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Approach to combine electron-beam lithography and two-photon polymerization for enhanced nano-channels in network-based biocomputation devices

Although conventional computer technology made a huge leap forward in the past decade, a vast number of computational problems remain inaccessible due to their inherently complex nature. One solution to deal with this computational complexity is to highly parallelize computations and to explore new technologies beyond semiconductor computers. Here, we report on initial results leading to a device

Managing conflicting desires in a garden plant; the case of the variegated daylily

A gardener in Småland, southeastern Sweden, tells that her father cultivated a double daylily, Hemerocallis fulva, with variegated leaves in Stockholm in the mid 20th century. When she moved to Småland, 45 years ago, she brought a piece of his plant with her, and later on she has spread the plant to others. This daylily, known as "Kwanso Variegata", was first found in Japan in 1776, and since then

Serious Game iDO: Towards Better Education in Dementia Care

We describe the iDO serious game developed during implementation of the Innovative Digital Training Opportunities on Dementia for Direct Care Workers (IDO) project. The project targets formal and informal caregivers of persons with dementia in order to improve caregiver knowledge and competences skills with a non-traditional source of training. This paper describes the steps faced to define the iD

Wing morphology of the butterfly Coenonympha arcania in Europe : Traces of both historical isolation in glacial refugia and current adaptation

In this study, we examined the evolutionary outcome of and interplay between historic isolation and current selection pressures on traits more or less closely connected to fitness in the Pearly Heath butterfly (Coenonympha arcania) across its range in Europe. We hypothesized that a trait mean is more related to historic events if it has low connection to fitness, while a trait more closely connect

The third sector of R&D : literature review, basic analysis, and research agenda

The third sector of national innovation systems comprises non-academic, publicly owned R&D organizations that complement universities and private-sector firms and are normally called ‘research institutes’. Scholarly attention to these organizations has been scarce, partly a consequence of the theoretical imbalance in favor of conceptualizations of innovation processes as requiring mainly unive

Landscaping the cell surface proteome of breast cancer : Following pathways through organelles to the plasma membrane

Breast cancer is one of the most common cancers in women. It is most commonly treated by the surgical removal of the tumour in combination with (neo)-adjuvant therapy (hormone, chemo- or radio- therapy before or after surgery). However, a large number of patients are over treated, with approximately 60% being given adjuvant therapy when already cured by surgery alone. This causes many undesirable

Impact of diesel pilot distribution on the ignition process of a dual fuel medium speed marine engine

Recent emission legislation in the marine sector has emphasized the need to reduce nitrogen oxides (NOx) emissions as well as sulphur emissions. The fulfilment of emission legislation limits with conventional marine diesel oil (MDO) requires complex and expensive aftertreatment systems and in this framework lean burn pilot ignited dual fuel (diesel and natural gas) is revealed as one of the most s

Mellan det förflutna och framtiden : Den sandinistiska revolutionen i Nicaragua

The theme throughout this book is the buildning up of a new societal structure and the conflicts encompassed in such a project. I discuss the societal changes in Sandinista Nicaragua by way of placing the revolution in a historic, political, and social context. Throughout the work process it became increasingly clear that the conflicts of the FSLN were in principal due to two factors. First, the F

Knowledge Representation for Learning How to Evaluate Partial Plans

In this paper we present some ideas for knowledge representation formalism suitable for rational agents which learn how to choose the best conditional, partial plan in any given situation. In our architecture, the agent uses an incomplete symbolic inference engine, employing Active Logic, to reason about consequences of performing actions — including information-providing ones. It utilises a simpl

Instrumentalized History and the Motif of Repetition in News Coverage of Japan-Taiwan Relations

Examining the coverage in seven major Japanese and Taiwanese daily newspapers of a selection of events involving both societies in the first decade of the twenty-first century, this paper investigates the phenomenon of rhetorical instrumentalization of the past for present ideological purposes. The concerns of this study are the processes of dehistorization in Japanese and Taiwanese news and publi

The impact of sub-cellular location and intracellular neuronal proteins on properties of GABA(A) receptors

Most studies of GABA(A) receptor accessory proteins have focused on trafficking, clustering and phosphorylation state of the channel-forming subunits and as a result a number of proteins and mechanisms have been identified that can influence the GABA(A) channel expression and function in the cell plasma membrane. In the light of a growing list of intracellular and transmembrane neuronal proteins s

Biosynthesis, Processing, and Sorting of Human Neutrophil Granule Proteins. Focus on Cathepsin G, Proteinase 3, and Azurocidin

Popular Abstract in Swedish Bildning, bearbetning och upplagring av cathepsin G, proteinas 3 och azurocidin - närbesläktade bakteriedödande proteiner i vita blodkroppar Människans kropp utsätts dagligen för fientliga attacker av olika sorters mikroorganismer, tillhörande bakterie-, virus- eller svampsläktet. Så länge vi är friska och vårt immunförsvar fungerar, kan vi som tur är framgångsrikt fö

Animal navigation : a noisy magnetic sense?

Diverse organisms use Earth's magnetic field as a cue in orientation and navigation. Nevertheless, eliciting magnetic orientation responses reliably, either in laboratory or natural settings, is often difficult. Many species appear to preferentially exploit non-magnetic cues if they are available, suggesting that the magnetic sense often serves as a redundant or 'backup' source of information. Thi

Dual origin of pairing in nuclei

The pairing correlations of the nucleus 120Sn are calculated by solving the Nambu–Gor’kov equations, including medium polarization effects resulting from the interweaving of quasiparticles, spin and density vibrations, taking into account, within the framework of nuclear field theory (NFT), processes leading to self-energy and vertex corrections and to the induced pairing interaction. From these r

Concentration-and pH-dependent oligomerization of the thrombin-derived C-terminal peptide TCP-25

Peptide oligomerization dynamics affects peptide structure, activity, and pharmacodynamic properties. The thrombin C-terminal peptide, TCP-25 (GKYGFYTHVFRLKKWIQKVIDQFGE), is currently in preclinical development for improved wound healing and infection prevention. It exhibits turbidity when formulated at pH 7.4, particularly at concentrations of 0.3 mM or more. We used biochemical and biophysical a

Understanding the spreadsheets use in budgeting

This paper explores the use of spreadsheets in budgeting in order to explain how and why spreadsheets are used or not used in budgeting practice. Guided by modern budgeting research, budgeting is considered as a social phenomenon which requires flexibility for decision-making and integration for management control. Twenty-one interviews with business controllers in eleven leading for-profit organi

Research Library Statistics: For Whom and for What Purpose? The Statistics Users' Views and Wishes

The paper reports a project conducted within the framework of the National Library of Sweden's Expert Group on Library Statistics. The project is financed by the National Library of Sweden, and it aims to capture how library managements make use of the current library statistics (based on the ISO-standard) in the decision-making process. Questions are also asked about the quality and usefulness of

Traumatic Peripheral Nerve Injuries : Experimental Models for Repair and Reconstruction

Peripheral nerve injuries are difficult to treat, and the clinical outcome after surgical repair and reconstruction is still insufficient, particularly concerning recovery of sensory function. To improve the clinical treatment strategies, experimental models are used to systematically examine the mechanisms behind nerve regeneration and assess the improvement of nerve regeneration by introduction

Early and advanced stages of Maillard reaction in infant formulas : Analysis of available lysine and carboxymethyl-lysine

Although the literature on the Maillard reaction in infant formulas is extensive, most studies have focused on model systems, and in only a few cases on real food systems. Therefore, the objective of the present study was to determine the status of the Maillard reaction, both the early and advanced phases, in a variety of commercial infant formulas available on the Swedish market. Ten powder and l