding for FY glycoprotein, the molecular basis of the three major alleles (Fya/Fyb/Fy) has been established. Because of the mistyping of the silent
The X-linked form of Alport syndrome (AS) is caused by mutation in the COL4A5 gene located at Xq22.3 and encoding the alpha 5-chain of type IV-collagen. More than 400 different mutations have so far been detected in the COL4A5 gene. Not all mutations, however, will be detected using an exon-by-exon mutation detection strategy such as SSCP analysis or direct sequencing. We have previously reported
Models where dark matter is a part of an electroweak multiplet feature charged particles with macroscopic lifetimes due to the charged-neutral mass split of the order of pion mass. At the Large Hadron Collider, the ATLAS and CMS experiments will identify these charged particles as disappearing tracks, since they decay into a massive invisible dark matter candidate and a very soft charged Standard-
Background: Proficient Human Papillomavirus (HPV) genotyping services are essential to support HPV and cervical cancer elimination strategies, in particular to support HPV vaccine research. Objectives: To perform a global HPV genotyping proficiency study, with evaluation in relation to previous proficiency studies. Study design: The proficiency panel contained 44 coded samples (40 samples containi
Årshögtid LUNDS UNIVERSITET | 31 JANUARI 2025 Produktion och layout: Akademiintendenturen vid Lunds universitet Foto: Omslag: Kennet Ruona. Sida 7, 10-13: Kennet Ruona. Sida 8: Johan Persson. Sida 9: Marco Borggreve. Sida 14: Henrik Karström. Skribent: Sida 9-14: Minna Wallén-Widung Upplaga: 500 ex. 978-91-8104-386-0 (tryckt) 978-91-8104-387-7 (elektronisk) Tryck: Media-Tryck, Lunds universitet, L
pnas201210582 1..3 Profile of Anders Björklund W hen Anders Björklund star- ted medical school in the early 1960s, scientists still believed that the structure of the adult brain was fixed and immuta- ble and that nerve cells could not be regenerated after damage or death. But that view changed when Björklund began using a powerful new fluorescence mi- croscopic method to view subsets of neurons.
Society relies on the continued operation of software systems, from healthcare to social media platforms. These systems can be engineered to be highly reliable, but complexity assures surprise. People have the ability to manage this complexity, filling gaps in design by recognizing, diagnosing and correcting anomalies. Rarely can surprises be managed by individuals alone. When engaged in anomaly r
Forest fires are a danger both to society and to the climate. The forestry sector is an important and large element of Sweden’s economy, nature and landscape. Forest fires directly impact the economic viability of the forest industry and the people dependant on it. Forest fires also impact society, by necessitating measures to combat and prevent forest fires, and endangering human lives. A key par
Victims of sexual violence face trauma and systemic hurdles in seeking rectification after the crime, leaving viable justice formations complex and scattered. Adressing the issue of sexual violence, the rape-revenge filmgenre provides a platform for justice and feminist discourse to flourish. Focusing on the the rape-revenge films Promising Young Woman, M.F.A., and Three Billboards Outside Ebbing,
Lund 31 August 2017 A Million Rivers- Movie Screening and Director’s talk On Thursday 14 September at 19.00 director Sarah Singh comes to Skissernas Museum (Museum of Sketches for Public Art) in Lund to screen "A Million Rivers”. Radically re-inventing the geo-political narrative through themes of fragmentation, identity, loss, fantasy, secrecy, and desire award-winning director Sarah Singh contin
https://www.sasnet.lu.se/sites/sasnet.lu.se/files/lund_31_august_2017.docx - 2026-05-20
Fabriksrevision används som ett verktyg för att kontrollera att leverantörer och underleverantörer uppfyller kraven i kontraktsvillkor och det är ett steg i uppföljningsprocessen. I decennier har det rapporterats om arbetsrättsliga- och människorättsliga kränkningar i globala leveranskedjor där fabriksrevision används som en mekanism för att säkerställa goda arbetsvillkor. Dock kritiseras fabriksrSocial audits are used as a tool for performing reviews on suppliers’ and sub-suppliers’ compliance towards contractual obligations and is a step in the review process. There have been reports of violation of labor- and human rights laws in the global supply chains where social audits are put in place to secure good working conditions. Business segments have been criticized to have failed on their
