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The core protein of proteoglycans from cartilage is substituted with glycosaminoglycans as well as N- and O-glycosidically linked oligosaccharides. We have taken advantage of the long intracellular half-life of the core protein precursor to the rat chondrosarcma proteoglycan to study the temporal relationship between the addition of the chondroitin sulfate chains and the O-linked oligosaccharides

Purpose: Glucose concentrations are elevated in retinal cells in undiagnosed and in undertreated diabetes. Studies of diabetic patients suggest that retinal function adapts, to some extent, to this increased supply of glucose. The aim of the present study was to examine such adaptation in a model of type 2 diabetes and assess how the retina responds to the subsequent institution of glycemic contro

Nearly all mammalian cells express a set of genes known as clock genes. These regulate the circadian rhythm of cellular processes by means of negative and positive autoregulatory feedback loops of transcription and translation. Recent genomewide association studies have demonstrated an association between a polymorphism near the circadian clock gene CRY2 and elevated fasting glucose. To determine

Accurate and precise chronologies are needed to evaluate the existence and effect of a post-depositional remanent magnetization lock-in process on sedimentary palaeomagnetic records. Here we present lock-in modelling results of two palaeomagnetic records from varved lake sediments (lakes Kalksjon and Gyltigesjon) in Sweden by using model predictions based on archaeomagnetic data. We used the C-14

Qualitative measurements of both OH and polycyclic aromatic hydrocarbons (PAH) as well as quantitative data of soot volume fraction f(v) have been obtained in vaporized liquid fuels, with the main goal of providing experimental data for combustion models and numerical mechanism validation. Measurements were carried out in a laminar coflow burner which was designed, built and integrated with an eva

All notified MRSA cases in SkAyenne County have been followed since 2000. We have investigated the MRSA epidemiology over time, method of acquisition, whether some spa types are more prone to spread, and/or cause more infections, and the connection between spa type and country of acquisition/origin. All cases between 2000 and 2010 were included. Infection or colonization and the presence of PVL ge

An unbalanced chromosome number (aneuploidy) is present in most malignant tumours and has been attributed to mitotic mis-segregation of chromosomes. However, recent studies have shown a relatively high rate of chromosomal mis-segregation also in non-neoplastic human cells, while the frequency of aneuploid cells remains low throughout life in most normal tissues. This implies that newly formed aneu

Dug trenches in sediment-cored drumlins on the Småland peneplain, southern Sweden, occurring intermixed with rock-cored drumlins, revealed sedimentary successions and facies suggesting that the core sediments were primarily deposited proglacially, both in glaciolacustrine settings as delta-front and more distal deeper-water sediments, and as glaciofluvial braidplain sediments. From the relationshi

Background: The aim of this study was to determine whether relative qualitative and quantitative differences in protein expression could be related to smoke exposure or smoke-induced airway inflammation. We therefore explored and characterized the protein components found in bronchoalveolar lavage (BAL) fluid sampled from either lifelong smokers or never-smokers. Methods: BAL fluid samples obtaine

This study investigates strategies for igniting hydrogen in compression ignition engines, a process traditionally hindered by hydrogen’s high ignition temperature. In conventional dual-fuel engines, a small diesel pilot is often used to ignite hydrogen, taking advantage of diesel’s lower ignition temperature to initiate combustion. While effective, this approach introduces carbon emissions, limiti

Background: Early cardiopulmonary resuscitation (CPR) and defibrillation with an Automated External Defibrillator (AED) increase survival from out-of-hospital cardiac arrest (OHCA). Although international guidelines recommend the use of AED registries to increase AED use, little is known about implementation. The aim of this paper is to describe the development of a national AED registry, to analy

Popular Abstract in Swedish Populärvetenskaplig sammanfattning Introduktion Adrenokortikotropiskt hormon (ACTH) stimulerar frisättningen av steroid¬hormoner, främst kortisol, från binjurarna. Kortisol är livsnödvändigt och finns alltid i blodet och förhöjs kraftigt vid stress. I början av 90-talet fann vår forskningsgrupp en koppling mellan ACTH och fettomsättningen som inte involverade steroidhAbstract Adrenocorticotrophic hormone (ACTH) has strong and direct lipid-lowering effects in man. All apoB-containing lipoproteins, i.e. VLDL, LDL, Lp(a), are reduced by 25-30%. In contrast, levels of HDL increase about 10%. In hepatic cell cultures, ACTH inhibits expression and secretion of apoB. In this thesis we corroborate that the reduced apoB synthesis, seen in hepatic cell systems, is als

Within the framework of the European Land Arctic Physical Processes project and as part of the Danish Research Council's Polar Program, a study on trace gas exchange in a high-arctic ecosystem was conducted in NE Greenland, May-August 1997. On the basis of carbon dioxide flux measurements from three dominant surface types, this paper reports on the upscaling of such measurements from canopy to lan

Background and Objectives The aim of this study was to evaluate the pharmacokinetics, efficacy and safety of a newly developed 10% liquid immunoglobulin preparation in patients with primary immunodeficiency diseases. This new preparation for intravenous use includes three dedicated virus clearance steps in its manufacturing process to ensure a high margin of viral safety. Materials and Methods Thi

How do donors reason and justify their choices when faced with dilemmas in a charitable context? In two studies, Swedish students were confronted with helping dilemmas based on the identifiable victim effect, the proportion dominance effect and the ingroup effect. Each dilemma consisted of two comparable charity projects and participants were asked to choose one project over the other. They were t

We compare abundance ratio trends in a sample of ∼11,000 Milky Way bulge stars (R GC < 3 kpc) from the Apache Point Observatory Galactic Evolution Experiment (APOGEE) to those of APOGEE stars in the Galactic disk (5 kpc < R GC < 11 kpc). We divide each sample into low-Ia (high-[Mg/Fe]) and high-Ia (low-[Mg/Fe]) populations, and in each population, we examine the median trends of [X/Mg] versus [Mg/

The ontogenetic development of size heterogeneity and aggression was monitored in commercial culture tanks of yellowtail kingfish (Seriola lalandi Valenciennes). Size heterogeneity increased substantially with the introduction of Artemia as a food source at 12 days post-hatch (DPH), and was correlated with the appearance of aiming behaviour, a precursor to more direct aggressive interactions. Chas

Context.Gaia Data Release 3 (DR3) contains the first release of magnitudes estimated from the integration of Radial Velocity Spectrometer (RVS) spectra for a sample of about 32.2 million stars brighter than GRVS∼ 14 mag (or G ∼ 15 mag). Aims. In this paper, we describe the data used and the approach adopted to derive and validate the GRVS magnitudes published in DR3. We also provide estimates of t

Nonradical-based advanced oxidation processes (AOPs) catalyzed by defective carbonaceous materials have exhibited great superiorities in trace antibiotics removal from natural water matrices. However, the complicated, extensive and highly-energy consumed synthesis methods are seriously hindering its development and application. Herein an in-situ electrochemical synthesis technology was developed a