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Avsikten med detta projekt har varit att utveckla väl fungerande rutiner för PIXE-analys av biologiska prov med anknytning till exponering i arbetsmiljösituationer. Kravet på metoderna är att de tillvaratar PIXE-metodens fördelar (multielementanalys, små prov, snabb analys, låga detektionsgränser) och samtidigt förändrar eller förstör så lite som möjligt av den information som finns i de ursprungl
DNA methylation patterns change with age and can be used to derive an estimate of "epigenetic age," an indicator of biological age. Several studies have shown associations of posttraumatic stress disorder (PTSD) with worse somatic health and early mortality, raising the possibility of accelerated biological aging. This study examined associations between estimated epigenetic age and various variab
BACKGROUND: An increasing number of women are evaluated for potential breast cancer and may experience mental distress during evaluation. We aim to assess the risks of psychiatric disorders and cardiovascular diseases during the diagnostic workup of potential breast cancer.METHODS: All women with a new diagnosis of unspecified lump in breast (N = 15,714), benign tumor or breast cancer in situ (N =
Background: Little attention has been given to the risk of cardiovascular and psychiatric comorbidities during the clinical evaluation of a suspected hematological malignancy.Methods: Based on Skåne Healthcare Register, we performed a population-based cohort study of 1,527,449 individuals residing during 2005-2014 in Skåne, Sweden. We calculated the incidence rate ratios (IRRs) of cardiovascular d
Anthropogenic land-cover change (ALCC) is one of the few climate forcings for which the net direction of the climate response over the last two centuries is still not known. The uncertainty is due to the often counteracting temperature responses to the many biogeophysical effects and to the biogeochemical versus biogeophysical effects. Palaeoecological studies show that the major transformation of
The aim of this report is to establish recommendations for reviewing, reporting, and conducting research during the post-resuscitation period in hospital. It defines data that are needed for research and more specialised registries and therefore supplements the recently updated Utstein template for resuscitation registries. The updated Utstein template and the out-of-hospital "Chain of Survival" d
Chronotypes describe consistent differences between individuals in biological time-keeping. They have been linked both with underlying variation in the circadian system and fitness. Quantification of chronotypes is usually by time of onset, midpoint, or offset of a rhythmic behaviour or physiological process. However, diel activity patterns respond flexibly to many short-term environmental influen
Urbana översvämningar orsakar stora samhällsskador och skyfallens snabba och lokala karaktär gör dem svåra att observera, förutsäga och varna för. Det finns också brist på data om översvämningsskador, främst på grund av knapp och icke-systematisk datainsamling och -hantering. I denna artikel presenterar vi ett nytt forskningsprojekt: SPARC. Det övergripande syftet med projektet är att förbättra säUrban flooding causes large societal damages and increased climate adaptation measures is needed. Therapid and local character of extreme rain events make them difficult to observe and predict, and to issuewarnings for. There is also a lack of data on urban flood damages, mainly because of scarce and nonsystematic data collection and management. In this paper, we present the approaches behind the
Background: A substantial proportion of women with breast cancer (BC) experience a wide range of long-term persistent and troublesome side effects related to the disease and its treatment. The ReScreen randomized controlled trial is conducted aiming to evaluate the effect of early screening of distress followed by individualized rehabilitation after primary BC treatment.Purpose: To examine recruit
Aquaporin-4 (AQP4) is the predominant water channel in the brain; it is enriched in astrocytic foot processes abutting vessels where it is anchored through an interaction with the dystrophin-associated protein (DAP) complex. Enhanced expression with concomitant mislocalization of AQP4 along astrocyte plasma membranes is a hallmark of several neurological conditions. Thus, there is an urgent need t
Spatial transcriptomics (ST) maps RNA level patterns within a tissue. This technology has not been previously applied to human placental tissue. We demonstrate analysis of human placental samples with ST. Unsupervised clustering revealed that distinct RNA patterns were found corresponding to different morphological structures. Additionally, when focusing upon terminal villi and hemoglobin associat
Abstract: Birds have evolved morphological, physiological and behavioural adaptations, encoded in their migratory programs, to enable successful migration. Sometimes, even closely related species, such as the Eurasian reed warbler and the sedge warbler, may adopt different migration strategies to reach their wintering grounds in sub-Saharan Africa. To study them in detail, we aimed to compare the
Wintering energy management in small passerines has focused on the adaptive regulation of the daily acquisition of energy reserves within a starvation-predation trade-off framework. However, the possibility that the energetic cost of living, i.e. basal metabolic rate (BMR), is being modulated as part of the management energy strategy has been largely neglected. Here, we addressed this possibility
The transcription factor ZNF224 plays a key proapoptotic role in chronic myelogenous leukemia (CML), by modulating Wilms Tumor protein 1 (WT1) dependent apoptotic genes transcription. Recently, we demonstrated that Bcr-Abl signaling represses ZNF224 expression in Bcr-Abl positive CML cell lines and in CML patients. Interestingly, Imatinib and second-generation tyrosine kinase inhibitors specifical
The contribution of the understorey vegetation to the spectral reflectance from the top of a forest canopy was investigated by the use of a forest canopy reflectance model. Detailed field data, i.e. forest leaf area index (LAI), tree structural parameters like the height, diameter and crown length of the trees, and the composition, distribution and reflectance of the forest floor, was collected fo
This paper is part of my ongoing doctoral research centered on “Street Art and Cognitive Semiotics: The case of Athens” at the division of Cognitive Semiotics at Lund University. More concretely, in this article, a fresh approach, based on a constructive (verbo-) pictorial argument, is taken to attending the relationship between a cognitive semiotics approach and street art signs in a programmatic
This chapter unpacks the complex and contested nature of ‘irregular labour migration’ and explores the meaning and analytical rigour of this conceptualisation. We discuss four social positions: 1) authorised migrant regular worker, 2) authorised migrant irregular worker, 3) unauthorised migrant irregular worker and 4) unauthorised migrant regular worker. Using the distinctions between informalisat
