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PURPOSE: Clinical relapse is the major threat for patients with myelodysplastic syndrome (MDS) undergoing hematopoietic stem-cell transplantation (HSCT). Early detection of measurable residual disease (MRD) would enable preemptive treatment and potentially reduced relapse risk.METHODSPatients with MDS planned for HSCT were enrolled in a prospective, observational study evaluating the association b

Purpose: To study the feasibility of automatically identifying normal digital mammography (DM) exams with artificial intelligence (AI) to reduce the breast cancer screening reading workload. Methods and materials: A total of 2652 DM exams (653 cancer) and interpretations by 101 radiologists were gathered from nine previously performed multi-reader multi-case receiver operating characteristic (MRMC

Taurine, an amino sulfonic acid abundant in seafood and meat, has been proposed to have a potential role in the prevention of metabolic dysfunction-associated steatotic liver disease (MASLD) due to its antioxidant and anti-inflammatory properties. However, the association between dietary taurine intake and MASLD remains unclear in human populations. Also, data on dietary taurine intake among adult

Cell migration is the first step of the invasive process, which is part of the malignant phenotype, and the uPA receptor (uPAR) plays a central role in cell migration. We studied the role of EGF and estrogen on cell migration and uPAR expression in ovarian cancer cell lines. We also analyzed the diagnostic and prognostic value of cleaved forms of the uPAR in plasma from patients with ovarian tumor

Human skin fibroblasts in different growth states were incubated with [3H]glucosamine and/or Na(2)35SO4 and extracted with Triton X-100 for various periods of time. Free heparan-sulphate oligosaccharides and protein-bound heparan-sulphate chains were separated by chromatography on octyl-Sepharose and analyzed. A pool of endogenously produced oligosaccharides, present in the cultured cells and isol

The Gaia mission has been designed to perform absolute astrometric measurements with unprecedented accuracy; the end-of-mission parallax standard error is required to be of the order of 10 mu as for the brightest stars (V= 10) and 30 mu as for a G2V-type star of magnitude 15. These requirements set a stringent constraint on the accuracy of the estimation of the location of the stellar image on the

Cellobiose dehydrogenase (CDH) is a monomeric extracellular flavocytochrome composed of a catalytic dehydrogenase domain (DHCDH) containing flavin adenine dinucleotide (FAD), a cytochrome domain (CYTCDH) containing heme b, and a linker region connecting the two domains. In this work, the effect of deglycosylation on the electrochemical properties of CDH from Phanerochaete chrysosporium (PcCDH) and

Aim: The aim of this study was to describe the efficiency of routine prenatal ultrasound screening for the detection of cardiac defects in a Swedish region and to study the effect of prenatal diagnosis on the survival and outcome of the child. Methods: We identified all fetuses and infants with a diagnosed major cardiac defect born in 1999-2003 in a region of Sweden using a register of the regiona

What are the social positions of adults who were in long-term foster care as children, compared with the general population and with adults who grew up at home in families similar to foster children's birth families? How common is it to have been in foster care? Four approaches are used in this study: - A systematic review of around 50 studies on adult foster children. Conclusions are more pessim

During my time as Director of Studies at the Municipal Music School of Lund, Sweden, I have had several discussions with teachers, students, parents, municipality civil servants, and politicians. I have concluded that in general, culture schools and music schools are looked upon as institutions where parents safely can send their children convinced about that they get a qualified education regardi

Aims: During recent years, two strategies of incretin-based therapy [glucagon-like peptide-1 (GLP-1) receptor agonism and dipeptidyl peptidase-4 (DPP-4) inhibition] have entered the market for pharmacological management of type 2 diabetes. A main indication for this therapy is as add-on to on-going metformin therapy in subjects with type 2 diabetes who have insufficient glycaemic control with metf

Popular Abstract in Swedish Arbetet i denna avhandling presenteras i 6 olika delarbeten (artiklar I-VI). Artiklarna I-III behandlar två olika enzymer som bryter ner cyklodextriner, vilka är ringformade molekyler med samma beståndsdelar som i stärkelse (dvs sammanlänkade glukosmolekyler). Dessa s.k. cyklodextrinaser kommer ursprungligen från två bakterier som har isolerats i varma källor på Island.Two putative cyclodextrinases (CDases) were amplified from two moderate thermophiles isolated in Iceland: Anoxybacillus flavithermus and Laceyella sacchari. They were cloned, expressed and characterized. The expression of the former was optimized in E. coli by using a solubility-enhancing tag, NusA, and tuning of inducer concentration in the expression strain Tuner(DE3). The CDases were optimally

For how many years was a farmer responsible for running a farm in Sweden’s old peasant society’? This is the question that underpins my research into life in Ramkvilla parish in the province of Småland for two hundred years (1623–1819). By conducting a detailed study of farm practice at the individual level, I have been able to analyse a complex theme that touches upon the issues of responsibility

Appreciation and production of musical rhythm is a human universal and, as with other human capacities, it is imperative to understand the extent of our capacity to perceive and produce rhythm. This thesis presents my work on the cognitive and perceptual aspects of rhythm perception and production at a slow tempi. In Paper I I establish that rhythm production, such as keeping the beat to a metron

Swedish penal law does not exculpate on the grounds of diminished accountability; persons judged to suffer from severe mental disorder are sentenced to forensic psychiatric care instead of prison. Re-introduction of accountability as a condition for legal responsibility has been advocated, not least by forensic psychiatric professionals. To investigate how professionals in forensic psychiatry woul

Cryptocurrencies are on the rise, with new financial assets, new frameworks need to be developed. This thesis sets out to the examine the GARCH(1,1), the bivariate-BEKK(1,1), and the Standard stochastic volatility model’s volatility forecasting performance on BTC/USD, where the bivariate model is estimated on both BTC/USD and ETH/USD closing price data. Furthermore, three loss functions are used t

The labor market, and therefore employment conditions, has changed in recent decades. Today, flexibilisation has led to a large number of employees who work part-time or lack permanent employment. An involuntary part-time worker refers to an individual who is working part-time and states that they want to work more hours than what the employer offers. As long as the employer complies with the prov

Popular science summary: An MK-801 Hyperactivity Model in Zebrafish Larvae Schizophrenia is a mental disorder characterized by psychosis, depression and cognitive impairments. The severity of this disease is easily underestimated, since the manifestations are not consequently lethal. Additionally, Schizophrenia is correlated with a 50 times increased risk of attempted suicide. Considering that a

The accession to the European Union was based on the financial gains that could be made on the single market. When acceding the Union the Member States gave up parts of their state sovereignty. This statement is not unproblematic. My thesis touches on the posting of workers. Since the adoption of the new Enforcement Directive on the Posting of Workers Directive, two reports on the Swedish impleme

A plant’s rain coat Imagine yourself taking a walk on a cloudy day. Suddenly, the sky opens and the rain is pouring down making you totally soaked. Now imagine that you predicted that it would start to rain so you put on a rain coat. When the rain starts to fall, you won’t get wet since the rain drops will strike against the rain coat and get drained. In the same manner, the wax on plants is prot