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Genetic and Epigenetic Characterisation of Breast Tumours

Popular Abstract in Swedish Bröstcancer är den vanligaste cancerformen bland kvinnor i Sverige. Ungefär var tionde kvinna beräknas drabbas av bröstcancer, och i Sverige insjuknar ungefär 7.000 kvinnor årligen. Glädjande nog har överlevnaden förbättrats och nästan 90% lever 5 år efter sin diagnos och cirka två tredjedelar kan anses botade. Trots detta dör cirka 1.500 kvinnor i sjukdomen i Sverige vBreast tumours harbour a large amount of genetic and epigenetic alterations, which are associated with e.g. tumour aggressiveness, prognosis, and response to therapy. The heterogeneity of breast tumours is reflected in the identification of at least five molecular subtypes named basal-like, luminal A, luminal B, HER2-enriched and normal-like, which are believed to originate from different cell typ

The interaction effect of Effortful Control and Neuroticism on Problem-solving Coping

The primary purpose of this study was to establish an interaction effect between effortful control and neuroticism on problem‐solving coping. The secondary purpose was to examine the relationships between all three variables by establishing a correlation matrix. The sample consisted of 64 individuals, 18‐25 years old. The scores on the variables neuroticism and effortful control were used to creat

Polycyclic aromatic hydrocarbon (PAH) accumulation in Quercus palustris and Pinus nigra in the urban landscape of Gothenburg, Sweden

Trees have the potential to improve urban air quality as leaves and needles capture air pollutants from the air, but further empirical data has been requested to quantify these effects. We measured the concentration of 32 polycyclic aromatic hydrocarbons (PAHs) in leaves of pin oak (Quercus palustris) and needles of black pine (Pinus nigra) in the City of Gothenburg, Sweden, during the summer of 2

Discipline and Punish at Camp : Citizenship and the Issue of Violence at a Swedish Boy Scout Camp

This article examines reports of physical punishment at the national Swedish Boy Scout camp Åvatyr in 1950. The Swedish newspapers Dagens Nyheter and Expressen described the events in terms of bullying and violence, while the Camp directors declared that the reports were merely exaggerated accounts of innocent pranks and practical jokes. This article draws information from newspaper articles, ScouThis article examines reports of physical punishment at the national Swedish Boy Scout camp Åvatyr in 1950. The Swedish newspapers Dagens Nyheter and Expressen described the events in terms of bullying and violence, while the camp directors declared that the reports were merely exaggerated accounts of innocent pranks and practical jokes. This article draws information from newspaper articles, Scou

Chemical composition of airborne particles inside and outside a Swedish residence assessed by real time aerosol mass spectrometry

A number of deleterious health effects have been identified from exposure to outdoor air-borne particulate matter. This issue is complicated by the fact that people are spending most of the time indoors, where particles of both indoor and outdoor origin are present. The aim of this work was to assess the differences in particle chemical composition inside and outside of the residence and gain bett

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To mark her 90th birthday on 24 January, MaerzMusik – Festival for Time Issues will devote a special programme to Éliane Radigue, highlighting the many facets of the composer’s work.

Salvage radiotherapy after radical prostatectomy : functional outcomes in the LAPPRO trial after 8-year follow-up

OBJECTIVE: Radical prostatectomy reduces mortality among patients with localized prostate cancer, however up to 35% of patients will experience biochemical recurrence, often treated with salvage radiotherapy. The objective of the study was to investigate long-term effects of salvage radiotherapy. METHODS: A prospective, controlled, non-randomized trial at 14 Swedish center's including 4,003 patien

False-positive recalls in the prospective Malmö Breast Tomosynthesis Screening Trial

Objectives: To evaluate the total number of false-positive recalls, including radiographic appearances and false-positive biopsies, in the Malmö Breast Tomosynthesis Screening Trial (MBTST). Methods: The prospective, population-based MBTST, with 14,848 participating women, was designed to compare one-view digital breast tomosynthesis (DBT) to two-view digital mammography (DM) in breast cancer scre

Treating trauma and substance use in adolescents

Up to 80% of adolescents have experienced trauma and one‐in‐seven suffer from post‐traumatic stress disorder (PTSD), a chronic, debilitating psychiatric disorder. For 50% of these adolescents, the course of their illness is further complicated by a co‐occurring substance use disorder, which often develops from repeated self‐medication of PTSD symptoms. Once established, both disorders serve to mai

Evaluation of an assessment change project, engaging academics and the role of SoTL.

This study follows on from a network-based assessment redesign project at a Canadian university, to investigate factors relating to academic engagement and sustained implementation. The project was designed with mini-grants, embedded support and a community of practice. Assessment facilitators worked in discipline clusters to achieve mutual goals for assessment reform targeted at authentic develop

Domain-adversarial neural network for improved generalization performance of gleason grade classification

When training a deep learning model, the dataset used is of great importance to make sure that the model learns relevant features of the data and that it will be able to generalize to new data. However, it is typically difficult to produce a dataset without some bias toward any specific feature. Deep learning models used in histopathology have a tendency to overfit to the stain appearance of the t

Decreased excretion of urine glycosaminoglycans as marker in renal amyloidosis

BACKGROUND: The diagnosis of renal amyloidosis is normally established by kidney biopsy. In order to advance the determination of the diagnosis and the initiation of the therapy, fast and cheap, non-invasive diagnostic techniques are required.METHODS: Urine excretion of glycosaminoglycans (GAG) was measured in 10 patients with AA amyloidosis and 5 patients with AL amyloidosis and compared to 25 co

Urine IgG2/IgG4-ratio indicates the significance of the charge selective properties of the glomerular capillary wall for the macromolecular transport in glomerular diseases

BACKGROUND: Alterations of the charge-selective properties of the glomerular capillary wall are important constituents of the pathogenesis of many glomerular diseases. Thus, differences in the degree of such changes could be of help in understanding the mechanisms governing the transport of macromolecules across the glomerular capillary wall.METHODS: The ratio between urine concentrations of neutr

"Han talte de om som en hjälte" : Performativ maskulinitet i tv-serierna S*M*A*S*H och Pistvakt

”Han talte de om som en hjälte” examines the use of parody and satire in the Swedish comedy series S*M*A*S*H (1990) and Pistvakt (1998–2000) as well as the feature film Pistvakt – En albinovästern från de vita vidderna (2005). By analyzing how the series illustrates performative masculinity from the definitions of Judith Butler in Gender Trouble (1990), conclusions on whether they destabilize norm“Han talte de om som en hjälte ”examines the use of parody and satire in the Swedish comedy series S*M*A*S*H (1990) and Pistvakt (1998–2000) as well as the feature film Pistvakt – En albinovästern från de vita vidderna (2005). By analyzing how the series illustrates performative masculinity from the definitions of Judith Butler in Gender Trouble (1990), conclusions on whether they destabilize norm

Increased prevalence of thyroid peroxidase antibodies (TPO-Ab) in women with glomerulonephritis

In a cross-sectional study adjusting for age, gender, and catchment area, the prevalence of thyroid antibodies was assessed in 51 consecutive subjects with biopsy-proven glomerulonephritis and in 112 control subjects admitted for extracorporeal shock-wave lithotripsy treatment for renal stones. Women with glomerulonephritis had both a significantly greater prevalence of thyroid peroxidase antibodi

The Consultant's Quest : Expansion Game for the Opera The Prophecies

How can ludic play frame and assist the participants' interactions in an immersive opera? The Consultant's Quest was developed as an artistic response to the idea and the challenge of integrating articulated game-playing as a both methodic and affective instrument in relation to operatic elements. Presented as a card-driven board game in connection to the operatic experience The Prophecies, The CoHow can ludic play frame and assist the participants' interactions in an immersive opera? The Consultant's Quest was developed as an artistic response to the idea and the challenge of integrating articulated game-playing as a both methodic and affective instrument in relation to operatic elements. Presented as a card-driven board game in connection to the operatic experience The Prophecies, The Co

Air Pollution and Urban Green Space : Evidence of Environmental Injustice in Adama, Ethiopia

While air pollution data in Ethiopia is limited, existing studies indicate high levels of both ambient and household air pollution; rapid urbanization also threatens the preservation of urban green spaces. In this study, environmental injustice, or the disproportionate burden of environmental exposures on persons of lower socioeconomic status (SES), was explored among women in Ethiopia using a mot