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The need for large-scale production of highly accurate simulated event samples for the extensive physics programme of the ATLAS experiment at the Large Hadron Collider motivates the development of new simulation techniques. Building on the recent success of deep learning algorithms, variational autoencoders and generative adversarial networks are investigated for modelling the response of the cent
Denna kunskapsöversikt sammanfattar effekterna av olika boendeinsatser för att motverka hemlöshet. Kunskapsöversikten har tagits fram genom en överenskommelse med Socialstyrelsen. Översikten är en uppdatering av rapporten Boendelösningar för hemlösa personer – en kunskapsöversikt, som Socialstyrelsen publicerade 2009. Underlaget består av 96 vetenskapligt granskade studier publicerade efter 2009,
Urbanisation is proceeding at an alarming rate which forces wildlife to either retreat from urban areas or cope with novel stressors linked to human presence and activities. For example, urban stressors like anthropogenic noise, artificial light at night and chemical pollution can have severe impacts on the physiology of wildlife (and humans), in particular the immune system and antioxidant defenc
The paper investigates the potential for a packet switching network for real-time image processing by a Cellular Neural Network (CNN) implemented on a Field-Programmable Gate-Array (FPGA). The implementation of a CNN requires several parameter restrictions with respect to the universal concept. For instance, the number representation and the cloning template are often confined to respectively 8 bi
Popular Abstract in Swedish Övervikt är ett av vår tids största hälsoproblem, kanske till och med det största. Det finns de som menar att redan idag utgör övervikt globalt sett en viktigare orsak till sjukdom än undernäring och infektionssjukdomar. Framtidsscenariot beskrivs som alarmerande. Folk kommer att i en tidigare aldrig skådad omfattning insjukna i överviktens följdsjukdomar. Medierna harThe prevalence of overweight and obesity is rising each year not only on a national but also on a global level. The future scenario is troublesome. The media are among the most important social institutions in influencing people’s knowledge, perceptions and actions. The media provide citizens with health messages and contribute thereby to their health development. This dissertation deals with two
Background Mental health interventions should demonstrate an effect on patients' functioning as well as his/her needs, in particular on unmet needs whose assessment depends on the perspective of either the patient or the clinician. However, individual met and unmet needs appear to change over time, qualitatively and quantitatively, raising questions about their sensitivity to change and about the
Insulin secretion is controlled by the beta cell's metabolic state, and the ability of the secretory granules to undergo exocytosis increases during glucose stimulation in a membrane potential-independent fashion. Here, we demonstrate that exocytosis of insulin-containing secretory granules depends on phosphatidylinositol 4-kinase (PI 4-kinase) activity and that inhibition of this enzyme suppresse
BACKGROUND: Proliferative markers are not recommended as prognostic factors for clinical use in breast cancer due to lack of standardization in methodology. However, proliferation is driving several gene expression signatures emphasizing the need for a reliable proliferative marker for clinical use. Studies suggest that cyclin A is a prognostic marker with satisfying reproducibility. We investigat
A common mammalian defense mechanism employed to prevent systemic dissemination of invasive bacteria involves occlusion of local microvasculature and encapsulation of bacteria within fibrin networks. Acquisition of plasmin activity at the bacterial cell surface circumvents this defense mechanism, allowing invasive disease initiation. To facilitate this process, S. pyogenes secretes streptokinase,
Med en enkätstudie undersöks i detta projekt hur effektivt de berörda anser att de medieetiska systemen ger upprättelse. Här är det värt att nämna att vi då arbetet inleddes bad PO-kansliet om hjälp att distribuera vår enkät till alla dem som stod bakom framgångsrika anmälningar under 2015. På så sätt skulle enkäten kunna genomföras samtidigt som anonymiteten i PO-systemet kunde
From the point of view of each individual’s sense-making, an organization is an emergent property of inter-individual sense-making processes and activities. The organization is a result of emergence from individual sense-making perspectives. A critically informed approach to research involves recognition / understanding of this emergence. Without the recognition of the uniqueness of each particula
Popular Abstract in Swedish Proteinkinas C (PKC) är en familj enzymer (protein som påskyndar cellulära förlopp) bestående av åtminstone 10 medlemmar (isoformer) vilka är involverade i ett flertal cellulära processer. Varje isoform är namngiven med en grekisk bokstav och beroende på olika egenskaper hos enzymerna kan PKC familjen delas in i tre undergrupper, de klassiska (α, βΙ, βΙΙ och γ), de nya Protein kinase C (PKC) is a family of serine/threonine kinases subgrouped into classical (α, βI, βII, γ), novel (δ, ε, η, θ) and atypical (ζ, ι/λ) isoforms. PKC can be activated by phorbol esters, and prolonged treatment of neuroblastoma cells has been shown to induce neuronal differentiation with neurite outgrowth and increased expression of neuronal genes. Here we show that a classical PKCβ isof
In the course of his life’s work, Claudio Ciborra addressed many interesting and complex problem areas of information systems, from management of corporate information infrastructures to organizational learning. However, a unifying theme which permeated his work was an emphasis on recognizing ‘users’ as real human beings, not idealised types. He considered people, leading real, every-day lives; no
Dynamic glucose-enhanced (DGE) imaging uses chemical exchange saturation transfer magnetic resonance imaging to retrieve information about the microcirculation using infusion of a natural sugar (D-glucose). However, this new approach is not yet well understood with respect to the dynamic tissue response. DGE time curves for arteries, normal brain tissue, and cerebrospinal fluid (CSF) were analyzed
Aim: Target temperature management (TTM) at 32-36 °C is recommended in unconscious survivors of cardiac arrest. This study reports awakening in the TTM-trial. Our predefined hypotheses were that time until awakening correlates with long-term neurological outcome and is not affected by level of TTM. Methods: Post-hoc analysis of time until awakening after cardiac arrest, its association with long-t
Popular Abstract in Swedish Cancer är ett samlingsnamn för en grupp av sjukdomar som karakteriseras av att cellerna delar sig okontrollerat, till skillnad mot kroppens friska celler. Det leder till att en tumör kan bildas och cellerna kan därifrån sprida sig till andra delar av kroppen och ge upphov till dottertumörer, även kallade metastaser. I Sverige uppskattar man att cirka var tredje person kSmall cell lung carcinoma (SCLC) is a very aggressive solid tumor and is often widely metastasized by the time of diagnosis. Despite good response to the initial chemotherapy, SCLC cells often develop multidrug resistance to conventionally used chemotherapeutic drugs, which cause almost all SCLC tumors to relapse. The 5-year survival rate for patients with limited disease is around 20% while it is
Background As a part of the Service Organization’s earlier initiated and at the moment on-going project; “A more efficient Service Organization”, daily management has been identified as playing a major part. The starting-point for this has been to gain insight into how the Service Organization is actually performing and how it would be possible to measure, follow-up and visualize this performance.
Detta examensarbete rör direktiv 2006/46/EG och dess överensstämmelse med den europeiska konventionen om skydd för de mänskliga rättigheterna och de grundläggande friheterna. Examensarbetet använder Sverige som ett exempel, och analyserar främst lagen (2003:389) om elektronisk kommunikation och dess tillkortakommanden vad gäller brottsbekämpande myndigheters tillgång till lagrade trafikuppgifter. This thesis concerns Directive 2006/46/EC and its compliance with the European Convention on Human Rights and Fundamental Freedoms. The thesis uses Sweden as an example, and mainly analyses the shortcomings in Swedish legislation on how traffic data may be accessed by law enforcement authorities, finding that the regulations under the Swedish Electronic Communications Act breaches Article 8 and 13
