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The association of the metabolic syndrome with target organ damage : focus on the heart, brain, and central arteries

Introduction: The metabolic syndrome (MetS) is an adverse metabolic state composed of obesity, hyperglycemia/pre-diabetes, hypertension, and dyslipidemia. It substantially increases the risk of type 2 diabetes, cardiovascular disease (CVD) and mortality, and has a huge impact on public health. Area covered: The present review gives an update on the definition and prevalence of MetS, and its impact

Study of a heavy duty Euro5 EGR-engine sensitivity to fuel change with emphasis on combustion and emission formation

A diesel engine developed for an international market must be able to run on different fuels considering the diesel fuel qualities and the increasing selection of biofuels in the world. This leads to the question of how different fuels perform relative to a standard diesel fuel when not changing the hardware settings. In this study five fuels (Japanese diesel, MK3, EN590 with 10% RME, EN590 with 3

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As part of aiming towards a non-smoking hospital environment, staff at a Copenhagen university hospital were offered participation in a differentiated smoking cessation programme. This consisted of lectures, group therapy, follow-up visits and individually tailored nicotine replacement therapy free-of-charge for six weeks. Three hundred and seventy-four employees started the programme, with 353 co

The Trolley Problem and Isaac Asimov's First Law of Robotics

How to make robots safe for humans is intensely debated, within academia as well as in industry, media and on the political arena. Hardly any discussion of the subject fails to mention Isaac Asimov’s three laws of Robotics. We find it curious that a set of fictional laws can have such a strong impact on discussions about a real-world problem and we think this needs to be looked into.The probably mHow to make robots safe for humans is intensely debated, within academia as well as in industry, media and on the political arena. Hardly any discussion of the subject fails to mention Isaac Asimov’s three laws of Robotics. Asimov’s laws and the Trolley Problem are usually discussed separately but there is a connection in that the Trolley Problem poses a seemingly unsolvable problem for Asimov’s F

Cathodoluminescence investigations of dark-line defects in platelet-based InGaN nano-LED structures

We have investigated the optical properties of heterostructured InGaN platelets aiming at red emission, intended for use as nano-scaled light-emitting diodes. The focus is on the presence of non-radiative emission in the form of dark line defects. We have performed the study using hyperspectral cathodoluminescence imaging. The platelets were grown on a template consisting of InGaN pyramids, flatte

Creative Work and Mental Health

This chapter identifies factors impacting artists’ and cultural workers’ mental health. Structural conditions constitute power imbalances, such as inclusion mechanisms that influence privilege and possibilities to exhibit/publish artwork. Structural conditions also have an impact on the distribution of financial resources and the forming of new collective and inclusive networks, creating alternati

Safety of continuing mineralocorticoid receptor antagonist treatment in patients with heart failure with reduced ejection fraction and severe kidney disease : data from Swedish Heart Failure Registry

Aims: Mineralocorticoid receptor antagonists (MRAs) improve outcomes in heart failure with reduced ejection fraction (HFrEF) but remain underused and are often discontinued especially in patients with chronic kidney disease (CKD) due to concerns on renal safety. Therefore, in a real-world HFrEF population we investigated the safety of MRA use, in terms of risk of renal events, any mortality and an

Oat Kilning and Its Effects on Liquid Oat-Base Production

The aim of this study was to give insights on the effects of an industrially relevant kilning method, with a focus on lipase inactivation and oat-base production. Storage of non-kilned, dehulled oat kernels in either room temperature or at 37 °C for up to 64 days led to increasing lipase activity with time, despite a decrease in moisture content and water activity, demonstrating the importance of

Phenolic compounds from Syzygium jambos (Myrtaceae) exhibit distinct antioxidant and hepatoprotective activities in vivo

HPLC-PDA-MS/MS analysis of Syzygium jambos leaf extract allowed the identification of 17 secondary metabolites, including flavonol glycosides, flavonol di-glycosides, and flavones as well as ellagitannins and phenolic acids. The extract showed promising antioxidant activities in different experimental models. In Caenorhabditis elegans, the extract mediated a dose dependent survival rate and decrea

Detection of mitochondrial single nucleotide polymorphisms using a primer elongation reaction on oligonucleotide microarrays

We have developed a novel allele-specific primer elongation protocol using a DNA polymerase on oligonucleotide chips. Oligonucleotide primers carrying polymorphic sites at their free 3'end were covalently bound to glass slides. The generation of single-stranded targets of genomic DNA containing single nuclotide polymorphisms (SNPs) to be typed was achieved by an asymmetric PCR reaction or exonucle

Sufficiency, change, and flexibility : Critically examining the energy consumption profiles of solar PV prosumers in Sweden

The number of consumers producing electricity at home, i.e., “prosumers”, is rapidly increasing in many European countries. This article analyses the electricity consumption and energy-saving behaviours of households that own photovoltaic (PV) systems in Sweden. Earlier studies of how home production of electricity affects consumption patterns are few and their results are mixed. We interviewed pr

Synthesis and polymerization of isosorbide-based monomethacrylates

Isosorbide-5-methacrylate was obtained by enzymatic catalysis with Lipozyme RM IM in a highly regioselective manner in up to 87% yield. The process uses readily available acyl donors (methacrylic anydride or vinyl methacrylate), is easily scalable and chromatography free. Simple extractive workup followed by decoloration and filtration affords the monomer with up to > 99% purity. In addition, the

Creating and detecting poor man's Majorana bound states in interacting quantum dots

We propose and theoretically investigate an alternative way to create the poor man's Majorana bound states (MBSs) introduced in Phys. Rev. B 86, 134528 (2012)10.1103/PhysRevB.86.134528. Our proposal is based on two quantum dots (QDs) with strong electron-electron interactions that couple via a central QD with proximity-induced superconductivity. In the presence of spin-orbit coupling and a magneti

The two-domain elevator-type mechanism of zinc-transporting ZIP proteins

Zinc is essential for all organisms and yet detrimental at elevated levels. Hence, homeostasis of this metal is tightly regulated. The Zrt/Irt-like proteins (ZIPs) represent the only zinc importers in metazoans. Mutations in human ZIPs cause serious disorders, but the mechanism by which ZIPs transfer zinc remains elusive. Hitherto, structural information is only available for a model member, BbZIP

Translanguaging in EFL with students transitioning to secondary school : Towards a best practice

In secondary-school English-as-a-foreign-language (EFL) classrooms worldwide, English tends to be used alongside the society or community majority language (Brevik & Rindal 2020; Tsagari & Diakou 2015; Üstünel 2016), and research reveals greater participation and positive attitudes among students when translanguaging is permitted (Ebe 2016; Kleyn 2016; Saxena 2009; Ollerhead 2019; Seltzer

Taking snapshots of photosynthetic water oxidation using femtosecond X-ray diffraction and spectroscopy.

The dioxygen we breathe is formed by light-induced oxidation of water in photosystem II. O2 formation takes place at a catalytic manganese cluster within milliseconds after the photosystem II reaction centre is excited by three single-turnover flashes. Here we present combined X-ray emission spectra and diffraction data of 2-flash (2F) and 3-flash (3F) photosystem II samples, and of a transient 3F

Design and Evaluation of nonuniform DFT filter banks in Subband Microphone Arrays

This paper presents a method for the design of nonuniform DFT filter banks for subband beamforming. Filter banks designed with the method are evaluated in subband beamforming in a real-world microphone array application. Different source positions in array applications give rise to different signal delays, which means that adaptive beamformers in the subbands alter the phase information of the sub