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IMPORTANCE: Discontinuation and nonpublication are established sources of avoidable waste among surgical trials, but rates of delayed completion and recruiting shortfalls remain unclear.OBJECTIVES: To examine the rate of delayed completion, incomplete enrollment, and discontinuation among randomized clinical trials in surgical populations and the duration of delays and extent of recruiting shortfa

BACKGROUND: Most cerebral palsy (CP) cases have an unexplained etiology, but a role for environmental exposures has been suggested. One purported environmental risk factor is exposure to endocrine-disrupting pollutants specifically per- and polyfluoroalkyl substances (PFAS).OBJECTIVES: We investigated the association between prenatal PFAS exposures and CP in Swedish children.METHODS: In this case-

BACKGROUND: Although most pediatric radial neck fractures can be treated with either immobilization alone or closed reduction and immobilization, a small subset result in permanent loss of motion despite surgical management. We sought to characterize the most problematic fractures and correlate final outcomes with both presenting fracture characteristics and the reduction achieved through surgical

Background: Despite newer treatments with immunosuppressive agents, there still exists a considerable morbidity and mortality risk among patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Since 1994 the European Vasculitis Society (EUVAS) has aimed for an improved outcome for patients with AAV, conducting several prospective randomized controlled trials (RCTs).

BACKGROUND: Oncological outcome after radical radiotherapy (RRT) combined with neoadjuvant and adjuvant androgen suppression therapy (AST) may differ according to type of AST. The aim of this nationwide register-based study was to investigate risk of prostate cancer (Pca) death after different neoadjuvant and adjuvant ASTs; (i) bicalutamide, (ii) gonadotropin-releasing hormone agonists (GnRH) or (

BackgroundCorrect ABO blood-group matching between donor and patient is crucial for safe transfusions. We investigated the underlying reason causing inconclusive ABO serology in samples referred to our laboratory.Study Design and MethodsFlow cytometric analysis, ABO genotyping, and sequencing were used to characterize ABO-discrepant blood samples (n = 13). ABO gene variants were inserted in a GFP-

Over the last decades, the impact of human activities on the global nitrogen (N) cycle has drastically increased. Consequently, benthic N cycling has mainly been studied in anthropogenically impacted estuaries and coasts, while in oligotrophic systems its understanding is still scarce. Here we report on benthic solute fluxes and on rates of denitrification, anammox, and dissimilatory nitrate reduc

ims In atrial fibrillation (AF), a relation between electrocardiogram (ECG) fibrillatory wave amplitude and thrombus formation has been sought for long with conflicting results. In contrast, the possible relation between atrial fibrillatory rate obtained from the surface ECG and left atrial thrombus formation in patients with AF is unknown and was consequently evaluated in this study. Methods and

A REE-bearing fluorosilicate from the Tommot REE-Nb deposit in Yakutia, Russia, described without a name in 1966, is characterized here as a new species, proshchenkoite-(Y), of the vicanite group of borosilicates. Wavelength-dispersive electron probe analyses gave the following empirical formula: (Y3.70REE7.54Ca1.55Na1.16Mn0.77Th0.10Pb0.01)(Sigma 14.83)(Fe0.832+M0.15Ti0.02)(Sigma 1.00)Ca-1.00 (P0.

Fibromuscular dysplasia (FMD) mainly affects renal arteries. Percutaneous transluminal renal angioplasty (PTRA) and surgery are effective treatments, but longtime follow-up is lacking. Retrospective follow-up for 7.0 +/- 4.7 years of 69 consecutive patients ( age 44 +/- 13 years) treated for hypertension due to FMD, 59 patients underwent PTRA and eight patients surgery. In two patients no PTRA was

Background and aims. Adverse events (AE) leading to discontinuation or dose-reduction of thiopurine therapy (TP) occur in 9-28% of patients with inflammatory bowel disease. 6-Thioguanine (6-TG) has been proposed as an alternative treatment in patients intolerant for azathioprine (AZA), but some concerns have been raised about drug safety. Methods. We evaluated in a prospective manner the tolerance

Background The alpha-emitter radium-223 (Ra-223) is a bone-seeking radionuclide studied as a new treatment for patients with bone metastases from hormone-refractory prostate cancer. We aimed to study mature outcomes from a randomised, multicentre, phase II study of Ra-223. Methods Patients with hormone-refractory prostate cancer and bone pain needing external-beam radiotherapy were assigned to fou

A rheological study of mixed micelles formed by PEO-PPO-PEO triblock copolymer P123 and nonionic surfactant C12EO6 in aqueous solutions has been carried out with the purpose of investigating the time dependence of a shape transition of the mixed micelles and characterizing the shape before and after the transition. The rheology results presented in this report give clear evidence that the P123-C12

Microsoft Word - Utlysning teman 2016-2017.doc           Postadress: Pufendorfinstitutet, Lunds universitet, Box 117, SE-221 20 Lund. Besöksadress: Biskopsgatan 3, Lund www.pi.lu.se Pu fendor f ins t i tu te t Inbjudan att inkomma med förslag till "teman" vid Pufendorfinstitutet 2016 Pufendorfinstitutet inbjuder nu till att ansöka om "tema" med start hösten 2016. Institutets ambition är att, under

https://www.pi.lu.se/sites/pi.lu.se/files/utlysning_teman_2016-2017.pdf - 2026-05-23

2014 ANTIMICROBIAL RESISTANCE Global Report on Surveillance 2014 ANTIMICROBIAL RESISTANCE Global Report on Surveillance IV WHO Library Cataloguing-in-Publication Data Antimicrobial resistance: global report on surveillance. 1.Anti-infective agents - classification. 2.Anti-infective agents - adverse effects. 3.Drug resistance, microbial - drug effects. 4.Risk management. 5.Humans. I.World Health Or

https://www.sepsis.lu.se/sites/sepsis.lu.se/files/amr_who_report.pdf - 2026-05-23

Objectives: Pregnancy can influence immune control of Mycobacterium tuberculosis infection (MtbI). We recently reported an association between MtbI and pregnancy complications, particularly severe preeclampsia, in a registry-based cohort of women originating in tuberculosis-endemic countries screened for MtbI in Swedish antenatal care, implying a potential role of MtbI for the development of preec

BACKGROUND: Brief Admission by self-referral (BA) was implemented in 2018 in Swedish child and adolescent psychiatric (CAP) inpatient care. This intervention empowers adolescents to self-admit at their own request for brief periods to prevent self-harm and suicidal crisis. As BA enhances healthcare user autonomy, it is a timely intervention to consider with the emerging human rights discourse and

5-Hydroxymethylfurfural (HMF) is a versatile bio-based platform chemical that can substitute fossil-derived intermediates in polymers, solvents, and fuels, thereby contributing to a fossil-free chemical industry. While first-generation feedstocks such as high-fructose corn syrup have been widely studied, their use raises concerns about competition with food supply. In contrast, second-generation r

Background: The impact of air pollution and road traffic noise on depression remains inconclusive. This study examined long-term residential exposure to air pollutants and road traffic noise in relation to dispensed antidepressant medications. Methods: A cohort study was conducted using the Swedish Malmö Diet and Cancer Study, with the outcome defined as a first dispensed antidepressant (ATC: N06A

Introduction Asthma may increase the risk of comorbidities and systemic inflammation, but population data are scarce. This study aimed to compare comorbidities and systemic inflammation between those with and without current asthma and to identify characteristics linked to comorbidities and biomarkers. Methods In a cross-sectional analysis of 28 828 people aged 50–64 in the Swedish CArdioPulmonary